ID   C4V992_VAIC1            Unreviewed;       430 AA.
AC   C4V992;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   27-MAR-2024, entry version 57.
DE   RecName: Full=Phosphotransferase {ECO:0000256|RuleBase:RU362007};
DE            EC=2.7.1.- {ECO:0000256|RuleBase:RU362007};
GN   ORFNames=NCER_101108 {ECO:0000313|EMBL:EEQ82213.1};
OS   Vairimorpha ceranae (strain BRL01) (Microsporidian parasite) (Nosema
OS   ceranae).
OC   Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Nosematidae;
OC   Vairimorpha.
OX   NCBI_TaxID=578460 {ECO:0000313|Proteomes:UP000009082};
RN   [1] {ECO:0000313|Proteomes:UP000009082}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BRL01 {ECO:0000313|Proteomes:UP000009082};
RX   PubMed=19503607; DOI=10.1371/journal.ppat.1000466;
RA   Cornman R.S., Chen Y.P., Schatz M.C., Street C., Zhao Y., Desany B.,
RA   Egholm M., Hutchison S., Pettis J.S., Lipkin W.I., Evans J.D.;
RT   "Genomic analyses of the microsporidian Nosema ceranae, an emergent
RT   pathogen of honey bees.";
RL   PLoS Pathog. 5:E1000466-E1000466(2009).
CC   -!- SIMILARITY: Belongs to the hexokinase family.
CC       {ECO:0000256|RuleBase:RU362007}.
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DR   EMBL; ACOL01000094; EEQ82213.1; -; Genomic_DNA.
DR   RefSeq; XP_002995884.1; XM_002995838.1.
DR   AlphaFoldDB; C4V992; -.
DR   STRING; 578460.C4V992; -.
DR   KEGG; nce:NCER_101108; -.
DR   VEuPathDB; MicrosporidiaDB:NCER_101108; -.
DR   HOGENOM; CLU_052697_0_0_1; -.
DR   InParanoid; C4V992; -.
DR   OMA; CMLGGYK; -.
DR   OrthoDB; 1341780at2759; -.
DR   Proteomes; UP000009082; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0005536; F:glucose binding; IEA:InterPro.
DR   GO; GO:0004396; F:hexokinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-KW.
DR   GO; GO:0001678; P:intracellular glucose homeostasis; IEA:InterPro.
DR   Gene3D; 3.30.420.40; -; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR001312; Hexokinase.
DR   InterPro; IPR022672; Hexokinase_N.
DR   PANTHER; PTHR19443; HEXOKINASE; 1.
DR   PANTHER; PTHR19443:SF24; HEXOKINASE YLR446W-RELATED; 1.
DR   Pfam; PF00349; Hexokinase_1; 1.
DR   PRINTS; PR00475; HEXOKINASE.
DR   SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR   PROSITE; PS51748; HEXOKINASE_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU362007};
KW   Glycolysis {ECO:0000256|RuleBase:RU362007};
KW   Kinase {ECO:0000256|RuleBase:RU362007};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU362007};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009082};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transferase {ECO:0000256|RuleBase:RU362007}.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           18..430
FT                   /note="Phosphotransferase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5002942692"
FT   DOMAIN          76..223
FT                   /note="Hexokinase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00349"
SQ   SEQUENCE   430 AA;  49177 MW;  A0A49C154FC02ADE CRC64;
     MNFFLFFYTS LVTMSSLYDV PGYTKDTLYN VYYEYQLHLT ENINNMIICD DIKQTLVEDI
     PLNVDIKKCE FNIAILDVGG SFFKIAVINI KVVDGKLKTE TTSVKNFEYP IESKNEQIFW
     YDWVSDKFVE YMLNNDIKTD LSSLIFSYPI KYKGGKSMPM ALAKHWCFEF EETLKSDLKE
     TLNHAIKNKL FDNLTSLDST VDSTGLLVNC VLNDSVATFL SSKVILDDIA IGIILGTGTN
     GSFIIKCEDK EYVYNAEWGS FVPKSLALTD EETDFINSLQ KKYNLMDILI GNGYKCGLIN
     QIIKTRSLNL IEIEGDCVKH ILQKDDDDEH KIILQKLIYR SRQLMSMLVC GSINVIKANK
     ICILLNGSGY SDDCERQALL KMIQNYAKEI CDLDVEIKIH YEEGLTFIGA AYYSLVKFLN
     ENVKPKKTMN
//