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Protein

Probable glutamate--tRNA ligase, cytoplasmic

Gene

NCER_102160

Organism
Nosema ceranae (strain BRL01) (Microsporidian parasite)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei140ATPBy similarity1
Binding sitei166GlutamateBy similarity1
Binding sitei321GlutamateBy similarity1
Binding sitei324ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi359 – 363ATPBy similarity5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glutamate--tRNA ligase, cytoplasmic (EC:6.1.1.17)
Alternative name(s):
Glutamyl-tRNA synthetase
Short name:
GluRS
Gene namesi
ORF Names:NCER_102160
OrganismiNosema ceranae (strain BRL01) (Microsporidian parasite)
Taxonomic identifieri578460 [NCBI]
Taxonomic lineageiEukaryotaFungiFungi incertae sedisMicrosporidiaNosematidaeNosema
Proteomesi
  • UP000009082 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiMicrosporidiaDB:NCER_102160

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003883931 – 614Probable glutamate--tRNA ligase, cytoplasmicAdd BLAST614

Proteomic databases

PRIDEiC4VBI7

Structurei

3D structure databases

ProteinModelPortaliC4VBI7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni130 – 132Glutamate bindingBy similarity3
Regioni303 – 307Glutamate bindingBy similarity5

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi135 – 144"HIGH" regionBy similarity10
Motifi359 – 363"KMSKS" regionBy similarity5

Sequence similaritiesi

Phylogenomic databases

InParanoidiC4VBI7
KOiK01885
OrthoDBiEOG092C0OTH

Family and domain databases

Gene3Di2.40.240.10, 3 hits
3.40.50.620, 1 hit
HAMAPiMF_02076 Glu_tRNA_synth_type2, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR004526 Glu-tRNA-synth_arc/euk
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR020059 Glu/Gln-tRNA-synth_Ib_codon-bd
IPR020056 Rbsml_L25/Gln-tRNA_synth_N
IPR011035 Ribosomal_L25/Gln-tRNA_synth
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PF03950 tRNA-synt_1c_C, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF50715 SSF50715, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

C4VBI7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVENAINFR EICSLLDISE SYKCTINAFL DNVEKCTDKH YNDALNLLDT
60 70 80 90 100
FFSNEVKSNS LVNDLIFCII NSNFDFLKVF KSNKLRLENL QIVYESAFNE
110 120 130 140 150
NKPFLKEFSA KDKINKEVKK NLYSTPAVTR FAPEPSGCLH IGHLKALLVN
160 170 180 190 200
YNLAEKSNGT LLLRFDDTNP VKNYEKYEKE ILRDLDTLGI TGLKISHSSD
210 220 230 240 250
YFELLVDEAV SLINKNLAYV DNTDQETMRI ERFEGIESKM RNINNSESLK
260 270 280 290 300
IFKELLQGRA PGYCLRAKID MSNPNKSMRD PVIYRASDKM HGRCKLYKAF
310 320 330 340 350
PTYDFVCPIV DSIEGVTVVC RANEYKDRNE QYKWFLENLE LENKPEFNDF
360 370 380 390 400
SKLNLEDTVL SKRKIDKLIS DSLVTGWDDP RLATIQGIKR LGMHMTALKD
410 420 430 440 450
YINLQGASNK TNVISWDKIW AMNKKVIDPL SPRFMAVEKI NCVRVFITNF
460 470 480 490 500
EGLKYTKNIP LNKKNTSLGS KDVLFSDTLL FSQEDGFVLK ENEEFTLMNW
510 520 530 540 550
GNAIVEKKVV ENSIVTELYI KLHLEGDYKS TTNKISWVSE SGAVTATGIE
560 570 580 590 600
YGKLLVNEEF NINSKIDKQY YVESSITNLS TDMKHVQFER IGFFYCDSPC
610
VFHLVPFTKQ KRTY
Length:614
Mass (Da):70,755
Last modified:July 28, 2009 - v1
Checksum:iDD63B17BF1DEA37C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACOL01000581 Genomic DNA Translation: EEQ81415.1
RefSeqiXP_002995086.1, XM_002995040.1

Genome annotation databases

EnsemblFungiiEEQ81415; EEQ81415; NCER_102160
KEGGince:NCER_102160

Similar proteinsi

Entry informationi

Entry nameiSYEC_NOSCE
AccessioniPrimary (citable) accession number: C4VBI7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: July 28, 2009
Last modified: May 23, 2018
This is version 40 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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