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C4V8Q1

- SYIC_NOSCE

UniProt

C4V8Q1 - SYIC_NOSCE

Protein

Probable isoleucine--tRNA ligase, cytoplasmic

Gene

NCER_100885

Organism
Nosema ceranae (strain BRL01) (Microsporidian parasite)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 31 (01 Oct 2014)
      Sequence version 1 (28 Jul 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei618 – 6181ATPBy similarity

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-KW
    3. isoleucine-tRNA ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. isoleucyl-tRNA aminoacylation Source: InterPro

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable isoleucine--tRNA ligase, cytoplasmic (EC:6.1.1.5)
    Alternative name(s):
    Isoleucyl-tRNA synthetase
    Short name:
    IleRS
    Gene namesi
    ORF Names:NCER_100885
    OrganismiNosema ceranae (strain BRL01) (Microsporidian parasite)
    Taxonomic identifieri578460 [NCBI]
    Taxonomic lineageiEukaryotaFungiMicrosporidiaNosematidaeNosema
    ProteomesiUP000009082: Unassembled WGS sequence

    Organism-specific databases

    EuPathDBiMicrosporidiaDB:NCER_100885.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10461046Probable isoleucine--tRNA ligase, cytoplasmicPRO_0000388380Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliC4V8Q1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi46 – 5611"HIGH" regionBy similarityAdd
    BLAST
    Motifi615 – 6195"KMSKS" regionBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    KOiK01870.
    OrthoDBiEOG7FNCGS.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    InterProiIPR002300. aa-tRNA-synth_Ia.
    IPR002301. Ile-tRNA-ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    [Graphical view]
    PRINTSiPR00984. TRNASYNTHILE.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00392. ileS. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C4V8Q1-1 [UniParc]FASTAAdd to Basket

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    MKFDSNLSIN DIETKILKFW KDTKCFKKSN ELSKNKKKYT FYDGPPFATG     50
    LPHFGHILAG TVKDVITRYQ YQHNKRVDRR FGWDCHGLPV EFEIDKNLGI 100
    SVKQEILEMG IDKYNAECKS IVMKHSSEWK DTVEKMGRWV DFDNSYKTMD 150
    LSFMTSVWYV FSQLYKKGYV YRGYRVMPFS TGCMTTLSSS EAKSNYKMVN 200
    DLSVVVEFPL KSKLFDKKVS ILAWTTTPWT LPSNCGLVVN KDFDYQIFEI 250
    DHKFYCMLPN RIQDFNKKEV ILHELFKGEL LIGLEYEQPF NYFEEYRRCG 300
    FFKIIGGSFV SSTDGTGIVH AAPAFGEDDY NCFVENNLIK QNDLVPCPVD 350
    ENGKFTAEVF DYKGIYVKDA DKLIIKHLKE KIFCVKQISH NYPFCWRSEK 400
    PLIYRLVSSW FIKVSDSVDK LIKNNEIINW VPKDIKHKKF GKWLSNAKDW 450
    AFSRSRFWGT PIPLWVSDDY SEILCVESAE ELEKLSGKKI TDLHMEFIDD 500
    IILTKNGKTL RRIPEVFDCW FESGCMPYAQ HSWPFRKVDN LNCEEIRHHF 550
    HDSDNTLVYE NKILENFPAD FIGEGIDQTR GWFYTLHVIS TLLFDKPAFK 600
    NVIVNGIVLA ENGKKMSKKD KNYPDPNIVM KTFGADSLRM YLISSPVVEA 650
    DNLLFKEDGV KDVSKLLIIP WMNVLKFYTT SLQKRNDCEK LELDNWINYT 700
    FNEFLSSVSN YMNNYQLSKV CGLAYKFLDN LSNWYLRIHR EEIRSGNTKI 750
    LFNILKKFSV IMSPFAPFFS EYSFQCLLSS QQNEKSNSIN SVHFQMYPEA 800
    QDSGDNSFEN AKDIIDAIRY LRDKHTISLK TPLKEVKIIS DELFMKDAAK 850
    FSNTIIRECH VFNLIFVKES EVPELKIEYK AKPCFEYLKK DLKTMNDKIK 900
    IINKLTQSEI RDLAFLDLSE EKYNVKRENI LIEKKATFPT GLCFASNKFV 950
    ILVDNTIDDN VLEKKLAREF NSFIQKLRKS CGLKMNDTVN VEVDSEKIKQ 1000
    ITKKFYPINF STEGQIVSPI DSDAQIDVFS YEGQELKVIL RLNKFL 1046
    Length:1,046
    Mass (Da):122,145
    Last modified:July 28, 2009 - v1
    Checksum:iB2FCC7669CD0CEF7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    ACOL01000062 Genomic DNA. Translation: EEQ82400.1.
    RefSeqiXP_002996071.1. XM_002996025.1.

    Genome annotation databases

    GeneIDi9422100.
    KEGGince:NCER_100885.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    ACOL01000062 Genomic DNA. Translation: EEQ82400.1 .
    RefSeqi XP_002996071.1. XM_002996025.1.

    3D structure databases

    ProteinModelPortali C4V8Q1.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 9422100.
    KEGGi nce:NCER_100885.

    Organism-specific databases

    EuPathDBi MicrosporidiaDB:NCER_100885.

    Phylogenomic databases

    KOi K01870.
    OrthoDBi EOG7FNCGS.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    InterProi IPR002300. aa-tRNA-synth_Ia.
    IPR002301. Ile-tRNA-ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00984. TRNASYNTHILE.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00392. ileS. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genomic analyses of the microsporidian Nosema ceranae, an emergent pathogen of honey bees."
      Cornman R.S., Chen Y.P., Schatz M.C., Street C., Zhao Y., Desany B., Egholm M., Hutchison S., Pettis J.S., Lipkin W.I., Evans J.D.
      PLoS Pathog. 5:E1000466-E1000466(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BRL01.

    Entry informationi

    Entry nameiSYIC_NOSCE
    AccessioniPrimary (citable) accession number: C4V8Q1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 3, 2009
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 31 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3