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Protein

Probable glutamine--tRNA ligase

Gene

NCER_100619

Organism
Nosema ceranae (strain BRL01) (Microsporidian parasite)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei449 – 4491ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glutamine-tRNA ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. glutaminyl-tRNA aminoacylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glutamine--tRNA ligase (EC:6.1.1.18)
Alternative name(s):
Glutaminyl-tRNA synthetase
Short name:
GlnRS
Gene namesi
ORF Names:NCER_100619
OrganismiNosema ceranae (strain BRL01) (Microsporidian parasite)
Taxonomic identifieri578460 [NCBI]
Taxonomic lineageiEukaryotaFungiMicrosporidiaNosematidaeNosema
ProteomesiUP000009082 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiMicrosporidiaDB:NCER_100619.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 695695Probable glutamine--tRNA ligasePRO_0000388383Add
BLAST

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi201 – 21111"HIGH" regionBy similarityAdd
BLAST
Motifi446 – 4505"KMSKS" regionBy similarity

Sequence similaritiesi

Phylogenomic databases

InParanoidiC4V819.
KOiK01886.
OrthoDBiEOG7MD4ZK.

Family and domain databases

Gene3Di1.10.1160.10. 1 hit.
2.40.240.10. 2 hits.
3.40.50.620. 2 hits.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR004514. Gln-tRNA-synth.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR10119. PTHR10119. 1 hit.
PfamiPF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
[Graphical view]
PRINTSiPR00987. TRNASYNTHGLU.
SUPFAMiSSF50715. SSF50715. 1 hit.
TIGRFAMsiTIGR00440. glnS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C4V819-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFDVESLLKK LNVSEDKKEN ILQKEQLKKN LETLYTNFDT DNKLLFTLAC
60 70 80 90 100
TAPKKIDILI FGILINENVI KNDATLRASM KFAIKNTDVT YEELKDFILK
110 120 130 140 150
NTKSKEEVSE IINKACLSGK SKKEVYIILK NKLPFEDSKY LMDEVNKFEI
160 170 180 190 200
DTSKSKKVKD WLEEGEVSML HKPGDNPQLN EKILKDHLER TGGKVVTRFP
210 220 230 240 250
PEPNGILHIG HAKAINLDFG YAEKYNGICY LRFDDTNPRN EEDYYFESII
260 270 280 290 300
EDVKWLGFEP YAITSSSKYF GDMCELAEKL ILKDKAYICE LSNEELKKRR
310 320 330 340 350
RMLSEAFETD KDKSIEELGL ILSPYRNREI SENLKIFREM VEKKHKEGDY
360 370 380 390 400
TLRFKMDIRS KNPMMFDLVG MRIIDCDHVV TKDKYNLYPS YEFALCVSDS
410 420 430 440 450
LEDVTHSFCT REFFTRQESY KWLLDALEIY KPVQWEFSRL NISNTVLSKR
460 470 480 490 500
KIVPLKKYGI ELDDPRLYTI KGMRRRGIPP QAINNFVKSL GITYAETIID
510 520 530 540 550
NKKFESFIRD ELNKTTQRVM CVMDPLKIYI RNAKEQEISI PNSNQKIIFK
560 570 580 590 600
PYIYIEKSDF KMEDDDKDFL RFTPNQSVGL YMFGAIKFIK FDNDMIIAEL
610 620 630 640 650
TNETPKKFIH WVSCDSIKVT IRLYDPLFRS FNPEEGNYLD NINLDSLKTV
660 670 680 690
VGYCDDRIKG CEVEDKFQFQ RVGYFCVDPD TTPENIVFNR IITLI
Length:695
Mass (Da):81,524
Last modified:July 27, 2009 - v1
Checksum:iB37230F4F506F579
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACOL01000036 Genomic DNA. Translation: EEQ82641.1.
RefSeqiXP_002996312.1. XM_002996266.1.

Genome annotation databases

GeneIDi9422611.
KEGGince:NCER_100619.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACOL01000036 Genomic DNA. Translation: EEQ82641.1.
RefSeqiXP_002996312.1. XM_002996266.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi9422611.
KEGGince:NCER_100619.

Organism-specific databases

EuPathDBiMicrosporidiaDB:NCER_100619.

Phylogenomic databases

InParanoidiC4V819.
KOiK01886.
OrthoDBiEOG7MD4ZK.

Family and domain databases

Gene3Di1.10.1160.10. 1 hit.
2.40.240.10. 2 hits.
3.40.50.620. 2 hits.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR004514. Gln-tRNA-synth.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR10119. PTHR10119. 1 hit.
PfamiPF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
[Graphical view]
PRINTSiPR00987. TRNASYNTHGLU.
SUPFAMiSSF50715. SSF50715. 1 hit.
TIGRFAMsiTIGR00440. glnS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genomic analyses of the microsporidian Nosema ceranae, an emergent pathogen of honey bees."
    Cornman R.S., Chen Y.P., Schatz M.C., Street C., Zhao Y., Desany B., Egholm M., Hutchison S., Pettis J.S., Lipkin W.I., Evans J.D.
    PLoS Pathog. 5:E1000466-E1000466(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BRL01.

Entry informationi

Entry nameiSYQ_NOSCE
AccessioniPrimary (citable) accession number: C4V819
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2009
Last sequence update: July 27, 2009
Last modified: March 31, 2015
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.