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C4V8K5

- IF4G_NOSCE

UniProt

C4V8K5 - IF4G_NOSCE

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Protein

Probable eukaryotic translation initiation factor 4 gamma homolog

Gene
EIF4G, NCER_100836
Organism
Nosema ceranae (strain BRL01) (Microsporidian parasite)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome By similarity.

GO - Molecular functioni

  1. translation initiation factor activity Source: UniProtKB-KW

GO - Biological processi

  1. regulation of translation Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis, Translation regulation

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable eukaryotic translation initiation factor 4 gamma homolog
Short name:
eIF-4-gamma
Gene namesi
Name:EIF4G
ORF Names:NCER_100836
OrganismiNosema ceranae (strain BRL01) (Microsporidian parasite)
Taxonomic identifieri578460 [NCBI]
Taxonomic lineageiEukaryotaFungiMicrosporidiaNosematidaeNosema
ProteomesiUP000009082: Unassembled WGS sequence

Organism-specific databases

EuPathDBiMicrosporidiaDB:NCER_100836.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 598598Probable eukaryotic translation initiation factor 4 gamma homologPRO_0000388437Add
BLAST

Interactioni

Subunit structurei

Component of the eIF4F complex, which composition varies with external and internal environmental conditions By similarity.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini209 – 434226MIF4GAdd
BLAST

Sequence similaritiesi

Contains 1 MIF4G domain.

Phylogenomic databases

KOiK03260.
OrthoDBiEOG7NW6K2.

Family and domain databases

Gene3Di1.25.40.180. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR016021. MIF4-like_typ_1/2/3.
IPR003890. MIF4G-like_typ-3.
[Graphical view]
PfamiPF02854. MIF4G. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequencei

Sequence statusi: Complete.

C4V8K5-1 [UniParc]FASTAAdd to Basket

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MVNEVPTLKK KIIFKYFKPL LTFTKKEDPY ELRVKSAPPL NIIEERKEPK    50
KFVLCKPDGT PITLDDLSDI SDSEEEEDTK LDMKDSIKED VKDSIKEDVK 100
DSSKEDVKDD VIEDVKGSIN EEINSTCGTC SFINLKREKI LNELLEMYRV 150
EESVPYSFVP TNVPQIMYSV GEILNCINKI PFTLKLLKKD VNKIPVNYKE 200
FKINKETIIE KATFELNKLT NTNIKRIITN LKNLNIETIQ QAKYLGNLIV 250
FKAINEPQYC NLYAMVVGAL KKDFKSKEEL GLHKKQTAFF GTVLTSAMKV 300
LEEKVEWADT KVLDKNLYKN AFEYERAFEE QETERYLRKK KTLGAVNLLC 350
DLYNLDVITL KHIQSRLNEF LNIENEEVVE VLGKFIEKIG EKMYLNDKSD 400
YANMICSYLD ACKNKYSNRV KFYIMDVLDK KKNWKKPVSK TENLFSSLIM 450
EDEPALDTPY QYQEQVIANE EEEDSLELLK TIDNIYQDLK DAYDEEDEIM 500
IADNFKIASN TFGKISFFST YFSECITNSR KSKLLVPFVI NFFNETNLNE 550
SELFDIINKH KEKLNELKID FPLSQKIMSL YVINFVVDRL SKKIHMIN 598
Length:598
Mass (Da):69,759
Last modified:July 28, 2009 - v1
Checksum:i0098C68E1D101797
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
ACOL01000057 Genomic DNA. Translation: EEQ82443.1.
RefSeqiXP_002996114.1. XM_002996068.1.

Genome annotation databases

GeneIDi9424012.
KEGGince:NCER_100836.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
ACOL01000057 Genomic DNA. Translation: EEQ82443.1 .
RefSeqi XP_002996114.1. XM_002996068.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 9424012.
KEGGi nce:NCER_100836.

Organism-specific databases

EuPathDBi MicrosporidiaDB:NCER_100836.

Phylogenomic databases

KOi K03260.
OrthoDBi EOG7NW6K2.

Family and domain databases

Gene3Di 1.25.40.180. 1 hit.
InterProi IPR016024. ARM-type_fold.
IPR016021. MIF4-like_typ_1/2/3.
IPR003890. MIF4G-like_typ-3.
[Graphical view ]
Pfami PF02854. MIF4G. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genomic analyses of the microsporidian Nosema ceranae, an emergent pathogen of honey bees."
    Cornman R.S., Chen Y.P., Schatz M.C., Street C., Zhao Y., Desany B., Egholm M., Hutchison S., Pettis J.S., Lipkin W.I., Evans J.D.
    PLoS Pathog. 5:E1000466-E1000466(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BRL01.

Entry informationi

Entry nameiIF4G_NOSCE
AccessioniPrimary (citable) accession number: C4V8K5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: July 28, 2009
Last modified: December 11, 2013
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3