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Protein

DNA ligase

Gene

NCER_100511

Organism
Nosema ceranae (strain BRL01) (Microsporidian parasite)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotation
Biological processDNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
ORF Names:NCER_100511Imported
OrganismiNosema ceranae (strain BRL01) (Microsporidian parasite)Imported
Taxonomic identifieri578460 [NCBI]
Taxonomic lineageiEukaryotaFungiFungi incertae sedisMicrosporidiaNosematidaeNosema
Proteomesi
  • UP000009082 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiMicrosporidiaDB:NCER_100511

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Structurei

3D structure databases

ProteinModelPortaliC4V7S3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini333 – 469DNA_LIGASE_A3InterPro annotationAdd BLAST137

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

InParanoidiC4V7S3
KOiK10747
OrthoDBiEOG092C0FHN

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
InterProiView protein in InterPro
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00697 DNA_LIGASE_A1, 1 hit
PS00333 DNA_LIGASE_A2, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

C4V7S3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENEIKPNSF LYFSKIMEKI SQRSGRIEIQ DMLTEYFRDV ISINKNDLIY
60 70 80 90 100
VIYLCTHTIY PEYKNQQLNL GEKILFDVLK ECTSKDITIL KKEYTKIGDF
110 120 130 140 150
GTIGMTYRTR QLFISKKTLS AKDVVYALRE IAEISGIKSR IYKIRKMLDL
160 170 180 190 200
ISSCTPIEIK FLFRLFEENL KVKFALKTVL AAFAKLYDSA YIDKIKEAYN
210 220 230 240 250
RRPDIEQLVI EILTNGISTV DTNFNIEPGI PLKPMLAQPT KNISTAFKRV
260 270 280 290 300
ENKKFTCENK YDGERIQIHR HNNQMTLYSR NLENTTDKYF DIIIKSNTDK
310 320 330 340 350
DFVIDGEVVA YDPEQKKILT FQKLSTRKRK DFSKKETVNV CVFVFDILYF
360 370 380 390 400
DGLELINKSL EDRRAILHKE FTEVEGKFFF SEFKDCENIE EVDEFFRQSI
410 420 430 440 450
NSQYEGIMIK LLGDGSNYIP SQRCNSWIKL KKDYIESGSD SFDLVVVGAY
460 470 480 490 500
YGKGKRTGWY GGFLLASYNE NDEMFETVCK IGTGFDDSLL SKLYEEVNNY
510 520 530 540 550
VVSIPSRVKY KEQTKPDVWI TPKFVWEIKA AAVSASPIYC CGIDIEEKGF
560 570 580 590
SLRFPRFLNE REDKDVTDAT TSLQIVMNYK EYEGESKVLD DI
Length:592
Mass (Da):68,957
Last modified:July 28, 2009 - v1
Checksum:iF712EDDBEDD29EB3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACOL01000027 Genomic DNA Translation: EEQ82740.1
RefSeqiXP_002996411.1, XM_002996365.1

Genome annotation databases

EnsemblFungiiEEQ82740; EEQ82740; NCER_100511
KEGGince:NCER_100511

Similar proteinsi

Entry informationi

Entry nameiC4V7S3_NOSCE
AccessioniPrimary (citable) accession number: C4V7S3
Entry historyiIntegrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: May 23, 2018
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health