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C4V8K5 (IF4G_NOSCE) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 24. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable eukaryotic translation initiation factor 4 gamma homolog

Short name=eIF-4-gamma
Gene names
Name:EIF4G
ORF Names:NCER_100836
OrganismNosema ceranae (strain BRL01) (Microsporidian parasite) [Complete proteome]
Taxonomic identifier578460 [NCBI]
Taxonomic lineageEukaryotaFungiMicrosporidiaNosematidaeNosema

Protein attributes

Sequence length598 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome By similarity.

Subunit structure

Component of the eIF4F complex, which composition varies with external and internal environmental conditions By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the eukaryotic initiation factor 4G family.

Contains 1 MIF4G domain.

Ontologies

Keywords
   Biological processProtein biosynthesis
Translation regulation
   Cellular componentCytoplasm
   LigandRNA-binding
   Molecular functionInitiation factor
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processregulation of translation

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functiontranslation initiation factor activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 598598Probable eukaryotic translation initiation factor 4 gamma homolog
PRO_0000388437

Regions

Domain209 – 434226MIF4G

Sequences

Sequence LengthMass (Da)Tools
C4V8K5 [UniParc].

Last modified July 28, 2009. Version 1.
Checksum: 0098C68E1D101797

FASTA59869,759
        10         20         30         40         50         60 
MVNEVPTLKK KIIFKYFKPL LTFTKKEDPY ELRVKSAPPL NIIEERKEPK KFVLCKPDGT 

        70         80         90        100        110        120 
PITLDDLSDI SDSEEEEDTK LDMKDSIKED VKDSIKEDVK DSSKEDVKDD VIEDVKGSIN 

       130        140        150        160        170        180 
EEINSTCGTC SFINLKREKI LNELLEMYRV EESVPYSFVP TNVPQIMYSV GEILNCINKI 

       190        200        210        220        230        240 
PFTLKLLKKD VNKIPVNYKE FKINKETIIE KATFELNKLT NTNIKRIITN LKNLNIETIQ 

       250        260        270        280        290        300 
QAKYLGNLIV FKAINEPQYC NLYAMVVGAL KKDFKSKEEL GLHKKQTAFF GTVLTSAMKV 

       310        320        330        340        350        360 
LEEKVEWADT KVLDKNLYKN AFEYERAFEE QETERYLRKK KTLGAVNLLC DLYNLDVITL 

       370        380        390        400        410        420 
KHIQSRLNEF LNIENEEVVE VLGKFIEKIG EKMYLNDKSD YANMICSYLD ACKNKYSNRV 

       430        440        450        460        470        480 
KFYIMDVLDK KKNWKKPVSK TENLFSSLIM EDEPALDTPY QYQEQVIANE EEEDSLELLK 

       490        500        510        520        530        540 
TIDNIYQDLK DAYDEEDEIM IADNFKIASN TFGKISFFST YFSECITNSR KSKLLVPFVI 

       550        560        570        580        590 
NFFNETNLNE SELFDIINKH KEKLNELKID FPLSQKIMSL YVINFVVDRL SKKIHMIN 

« Hide

References

[1]"Genomic analyses of the microsporidian Nosema ceranae, an emergent pathogen of honey bees."
Cornman R.S., Chen Y.P., Schatz M.C., Street C., Zhao Y., Desany B., Egholm M., Hutchison S., Pettis J.S., Lipkin W.I., Evans J.D.
PLoS Pathog. 5:E1000466-E1000466(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: BRL01.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
ACOL01000057 Genomic DNA. Translation: EEQ82443.1.
RefSeqXP_002996114.1. XM_002996068.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID9424012.
KEGGnce:NCER_100836.

Organism-specific databases

EuPathDBMicrosporidiaDB:NCER_100836.

Phylogenomic databases

KOK03260.
OrthoDBEOG7NW6K2.

Family and domain databases

Gene3D1.25.40.180. 1 hit.
InterProIPR016024. ARM-type_fold.
IPR016021. MIF4-like_typ_1/2/3.
IPR003890. MIF4G-like_typ-3.
[Graphical view]
PfamPF02854. MIF4G. 1 hit.
[Graphical view]
SUPFAMSSF48371. SSF48371. 1 hit.
ProtoNetSearch...

Entry information

Entry nameIF4G_NOSCE
AccessionPrimary (citable) accession number: C4V8K5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: July 28, 2009
Last modified: December 11, 2013
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families