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C4V7S3

- C4V7S3_NOSCE

UniProt

C4V7S3 - C4V7S3_NOSCE

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Protein

DNA ligase

Gene

NCER_100511

Organism
Nosema ceranae (strain BRL01) (Microsporidian parasite)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA biosynthetic process Source: InterPro
  2. DNA ligation involved in DNA repair Source: InterPro
  3. DNA recombination Source: UniProtKB-KW
  4. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
ORF Names:NCER_100511Imported
OrganismiNosema ceranae (strain BRL01) (Microsporidian parasite)Imported
Taxonomic identifieri578460 [NCBI]
Taxonomic lineageiEukaryotaFungiMicrosporidiaNosematidaeNosema
ProteomesiUP000009082: Unassembled WGS sequence

Organism-specific databases

EuPathDBiMicrosporidiaDB:NCER_100511.

Structurei

3D structure databases

ProteinModelPortaliC4V7S3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

InParanoidiC4V7S3.
KOiK10747.
OrthoDBiEOG7TXKRG.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C4V7S3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MENEIKPNSF LYFSKIMEKI SQRSGRIEIQ DMLTEYFRDV ISINKNDLIY
60 70 80 90 100
VIYLCTHTIY PEYKNQQLNL GEKILFDVLK ECTSKDITIL KKEYTKIGDF
110 120 130 140 150
GTIGMTYRTR QLFISKKTLS AKDVVYALRE IAEISGIKSR IYKIRKMLDL
160 170 180 190 200
ISSCTPIEIK FLFRLFEENL KVKFALKTVL AAFAKLYDSA YIDKIKEAYN
210 220 230 240 250
RRPDIEQLVI EILTNGISTV DTNFNIEPGI PLKPMLAQPT KNISTAFKRV
260 270 280 290 300
ENKKFTCENK YDGERIQIHR HNNQMTLYSR NLENTTDKYF DIIIKSNTDK
310 320 330 340 350
DFVIDGEVVA YDPEQKKILT FQKLSTRKRK DFSKKETVNV CVFVFDILYF
360 370 380 390 400
DGLELINKSL EDRRAILHKE FTEVEGKFFF SEFKDCENIE EVDEFFRQSI
410 420 430 440 450
NSQYEGIMIK LLGDGSNYIP SQRCNSWIKL KKDYIESGSD SFDLVVVGAY
460 470 480 490 500
YGKGKRTGWY GGFLLASYNE NDEMFETVCK IGTGFDDSLL SKLYEEVNNY
510 520 530 540 550
VVSIPSRVKY KEQTKPDVWI TPKFVWEIKA AAVSASPIYC CGIDIEEKGF
560 570 580 590
SLRFPRFLNE REDKDVTDAT TSLQIVMNYK EYEGESKVLD DI
Length:592
Mass (Da):68,957
Last modified:July 28, 2009 - v1
Checksum:iF712EDDBEDD29EB3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACOL01000027 Genomic DNA. Translation: EEQ82740.1.
RefSeqiXP_002996411.1. XM_002996365.1.

Genome annotation databases

GeneIDi9422802.
KEGGince:NCER_100511.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACOL01000027 Genomic DNA. Translation: EEQ82740.1 .
RefSeqi XP_002996411.1. XM_002996365.1.

3D structure databases

ProteinModelPortali C4V7S3.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 9422802.
KEGGi nce:NCER_100511.

Organism-specific databases

EuPathDBi MicrosporidiaDB:NCER_100511.

Phylogenomic databases

InParanoidi C4V7S3.
KOi K10747.
OrthoDBi EOG7TXKRG.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProi IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genomic analyses of the microsporidian Nosema ceranae, an emergent pathogen of honey bees."
    Cornman R.S., Chen Y.P., Schatz M.C., Street C., Zhao Y., Desany B., Egholm M., Hutchison S., Pettis J.S., Lipkin W.I., Evans J.D.
    PLoS Pathog. 5:E1000466-E1000466(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BRL01Imported.

Entry informationi

Entry nameiC4V7S3_NOSCE
AccessioniPrimary (citable) accession number: C4V7S3
Entry historyi
Integrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: October 29, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3