ID   C4VC03_VAIC1            Unreviewed;       232 AA.
AC   C4VC03;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   27-MAR-2024, entry version 51.
DE   RecName: Full=6-phosphofructokinase {ECO:0000256|ARBA:ARBA00012055};
DE            EC=2.7.1.11 {ECO:0000256|ARBA:ARBA00012055};
DE   Flags: Fragment;
GN   ORFNames=NCER_102427 {ECO:0000313|EMBL:EEQ81249.1};
OS   Vairimorpha ceranae (strain BRL01) (Microsporidian parasite) (Nosema
OS   ceranae).
OC   Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Nosematidae;
OC   Vairimorpha.
OX   NCBI_TaxID=578460 {ECO:0000313|Proteomes:UP000009082};
RN   [1] {ECO:0000313|Proteomes:UP000009082}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BRL01 {ECO:0000313|Proteomes:UP000009082};
RX   PubMed=19503607; DOI=10.1371/journal.ppat.1000466;
RA   Cornman R.S., Chen Y.P., Schatz M.C., Street C., Zhao Y., Desany B.,
RA   Egholm M., Hutchison S., Pettis J.S., Lipkin W.I., Evans J.D.;
RT   "Genomic analyses of the microsporidian Nosema ceranae, an emergent
RT   pathogen of honey bees.";
RL   PLoS Pathog. 5:E1000466-E1000466(2009).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-
CC         bisphosphate + H(+); Xref=Rhea:RHEA:16109, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:32966, ChEBI:CHEBI:57634,
CC         ChEBI:CHEBI:456216; EC=2.7.1.11;
CC         Evidence={ECO:0000256|ARBA:ARBA00000432};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC       phosphate and glycerone phosphate from D-glucose: step 3/4.
CC       {ECO:0000256|ARBA:ARBA00004679}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR   EMBL; ACOL01001376; EEQ81249.1; -; Genomic_DNA.
DR   RefSeq; XP_002994920.1; XM_002994874.1.
DR   AlphaFoldDB; C4VC03; -.
DR   STRING; 578460.C4VC03; -.
DR   KEGG; nce:NCER_102427; -.
DR   VEuPathDB; MicrosporidiaDB:NCER_102427; -.
DR   HOGENOM; CLU_1195179_0_0_1; -.
DR   InParanoid; C4VC03; -.
DR   OrthoDB; 374214at2759; -.
DR   UniPathway; UPA00109; UER00182.
DR   Proteomes; UP000009082; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0003872; F:6-phosphofructokinase activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006002; P:fructose 6-phosphate metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.50.450; -; 1.
DR   InterPro; IPR022953; ATP_PFK.
DR   InterPro; IPR000023; Phosphofructokinase_dom.
DR   InterPro; IPR035966; PKF_sf.
DR   PANTHER; PTHR13697:SF4; ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE; 1.
DR   PANTHER; PTHR13697; PHOSPHOFRUCTOKINASE; 1.
DR   Pfam; PF00365; PFK; 1.
DR   PRINTS; PR00476; PHFRCTKINASE.
DR   SUPFAM; SSF53784; Phosphofructokinase; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Glycolysis {ECO:0000256|ARBA:ARBA00023152};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009082};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          89..201
FT                   /note="Phosphofructokinase"
FT                   /evidence="ECO:0000259|Pfam:PF00365"
FT   NON_TER         232
FT                   /evidence="ECO:0000313|EMBL:EEQ81249.1"
SQ   SEQUENCE   232 AA;  25876 MW;  209151061CF41534 CRC64;
     MKDFIEEFTL TIDTKSNELG KLYEELGLDV VYDTHSIKVC SSSLARIISI NEGIHVHTLI
     SGSEDKVIYD TLGNKVIVTF LRSKSLISVG IITSGGDAPG MNSAIRAIVR ICLKSGGSVY
     GVYRGFDGLI NDYICKLGWD TETHNSNEGG TVLLSFRSKE FYKREGRKRA VFNLIKRGIN
     SLIVLGGDGS LKGALILKNE WRELFRELLE EGKLDFLKDN NKVNDKYIND KE
//