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C4V819

- SYQ_NOSCE

UniProt

C4V819 - SYQ_NOSCE

Protein

Probable glutamine--tRNA ligase

Gene

NCER_100619

Organism
Nosema ceranae (strain BRL01) (Microsporidian parasite)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 25 (01 Oct 2014)
      Sequence version 1 (28 Jul 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei449 – 4491ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. glutamine-tRNA ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glutaminyl-tRNA aminoacylation Source: InterPro

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glutamine--tRNA ligase (EC:6.1.1.18)
    Alternative name(s):
    Glutaminyl-tRNA synthetase
    Short name:
    GlnRS
    Gene namesi
    ORF Names:NCER_100619
    OrganismiNosema ceranae (strain BRL01) (Microsporidian parasite)
    Taxonomic identifieri578460 [NCBI]
    Taxonomic lineageiEukaryotaFungiMicrosporidiaNosematidaeNosema
    ProteomesiUP000009082: Unassembled WGS sequence

    Organism-specific databases

    EuPathDBiMicrosporidiaDB:NCER_100619.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 695695Probable glutamine--tRNA ligasePRO_0000388383Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliC4V819.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi201 – 21111"HIGH" regionBy similarityAdd
    BLAST
    Motifi446 – 4505"KMSKS" regionBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    KOiK01886.
    OrthoDBiEOG7MD4ZK.

    Family and domain databases

    Gene3Di1.10.1160.10. 1 hit.
    2.40.240.10. 2 hits.
    3.40.50.620. 2 hits.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR004514. Gln-tRNA-synth.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
    IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
    IPR011035. Ribosomal_L25/Gln-tRNA_synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR10119. PTHR10119. 1 hit.
    PfamiPF00749. tRNA-synt_1c. 1 hit.
    PF03950. tRNA-synt_1c_C. 1 hit.
    [Graphical view]
    PRINTSiPR00987. TRNASYNTHGLU.
    SUPFAMiSSF50715. SSF50715. 1 hit.
    TIGRFAMsiTIGR00440. glnS. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C4V819-1 [UniParc]FASTAAdd to Basket

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    MFDVESLLKK LNVSEDKKEN ILQKEQLKKN LETLYTNFDT DNKLLFTLAC    50
    TAPKKIDILI FGILINENVI KNDATLRASM KFAIKNTDVT YEELKDFILK 100
    NTKSKEEVSE IINKACLSGK SKKEVYIILK NKLPFEDSKY LMDEVNKFEI 150
    DTSKSKKVKD WLEEGEVSML HKPGDNPQLN EKILKDHLER TGGKVVTRFP 200
    PEPNGILHIG HAKAINLDFG YAEKYNGICY LRFDDTNPRN EEDYYFESII 250
    EDVKWLGFEP YAITSSSKYF GDMCELAEKL ILKDKAYICE LSNEELKKRR 300
    RMLSEAFETD KDKSIEELGL ILSPYRNREI SENLKIFREM VEKKHKEGDY 350
    TLRFKMDIRS KNPMMFDLVG MRIIDCDHVV TKDKYNLYPS YEFALCVSDS 400
    LEDVTHSFCT REFFTRQESY KWLLDALEIY KPVQWEFSRL NISNTVLSKR 450
    KIVPLKKYGI ELDDPRLYTI KGMRRRGIPP QAINNFVKSL GITYAETIID 500
    NKKFESFIRD ELNKTTQRVM CVMDPLKIYI RNAKEQEISI PNSNQKIIFK 550
    PYIYIEKSDF KMEDDDKDFL RFTPNQSVGL YMFGAIKFIK FDNDMIIAEL 600
    TNETPKKFIH WVSCDSIKVT IRLYDPLFRS FNPEEGNYLD NINLDSLKTV 650
    VGYCDDRIKG CEVEDKFQFQ RVGYFCVDPD TTPENIVFNR IITLI 695
    Length:695
    Mass (Da):81,524
    Last modified:July 28, 2009 - v1
    Checksum:iB37230F4F506F579
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    ACOL01000036 Genomic DNA. Translation: EEQ82641.1.
    RefSeqiXP_002996312.1. XM_002996266.1.

    Genome annotation databases

    GeneIDi9422611.
    KEGGince:NCER_100619.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    ACOL01000036 Genomic DNA. Translation: EEQ82641.1 .
    RefSeqi XP_002996312.1. XM_002996266.1.

    3D structure databases

    ProteinModelPortali C4V819.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 9422611.
    KEGGi nce:NCER_100619.

    Organism-specific databases

    EuPathDBi MicrosporidiaDB:NCER_100619.

    Phylogenomic databases

    KOi K01886.
    OrthoDBi EOG7MD4ZK.

    Family and domain databases

    Gene3Di 1.10.1160.10. 1 hit.
    2.40.240.10. 2 hits.
    3.40.50.620. 2 hits.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR004514. Gln-tRNA-synth.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
    IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
    IPR011035. Ribosomal_L25/Gln-tRNA_synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR10119. PTHR10119. 1 hit.
    Pfami PF00749. tRNA-synt_1c. 1 hit.
    PF03950. tRNA-synt_1c_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00987. TRNASYNTHGLU.
    SUPFAMi SSF50715. SSF50715. 1 hit.
    TIGRFAMsi TIGR00440. glnS. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic analyses of the microsporidian Nosema ceranae, an emergent pathogen of honey bees."
      Cornman R.S., Chen Y.P., Schatz M.C., Street C., Zhao Y., Desany B., Egholm M., Hutchison S., Pettis J.S., Lipkin W.I., Evans J.D.
      PLoS Pathog. 5:E1000466-E1000466(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BRL01.

    Entry informationi

    Entry nameiSYQ_NOSCE
    AccessioniPrimary (citable) accession number: C4V819
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 3, 2009
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 25 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3