Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

C4VBI7

- SYEC_NOSCE

UniProt

C4VBI7 - SYEC_NOSCE

Protein

Probable glutamate--tRNA ligase, cytoplasmic

Gene

NCER_102160

Organism
Nosema ceranae (strain BRL01) (Microsporidian parasite)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 23 (01 Oct 2014)
      Sequence version 1 (28 Jul 2009)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei140 – 1401ATPBy similarity
    Binding sitei166 – 1661GlutamateBy similarity
    Binding sitei321 – 3211GlutamateBy similarity
    Binding sitei324 – 3241ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi359 – 3635ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. glutamate-tRNA ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. tRNA aminoacylation for protein translation Source: InterPro

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glutamate--tRNA ligase, cytoplasmic (EC:6.1.1.17)
    Alternative name(s):
    Glutamyl-tRNA synthetase
    Short name:
    GluRS
    Gene namesi
    ORF Names:NCER_102160
    OrganismiNosema ceranae (strain BRL01) (Microsporidian parasite)
    Taxonomic identifieri578460 [NCBI]
    Taxonomic lineageiEukaryotaFungiMicrosporidiaNosematidaeNosema
    ProteomesiUP000009082: Unassembled WGS sequence

    Organism-specific databases

    EuPathDBiMicrosporidiaDB:NCER_102160.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 614614Probable glutamate--tRNA ligase, cytoplasmicPRO_0000388393Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliC4VBI7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni130 – 1323Glutamate bindingBy similarity
    Regioni303 – 3075Glutamate bindingBy similarity

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi135 – 14410"HIGH" regionBy similarity
    Motifi359 – 3635"KMSKS" regionBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    KOiK01885.
    OrthoDBiEOG7MKWFN.

    Family and domain databases

    Gene3Di1.10.1160.10. 1 hit.
    2.40.240.10. 2 hits.
    3.40.50.620. 2 hits.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
    IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
    IPR011035. Ribosomal_L25/Gln-tRNA_synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR10119. PTHR10119. 1 hit.
    PfamiPF00749. tRNA-synt_1c. 1 hit.
    PF03950. tRNA-synt_1c_C. 1 hit.
    [Graphical view]
    PRINTSiPR00987. TRNASYNTHGLU.
    SUPFAMiSSF50715. SSF50715. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C4VBI7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVENAINFR EICSLLDISE SYKCTINAFL DNVEKCTDKH YNDALNLLDT    50
    FFSNEVKSNS LVNDLIFCII NSNFDFLKVF KSNKLRLENL QIVYESAFNE 100
    NKPFLKEFSA KDKINKEVKK NLYSTPAVTR FAPEPSGCLH IGHLKALLVN 150
    YNLAEKSNGT LLLRFDDTNP VKNYEKYEKE ILRDLDTLGI TGLKISHSSD 200
    YFELLVDEAV SLINKNLAYV DNTDQETMRI ERFEGIESKM RNINNSESLK 250
    IFKELLQGRA PGYCLRAKID MSNPNKSMRD PVIYRASDKM HGRCKLYKAF 300
    PTYDFVCPIV DSIEGVTVVC RANEYKDRNE QYKWFLENLE LENKPEFNDF 350
    SKLNLEDTVL SKRKIDKLIS DSLVTGWDDP RLATIQGIKR LGMHMTALKD 400
    YINLQGASNK TNVISWDKIW AMNKKVIDPL SPRFMAVEKI NCVRVFITNF 450
    EGLKYTKNIP LNKKNTSLGS KDVLFSDTLL FSQEDGFVLK ENEEFTLMNW 500
    GNAIVEKKVV ENSIVTELYI KLHLEGDYKS TTNKISWVSE SGAVTATGIE 550
    YGKLLVNEEF NINSKIDKQY YVESSITNLS TDMKHVQFER IGFFYCDSPC 600
    VFHLVPFTKQ KRTY 614
    Length:614
    Mass (Da):70,755
    Last modified:July 28, 2009 - v1
    Checksum:iDD63B17BF1DEA37C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    ACOL01000581 Genomic DNA. Translation: EEQ81415.1.
    RefSeqiXP_002995086.1. XM_002995040.1.

    Genome annotation databases

    GeneIDi9423469.
    KEGGince:NCER_102160.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    ACOL01000581 Genomic DNA. Translation: EEQ81415.1 .
    RefSeqi XP_002995086.1. XM_002995040.1.

    3D structure databases

    ProteinModelPortali C4VBI7.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 9423469.
    KEGGi nce:NCER_102160.

    Organism-specific databases

    EuPathDBi MicrosporidiaDB:NCER_102160.

    Phylogenomic databases

    KOi K01885.
    OrthoDBi EOG7MKWFN.

    Family and domain databases

    Gene3Di 1.10.1160.10. 1 hit.
    2.40.240.10. 2 hits.
    3.40.50.620. 2 hits.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
    IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
    IPR011035. Ribosomal_L25/Gln-tRNA_synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR10119. PTHR10119. 1 hit.
    Pfami PF00749. tRNA-synt_1c. 1 hit.
    PF03950. tRNA-synt_1c_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00987. TRNASYNTHGLU.
    SUPFAMi SSF50715. SSF50715. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic analyses of the microsporidian Nosema ceranae, an emergent pathogen of honey bees."
      Cornman R.S., Chen Y.P., Schatz M.C., Street C., Zhao Y., Desany B., Egholm M., Hutchison S., Pettis J.S., Lipkin W.I., Evans J.D.
      PLoS Pathog. 5:E1000466-E1000466(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BRL01.

    Entry informationi

    Entry nameiSYEC_NOSCE
    AccessioniPrimary (citable) accession number: C4VBI7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 3, 2009
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 23 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3