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C4V8K5

- IF4G_NOSCE

UniProt

C4V8K5 - IF4G_NOSCE

Protein

Probable eukaryotic translation initiation factor 4 gamma homolog

Gene

EIF4G

Organism
Nosema ceranae (strain BRL01) (Microsporidian parasite)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 25 (01 Oct 2014)
      Sequence version 1 (28 Jul 2009)
      Previous versions | rss
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    Functioni

    Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome.By similarity

    GO - Molecular functioni

    1. translation initiation factor activity Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of translation Source: UniProtKB-KW

    Keywords - Molecular functioni

    Initiation factor

    Keywords - Biological processi

    Protein biosynthesis, Translation regulation

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable eukaryotic translation initiation factor 4 gamma homolog
    Short name:
    eIF-4-gamma
    Gene namesi
    Name:EIF4G
    ORF Names:NCER_100836
    OrganismiNosema ceranae (strain BRL01) (Microsporidian parasite)
    Taxonomic identifieri578460 [NCBI]
    Taxonomic lineageiEukaryotaFungiMicrosporidiaNosematidaeNosema
    ProteomesiUP000009082: Unassembled WGS sequence

    Organism-specific databases

    EuPathDBiMicrosporidiaDB:NCER_100836.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 598598Probable eukaryotic translation initiation factor 4 gamma homologPRO_0000388437Add
    BLAST

    Interactioni

    Subunit structurei

    Component of the eIF4F complex, which composition varies with external and internal environmental conditions.By similarity

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini209 – 434226MIF4GAdd
    BLAST

    Sequence similaritiesi

    Contains 1 MIF4G domain.Curated

    Phylogenomic databases

    KOiK03260.
    OrthoDBiEOG7NW6K2.

    Family and domain databases

    Gene3Di1.25.40.180. 1 hit.
    InterProiIPR016024. ARM-type_fold.
    IPR016021. MIF4-like_typ_1/2/3.
    IPR003890. MIF4G-like_typ-3.
    [Graphical view]
    PfamiPF02854. MIF4G. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C4V8K5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVNEVPTLKK KIIFKYFKPL LTFTKKEDPY ELRVKSAPPL NIIEERKEPK    50
    KFVLCKPDGT PITLDDLSDI SDSEEEEDTK LDMKDSIKED VKDSIKEDVK 100
    DSSKEDVKDD VIEDVKGSIN EEINSTCGTC SFINLKREKI LNELLEMYRV 150
    EESVPYSFVP TNVPQIMYSV GEILNCINKI PFTLKLLKKD VNKIPVNYKE 200
    FKINKETIIE KATFELNKLT NTNIKRIITN LKNLNIETIQ QAKYLGNLIV 250
    FKAINEPQYC NLYAMVVGAL KKDFKSKEEL GLHKKQTAFF GTVLTSAMKV 300
    LEEKVEWADT KVLDKNLYKN AFEYERAFEE QETERYLRKK KTLGAVNLLC 350
    DLYNLDVITL KHIQSRLNEF LNIENEEVVE VLGKFIEKIG EKMYLNDKSD 400
    YANMICSYLD ACKNKYSNRV KFYIMDVLDK KKNWKKPVSK TENLFSSLIM 450
    EDEPALDTPY QYQEQVIANE EEEDSLELLK TIDNIYQDLK DAYDEEDEIM 500
    IADNFKIASN TFGKISFFST YFSECITNSR KSKLLVPFVI NFFNETNLNE 550
    SELFDIINKH KEKLNELKID FPLSQKIMSL YVINFVVDRL SKKIHMIN 598
    Length:598
    Mass (Da):69,759
    Last modified:July 28, 2009 - v1
    Checksum:i0098C68E1D101797
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    ACOL01000057 Genomic DNA. Translation: EEQ82443.1.
    RefSeqiXP_002996114.1. XM_002996068.1.

    Genome annotation databases

    GeneIDi9424012.
    KEGGince:NCER_100836.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    ACOL01000057 Genomic DNA. Translation: EEQ82443.1 .
    RefSeqi XP_002996114.1. XM_002996068.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 9424012.
    KEGGi nce:NCER_100836.

    Organism-specific databases

    EuPathDBi MicrosporidiaDB:NCER_100836.

    Phylogenomic databases

    KOi K03260.
    OrthoDBi EOG7NW6K2.

    Family and domain databases

    Gene3Di 1.25.40.180. 1 hit.
    InterProi IPR016024. ARM-type_fold.
    IPR016021. MIF4-like_typ_1/2/3.
    IPR003890. MIF4G-like_typ-3.
    [Graphical view ]
    Pfami PF02854. MIF4G. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genomic analyses of the microsporidian Nosema ceranae, an emergent pathogen of honey bees."
      Cornman R.S., Chen Y.P., Schatz M.C., Street C., Zhao Y., Desany B., Egholm M., Hutchison S., Pettis J.S., Lipkin W.I., Evans J.D.
      PLoS Pathog. 5:E1000466-E1000466(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BRL01.

    Entry informationi

    Entry nameiIF4G_NOSCE
    AccessioniPrimary (citable) accession number: C4V8K5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 3, 2009
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 25 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3