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C4V8L1

- SYLC_NOSCE

UniProt

C4V8L1 - SYLC_NOSCE

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Protein
Probable leucine--tRNA ligase, cytoplasmic
Gene
NCER_100842
Organism
Nosema ceranae (strain BRL01) (Microsporidian parasite)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei569 – 5691ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. leucine-tRNA ligase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. tRNA aminoacylation for protein translation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable leucine--tRNA ligase, cytoplasmic (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
ORF Names:NCER_100842
OrganismiNosema ceranae (strain BRL01) (Microsporidian parasite)
Taxonomic identifieri578460 [NCBI]
Taxonomic lineageiEukaryotaFungiMicrosporidiaNosematidaeNosema
ProteomesiUP000009082: Unassembled WGS sequence

Organism-specific databases

EuPathDBiMicrosporidiaDB:NCER_100842.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 884884Probable leucine--tRNA ligase, cytoplasmic
PRO_0000388415Add
BLAST

Proteomic databases

PRIDEiC4V8L1.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5011"HIGH" region By similarity
Add
BLAST
Motifi566 – 5705"KMSKS" region By similarity

Sequence similaritiesi

Phylogenomic databases

KOiK01869.
OrthoDBiEOG7TTQH2.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PfamiPF00133. tRNA-synt_1. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C4V8L1-1 [UniParc]FASTAAdd to Basket

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MNCNEHESTK LNYLNSLEKS RDVKTDISDK PKYFITFPYP YMNGKLHLGH    50
LYSISKADFM SYYKELQGFN VLFPLAFHCT GMPIAALAKK LGEELEGKKT 100
DISTKEIIQN LGFNDVMPFT DPVHWIKTFP KLCISSLKTF GANIDWRRSF 150
VTTDINKYYD SFVRWQFFNL KELGYLSFGK RHSIYCPLDK QMCLDHDRRK 200
GENIKPVRQI MFKFHLHDKI LLVRQNSIGK PYKLVCGKSL EVVSFKYNNT 250
SFLAEKIIFD NLKYQINNVK YKESLVLSMD LKDGLTYDGT NIEVEVIEKN 300
ILVVKTDTKS DVELYEKEIK ALNEIEETLF TLSTSSEGIV ESVAKLSVEN 350
TKDLLVQTKH FISVYIPEKE VISRSGGICV VSLLDQWYID YSNEKWKSKV 400
KKCLDNLECG PDTRSMLYAG IDWVNKWGFS RSFGLGTKIP WDTQYLIDSL 450
SDSTIYMAFY TVKHLLFEDL EGKLEIFPSN KLSNDVWDYI FAGKDLVPEL 500
YGYLDLLEKC RNNFQYFYPV DLRVSGKDLI KNHLLFFMFN HVALFDEKYW 550
PKRIFTNGHL MLNKEKMSKS TGNFLSVDDA LLKYGKSATR MCLAVCGDTN 600
DDANFVEDNA NLFILKIYTF VKEIQKLNEL VRKKSENETI ASYSNADVLL 650
LETVSVNVTE ALNAYNSMKY SDVVKFSFFE MVNLINLYNN INGTNILLKN 700
LVYKSATQLL YPIMPDLCRT LIEKYFDSEF NLPEPKLKTN KMISAFEYIS 750
ELIKKIAASK QAKNNSCVKI AVGKNYSEWK KEIFELIDKI DCPRNNEIKK 800
NKVFIASLLD SVKPILQKSK INITKGNNFV MDYLVNPDKF VMKFNEYEII 850
NEFKFYIENM SNKKAILEEH CDAEPLNPII TFSK 884
Length:884
Mass (Da):102,520
Last modified:July 28, 2009 - v1
Checksum:i909334958DC35622
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
ACOL01000057 Genomic DNA. Translation: EEQ82449.1.
RefSeqiXP_002996120.1. XM_002996074.1.

Genome annotation databases

GeneIDi9424018.
KEGGince:NCER_100842.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
ACOL01000057 Genomic DNA. Translation: EEQ82449.1 .
RefSeqi XP_002996120.1. XM_002996074.1.

3D structure databases

ModBasei Search...

Proteomic databases

PRIDEi C4V8L1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 9424018.
KEGGi nce:NCER_100842.

Organism-specific databases

EuPathDBi MicrosporidiaDB:NCER_100842.

Phylogenomic databases

KOi K01869.
OrthoDBi EOG7TTQH2.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view ]
Pfami PF00133. tRNA-synt_1. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
SUPFAMi SSF47323. SSF47323. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genomic analyses of the microsporidian Nosema ceranae, an emergent pathogen of honey bees."
    Cornman R.S., Chen Y.P., Schatz M.C., Street C., Zhao Y., Desany B., Egholm M., Hutchison S., Pettis J.S., Lipkin W.I., Evans J.D.
    PLoS Pathog. 5:E1000466-E1000466(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BRL01.

Entry informationi

Entry nameiSYLC_NOSCE
AccessioniPrimary (citable) accession number: C4V8L1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: July 28, 2009
Last modified: April 16, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi