C4V8K5 (IF4G_NOSCE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable eukaryotic translation initiation factor 4 gamma homolog
Short name=eIF-4-gamma

Gene names

Name:	EIF4G
ORF Names:	NCER_100836

Organism

Nosema ceranae (strain BRL01) (Microsporidian parasite) [Complete proteome]

Taxonomic identifier

578460 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Microsporidia › Apansporoblastina › Nosematidae › Nosema › Nosema ceranae

Protein attributes

Sequence length	598 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome By similarity.
Subunit structure	Component of the eIF4F complex, which composition varies with external and internal environmental conditions By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the eukaryotic initiation factor 4G family. Contains 1 MIF4G domain.

Ontologies

Keywords
Biological process	Protein biosynthesis Translation regulation
Cellular component	Cytoplasm
Ligand	RNA-binding
Molecular function	Initiation factor
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	RNA metabolic process Inferred from electronic annotation. Source: InterPro regulation of translation Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: InterPro translation initiation factor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 598	598	Probable eukaryotic translation initiation factor 4 gamma homolog		PRO_0000388437
Regions
	Domain	209 – 434	226	MIF4G

Sequences

	Sequence		Length	Mass (Da)
	C4V8K5 [UniParc]. Last modified July 28, 2009. Version 1. Checksum: 0098C68E1D101797	FASTA	598	69,759
	10 20 30 40 50 60 MVNEVPTLKK KIIFKYFKPL LTFTKKEDPY ELRVKSAPPL NIIEERKEPK KFVLCKPDGT 70 80 90 100 110 120 PITLDDLSDI SDSEEEEDTK LDMKDSIKED VKDSIKEDVK DSSKEDVKDD VIEDVKGSIN 130 140 150 160 170 180 EEINSTCGTC SFINLKREKI LNELLEMYRV EESVPYSFVP TNVPQIMYSV GEILNCINKI 190 200 210 220 230 240 PFTLKLLKKD VNKIPVNYKE FKINKETIIE KATFELNKLT NTNIKRIITN LKNLNIETIQ 250 260 270 280 290 300 QAKYLGNLIV FKAINEPQYC NLYAMVVGAL KKDFKSKEEL GLHKKQTAFF GTVLTSAMKV 310 320 330 340 350 360 LEEKVEWADT KVLDKNLYKN AFEYERAFEE QETERYLRKK KTLGAVNLLC DLYNLDVITL 370 380 390 400 410 420 KHIQSRLNEF LNIENEEVVE VLGKFIEKIG EKMYLNDKSD YANMICSYLD ACKNKYSNRV 430 440 450 460 470 480 KFYIMDVLDK KKNWKKPVSK TENLFSSLIM EDEPALDTPY QYQEQVIANE EEEDSLELLK 490 500 510 520 530 540 TIDNIYQDLK DAYDEEDEIM IADNFKIASN TFGKISFFST YFSECITNSR KSKLLVPFVI 550 560 570 580 590 NFFNETNLNE SELFDIINKH KEKLNELKID FPLSQKIMSL YVINFVVDRL SKKIHMIN

References

[1]

"Genomic analyses of the microsporidian Nosema ceranae, an emergent pathogen of honey bees." Cornman R.S., Chen Y.P., Schatz M.C., Street C., Zhao Y., Desany B., Egholm M., Hutchison S., Pettis J.S., Lipkin W.I., Evans J.D. PLoS Pathog. 5:E1000466-E1000466(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: BRL01.

Cross-references

Sequence databases
EMBL GenBank DDBJ	ACOL01000057 Genomic DNA. Translation: EEQ82443.1.
RefSeq	XP_002996114.1. XM_002996068.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	9424012.
KEGG	nce:NCER_100836.
Organism-specific databases
EuPathDB	MicrosporidiaDB:NCER_100836.
Phylogenomic databases
KO	K03260.
Family and domain databases
Gene3D	1.25.40.180. 1 hit.
InterPro	IPR016024. ARM-type_fold. IPR016021. MIF4-like_typ_1/2/3. IPR003890. MIF4G-like_typ-3. [Graphical view]
Pfam	PF02854. MIF4G. 1 hit. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 1 hit.
ProtoNet	Search...

Entry information

Entry name

IF4G_NOSCE

Accession

Primary (citable) accession number: C4V8K5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 3, 2009
Last sequence update:	July 28, 2009
Last modified:	March 6, 2013
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program