Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable leucine--tRNA ligase, cytoplasmic

Gene

NCER_100842

Organism
Nosema ceranae (strain BRL01) (Microsporidian parasite)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei569ATPBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable leucine--tRNA ligase, cytoplasmic (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
ORF Names:NCER_100842
OrganismiNosema ceranae (strain BRL01) (Microsporidian parasite)
Taxonomic identifieri578460 [NCBI]
Taxonomic lineageiEukaryotaFungiFungi incertae sedisMicrosporidiaNosematidaeNosema
Proteomesi
  • UP000009082 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiMicrosporidiaDB:NCER_100842

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003884151 – 884Probable leucine--tRNA ligase, cytoplasmicAdd BLAST884

Proteomic databases

PRIDEiC4V8L1

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi40 – 50"HIGH" regionBy similarityAdd BLAST11
Motifi566 – 570"KMSKS" regionBy similarity5

Sequence similaritiesi

Phylogenomic databases

InParanoidiC4V8L1
KOiK01869
OrthoDBiEOG092C097K

Family and domain databases

Gene3Di3.40.50.620, 2 hits
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR004493 Leu-tRNA-synth_Ia_arc/euk
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
PANTHERiPTHR11946:SF51 PTHR11946:SF51, 1 hit
PfamiView protein in Pfam
PF00133 tRNA-synt_1, 1 hit
PF09334 tRNA-synt_1g, 1 hit
SUPFAMiSSF47323 SSF47323, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

C4V8L1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNCNEHESTK LNYLNSLEKS RDVKTDISDK PKYFITFPYP YMNGKLHLGH
60 70 80 90 100
LYSISKADFM SYYKELQGFN VLFPLAFHCT GMPIAALAKK LGEELEGKKT
110 120 130 140 150
DISTKEIIQN LGFNDVMPFT DPVHWIKTFP KLCISSLKTF GANIDWRRSF
160 170 180 190 200
VTTDINKYYD SFVRWQFFNL KELGYLSFGK RHSIYCPLDK QMCLDHDRRK
210 220 230 240 250
GENIKPVRQI MFKFHLHDKI LLVRQNSIGK PYKLVCGKSL EVVSFKYNNT
260 270 280 290 300
SFLAEKIIFD NLKYQINNVK YKESLVLSMD LKDGLTYDGT NIEVEVIEKN
310 320 330 340 350
ILVVKTDTKS DVELYEKEIK ALNEIEETLF TLSTSSEGIV ESVAKLSVEN
360 370 380 390 400
TKDLLVQTKH FISVYIPEKE VISRSGGICV VSLLDQWYID YSNEKWKSKV
410 420 430 440 450
KKCLDNLECG PDTRSMLYAG IDWVNKWGFS RSFGLGTKIP WDTQYLIDSL
460 470 480 490 500
SDSTIYMAFY TVKHLLFEDL EGKLEIFPSN KLSNDVWDYI FAGKDLVPEL
510 520 530 540 550
YGYLDLLEKC RNNFQYFYPV DLRVSGKDLI KNHLLFFMFN HVALFDEKYW
560 570 580 590 600
PKRIFTNGHL MLNKEKMSKS TGNFLSVDDA LLKYGKSATR MCLAVCGDTN
610 620 630 640 650
DDANFVEDNA NLFILKIYTF VKEIQKLNEL VRKKSENETI ASYSNADVLL
660 670 680 690 700
LETVSVNVTE ALNAYNSMKY SDVVKFSFFE MVNLINLYNN INGTNILLKN
710 720 730 740 750
LVYKSATQLL YPIMPDLCRT LIEKYFDSEF NLPEPKLKTN KMISAFEYIS
760 770 780 790 800
ELIKKIAASK QAKNNSCVKI AVGKNYSEWK KEIFELIDKI DCPRNNEIKK
810 820 830 840 850
NKVFIASLLD SVKPILQKSK INITKGNNFV MDYLVNPDKF VMKFNEYEII
860 870 880
NEFKFYIENM SNKKAILEEH CDAEPLNPII TFSK
Length:884
Mass (Da):102,520
Last modified:July 28, 2009 - v1
Checksum:i909334958DC35622
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACOL01000057 Genomic DNA Translation: EEQ82449.1
RefSeqiXP_002996120.1, XM_002996074.1

Genome annotation databases

EnsemblFungiiEEQ82449; EEQ82449; NCER_100842
KEGGince:NCER_100842

Similar proteinsi

Entry informationi

Entry nameiSYLC_NOSCE
AccessioniPrimary (citable) accession number: C4V8L1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: July 28, 2009
Last modified: May 23, 2018
This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health