Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable eukaryotic translation initiation factor 4 gamma homolog

Gene

EIF4G

Organism
Nosema ceranae (strain BRL01) (Microsporidian parasite)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome.By similarity

GO - Molecular functioni

  1. translation initiation factor activity Source: UniProtKB-KW

GO - Biological processi

  1. regulation of translation Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis, Translation regulation

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable eukaryotic translation initiation factor 4 gamma homolog
Short name:
eIF-4-gamma
Gene namesi
Name:EIF4G
ORF Names:NCER_100836
OrganismiNosema ceranae (strain BRL01) (Microsporidian parasite)
Taxonomic identifieri578460 [NCBI]
Taxonomic lineageiEukaryotaFungiMicrosporidiaNosematidaeNosema
ProteomesiUP000009082: Unassembled WGS sequence

Organism-specific databases

EuPathDBiMicrosporidiaDB:NCER_100836.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 598598Probable eukaryotic translation initiation factor 4 gamma homologPRO_0000388437Add
BLAST

Interactioni

Subunit structurei

Component of the eIF4F complex, which composition varies with external and internal environmental conditions.By similarity

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini209 – 434226MIF4GAdd
BLAST

Sequence similaritiesi

Contains 1 MIF4G domain.Curated

Phylogenomic databases

InParanoidiC4V8K5.
KOiK03260.
OrthoDBiEOG7NW6K2.

Family and domain databases

Gene3Di1.25.40.180. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR016021. MIF4-like_typ_1/2/3.
IPR003890. MIF4G-like_typ-3.
[Graphical view]
PfamiPF02854. MIF4G. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequencei

Sequence statusi: Complete.

C4V8K5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVNEVPTLKK KIIFKYFKPL LTFTKKEDPY ELRVKSAPPL NIIEERKEPK
60 70 80 90 100
KFVLCKPDGT PITLDDLSDI SDSEEEEDTK LDMKDSIKED VKDSIKEDVK
110 120 130 140 150
DSSKEDVKDD VIEDVKGSIN EEINSTCGTC SFINLKREKI LNELLEMYRV
160 170 180 190 200
EESVPYSFVP TNVPQIMYSV GEILNCINKI PFTLKLLKKD VNKIPVNYKE
210 220 230 240 250
FKINKETIIE KATFELNKLT NTNIKRIITN LKNLNIETIQ QAKYLGNLIV
260 270 280 290 300
FKAINEPQYC NLYAMVVGAL KKDFKSKEEL GLHKKQTAFF GTVLTSAMKV
310 320 330 340 350
LEEKVEWADT KVLDKNLYKN AFEYERAFEE QETERYLRKK KTLGAVNLLC
360 370 380 390 400
DLYNLDVITL KHIQSRLNEF LNIENEEVVE VLGKFIEKIG EKMYLNDKSD
410 420 430 440 450
YANMICSYLD ACKNKYSNRV KFYIMDVLDK KKNWKKPVSK TENLFSSLIM
460 470 480 490 500
EDEPALDTPY QYQEQVIANE EEEDSLELLK TIDNIYQDLK DAYDEEDEIM
510 520 530 540 550
IADNFKIASN TFGKISFFST YFSECITNSR KSKLLVPFVI NFFNETNLNE
560 570 580 590
SELFDIINKH KEKLNELKID FPLSQKIMSL YVINFVVDRL SKKIHMIN
Length:598
Mass (Da):69,759
Last modified:July 28, 2009 - v1
Checksum:i0098C68E1D101797
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACOL01000057 Genomic DNA. Translation: EEQ82443.1.
RefSeqiXP_002996114.1. XM_002996068.1.

Genome annotation databases

GeneIDi9424012.
KEGGince:NCER_100836.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACOL01000057 Genomic DNA. Translation: EEQ82443.1.
RefSeqiXP_002996114.1. XM_002996068.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi9424012.
KEGGince:NCER_100836.

Organism-specific databases

EuPathDBiMicrosporidiaDB:NCER_100836.

Phylogenomic databases

InParanoidiC4V8K5.
KOiK03260.
OrthoDBiEOG7NW6K2.

Family and domain databases

Gene3Di1.25.40.180. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR016021. MIF4-like_typ_1/2/3.
IPR003890. MIF4G-like_typ-3.
[Graphical view]
PfamiPF02854. MIF4G. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genomic analyses of the microsporidian Nosema ceranae, an emergent pathogen of honey bees."
    Cornman R.S., Chen Y.P., Schatz M.C., Street C., Zhao Y., Desany B., Egholm M., Hutchison S., Pettis J.S., Lipkin W.I., Evans J.D.
    PLoS Pathog. 5:E1000466-E1000466(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BRL01.

Entry informationi

Entry nameiIF4G_NOSCE
AccessioniPrimary (citable) accession number: C4V8K5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: July 28, 2009
Last modified: January 7, 2015
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.