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C4V8L1

- SYLC_NOSCE

UniProt

C4V8L1 - SYLC_NOSCE

Protein

Probable leucine--tRNA ligase, cytoplasmic

Gene

NCER_100842

Organism
Nosema ceranae (strain BRL01) (Microsporidian parasite)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 23 (01 Oct 2014)
      Sequence version 1 (28 Jul 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei569 – 5691ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. leucine-tRNA ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. tRNA aminoacylation for protein translation Source: InterPro

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable leucine--tRNA ligase, cytoplasmic (EC:6.1.1.4)
    Alternative name(s):
    Leucyl-tRNA synthetase
    Short name:
    LeuRS
    Gene namesi
    ORF Names:NCER_100842
    OrganismiNosema ceranae (strain BRL01) (Microsporidian parasite)
    Taxonomic identifieri578460 [NCBI]
    Taxonomic lineageiEukaryotaFungiMicrosporidiaNosematidaeNosema
    ProteomesiUP000009082: Unassembled WGS sequence

    Organism-specific databases

    EuPathDBiMicrosporidiaDB:NCER_100842.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 884884Probable leucine--tRNA ligase, cytoplasmicPRO_0000388415Add
    BLAST

    Proteomic databases

    PRIDEiC4V8L1.

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi40 – 5011"HIGH" regionBy similarityAdd
    BLAST
    Motifi566 – 5705"KMSKS" regionBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    KOiK01869.
    OrthoDBiEOG7TTQH2.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    [Graphical view]
    PfamiPF00133. tRNA-synt_1. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    SUPFAMiSSF47323. SSF47323. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C4V8L1-1 [UniParc]FASTAAdd to Basket

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    MNCNEHESTK LNYLNSLEKS RDVKTDISDK PKYFITFPYP YMNGKLHLGH    50
    LYSISKADFM SYYKELQGFN VLFPLAFHCT GMPIAALAKK LGEELEGKKT 100
    DISTKEIIQN LGFNDVMPFT DPVHWIKTFP KLCISSLKTF GANIDWRRSF 150
    VTTDINKYYD SFVRWQFFNL KELGYLSFGK RHSIYCPLDK QMCLDHDRRK 200
    GENIKPVRQI MFKFHLHDKI LLVRQNSIGK PYKLVCGKSL EVVSFKYNNT 250
    SFLAEKIIFD NLKYQINNVK YKESLVLSMD LKDGLTYDGT NIEVEVIEKN 300
    ILVVKTDTKS DVELYEKEIK ALNEIEETLF TLSTSSEGIV ESVAKLSVEN 350
    TKDLLVQTKH FISVYIPEKE VISRSGGICV VSLLDQWYID YSNEKWKSKV 400
    KKCLDNLECG PDTRSMLYAG IDWVNKWGFS RSFGLGTKIP WDTQYLIDSL 450
    SDSTIYMAFY TVKHLLFEDL EGKLEIFPSN KLSNDVWDYI FAGKDLVPEL 500
    YGYLDLLEKC RNNFQYFYPV DLRVSGKDLI KNHLLFFMFN HVALFDEKYW 550
    PKRIFTNGHL MLNKEKMSKS TGNFLSVDDA LLKYGKSATR MCLAVCGDTN 600
    DDANFVEDNA NLFILKIYTF VKEIQKLNEL VRKKSENETI ASYSNADVLL 650
    LETVSVNVTE ALNAYNSMKY SDVVKFSFFE MVNLINLYNN INGTNILLKN 700
    LVYKSATQLL YPIMPDLCRT LIEKYFDSEF NLPEPKLKTN KMISAFEYIS 750
    ELIKKIAASK QAKNNSCVKI AVGKNYSEWK KEIFELIDKI DCPRNNEIKK 800
    NKVFIASLLD SVKPILQKSK INITKGNNFV MDYLVNPDKF VMKFNEYEII 850
    NEFKFYIENM SNKKAILEEH CDAEPLNPII TFSK 884
    Length:884
    Mass (Da):102,520
    Last modified:July 28, 2009 - v1
    Checksum:i909334958DC35622
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    ACOL01000057 Genomic DNA. Translation: EEQ82449.1.
    RefSeqiXP_002996120.1. XM_002996074.1.

    Genome annotation databases

    GeneIDi9424018.
    KEGGince:NCER_100842.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    ACOL01000057 Genomic DNA. Translation: EEQ82449.1 .
    RefSeqi XP_002996120.1. XM_002996074.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi C4V8L1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 9424018.
    KEGGi nce:NCER_100842.

    Organism-specific databases

    EuPathDBi MicrosporidiaDB:NCER_100842.

    Phylogenomic databases

    KOi K01869.
    OrthoDBi EOG7TTQH2.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    [Graphical view ]
    Pfami PF00133. tRNA-synt_1. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47323. SSF47323. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic analyses of the microsporidian Nosema ceranae, an emergent pathogen of honey bees."
      Cornman R.S., Chen Y.P., Schatz M.C., Street C., Zhao Y., Desany B., Egholm M., Hutchison S., Pettis J.S., Lipkin W.I., Evans J.D.
      PLoS Pathog. 5:E1000466-E1000466(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BRL01.

    Entry informationi

    Entry nameiSYLC_NOSCE
    AccessioniPrimary (citable) accession number: C4V8L1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 3, 2009
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 23 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3