ID   C4V7S3_VAIC1            Unreviewed;       592 AA.
AC   C4V7S3;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   27-MAR-2024, entry version 66.
DE   RecName: Full=DNA ligase {ECO:0000256|RuleBase:RU000617};
DE            EC=6.5.1.1 {ECO:0000256|RuleBase:RU000617};
GN   ORFNames=NCER_100511 {ECO:0000313|EMBL:EEQ82740.1};
OS   Vairimorpha ceranae (strain BRL01) (Microsporidian parasite) (Nosema
OS   ceranae).
OC   Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Nosematidae;
OC   Vairimorpha.
OX   NCBI_TaxID=578460 {ECO:0000313|Proteomes:UP000009082};
RN   [1] {ECO:0000313|Proteomes:UP000009082}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BRL01 {ECO:0000313|Proteomes:UP000009082};
RX   PubMed=19503607; DOI=10.1371/journal.ppat.1000466;
RA   Cornman R.S., Chen Y.P., Schatz M.C., Street C., Zhao Y., Desany B.,
RA   Egholm M., Hutchison S., Pettis J.S., Lipkin W.I., Evans J.D.;
RT   "Genomic analyses of the microsporidian Nosema ceranae, an emergent
RT   pathogen of honey bees.";
RL   PLoS Pathog. 5:E1000466-E1000466(2009).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-
CC         (deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP +
CC         diphosphate.; EC=6.5.1.1; Evidence={ECO:0000256|ARBA:ARBA00034003,
CC         ECO:0000256|RuleBase:RU000617};
CC   -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC       {ECO:0000256|ARBA:ARBA00007572, ECO:0000256|RuleBase:RU004196}.
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DR   EMBL; ACOL01000027; EEQ82740.1; -; Genomic_DNA.
DR   RefSeq; XP_002996411.1; XM_002996365.1.
DR   AlphaFoldDB; C4V7S3; -.
DR   STRING; 578460.C4V7S3; -.
DR   KEGG; nce:NCER_100511; -.
DR   VEuPathDB; MicrosporidiaDB:NCER_100511; -.
DR   HOGENOM; CLU_005138_4_1_1; -.
DR   InParanoid; C4V7S3; -.
DR   OMA; DERSHAW; -.
DR   OrthoDB; 961at2759; -.
DR   Proteomes; UP000009082; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd07900; Adenylation_DNA_ligase_I_Euk; 1.
DR   CDD; cd07969; OBF_DNA_ligase_I; 1.
DR   Gene3D; 1.10.3260.10; DNA ligase, ATP-dependent, N-terminal domain; 1.
DR   Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR   InterPro; IPR000977; DNA_ligase_ATP-dep.
DR   InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR   InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR   InterPro; IPR036599; DNA_ligase_N_sf.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   NCBIfam; TIGR00574; dnl1; 1.
DR   PANTHER; PTHR45674; DNA LIGASE 1/3 FAMILY MEMBER; 1.
DR   PANTHER; PTHR45674:SF9; DNA LIGASE 3; 1.
DR   Pfam; PF04679; DNA_ligase_A_C; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF04675; DNA_ligase_A_N; 1.
DR   SUPFAM; SSF117018; ATP-dependent DNA ligase DNA-binding domain; 1.
DR   SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR   PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR   PROSITE; PS00333; DNA_LIGASE_A2; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU000617};
KW   DNA damage {ECO:0000256|RuleBase:RU000617};
KW   DNA recombination {ECO:0000256|RuleBase:RU000617};
KW   DNA repair {ECO:0000256|RuleBase:RU000617};
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU000617};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU000617};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009082}.
FT   DOMAIN          333..469
FT                   /note="ATP-dependent DNA ligase family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50160"
SQ   SEQUENCE   592 AA;  68957 MW;  F712EDDBEDD29EB3 CRC64;
     MENEIKPNSF LYFSKIMEKI SQRSGRIEIQ DMLTEYFRDV ISINKNDLIY VIYLCTHTIY
     PEYKNQQLNL GEKILFDVLK ECTSKDITIL KKEYTKIGDF GTIGMTYRTR QLFISKKTLS
     AKDVVYALRE IAEISGIKSR IYKIRKMLDL ISSCTPIEIK FLFRLFEENL KVKFALKTVL
     AAFAKLYDSA YIDKIKEAYN RRPDIEQLVI EILTNGISTV DTNFNIEPGI PLKPMLAQPT
     KNISTAFKRV ENKKFTCENK YDGERIQIHR HNNQMTLYSR NLENTTDKYF DIIIKSNTDK
     DFVIDGEVVA YDPEQKKILT FQKLSTRKRK DFSKKETVNV CVFVFDILYF DGLELINKSL
     EDRRAILHKE FTEVEGKFFF SEFKDCENIE EVDEFFRQSI NSQYEGIMIK LLGDGSNYIP
     SQRCNSWIKL KKDYIESGSD SFDLVVVGAY YGKGKRTGWY GGFLLASYNE NDEMFETVCK
     IGTGFDDSLL SKLYEEVNNY VVSIPSRVKY KEQTKPDVWI TPKFVWEIKA AAVSASPIYC
     CGIDIEEKGF SLRFPRFLNE REDKDVTDAT TSLQIVMNYK EYEGESKVLD DI
//