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Protein

DNA ligase

Gene

PAS_chr3_1112

Organism
Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported
Biological processDNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:PAS_chr3_1112Imported
OrganismiKomagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris)Imported
Taxonomic identifieri644223 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesPhaffomycetaceaeKomagataella
Proteomesi
  • UP000000314 Componenti: Chromosome 3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Interactioni

Protein-protein interaction databases

STRINGi644223.XP_002493358.1

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini492 – 629DNA_LIGASE_A3InterPro annotationAdd BLAST138

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0967 Eukaryota
COG1793 LUCA
HOGENOMiHOG000036006
InParanoidiC4R6J3
KOiK10747
OMAiRHAERNT
OrthoDBiEOG092C0FHN

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
InterProiView protein in InterPro
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00697 DNA_LIGASE_A1, 1 hit
PS00333 DNA_LIGASE_A2, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

C4R6J3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHCGPLLFP NLDLSRNLSK RLFLCYISYY NCFIMSGQQS LNRFFSARKP
60 70 80 90 100
EIVNSTSKKL ISQKRTTETD YSPLKRTKNS TMLECGDLNS PHLAKVGYPD
110 120 130 140 150
LEKDTVDSNI LVEAESLLKL ESKYHSDSPD LPQSQEIFYS SLTNIFEKLE
160 170 180 190 200
QEPARLKNLA IASEFFLQIL RSNHKRTLVE VIYLMINRLG PDYELDLELG
210 220 230 240 250
LGETLLVKAI AEGTGRTPQR IRSELHKLGD IGLVAQNSRS RQPTMFKSKP
260 270 280 290 300
LTIHSVFENL TKIAKSSGNA SQARKIGLIN QMLTTCEGSE AKFLMRSLEG
310 320 330 340 350
KLRINFGEKS VLVALSKAFS EYEHELSSKK GHVSPQELVD AEEAIKKAFS
360 370 380 390 400
QIPNYEIIVD EALKYGISNL ATHCTLKPGI PLKPMLAKPT KSITEVLDHF
410 420 430 440 450
HGQEFTCEYK YDGERAQLHV QEDGTVKIYS RNSEDMSQRY PDLIDVVSQI
460 470 480 490 500
KTQCNGVITL ILDCECVAWD GEKGKILPFQ VLSTRKRKDV NAKDIKVQVC
510 520 530 540 550
LFAFDILFLN GKSLLELPLK ERRKILHENV KPIEGKFQFA EAMDADNVAE
560 570 580 590 600
IQHFLDQSVK DSCEGLMVKM LDGDKSHYEP SKRSVNWLKL KKDYLEGVGD
610 620 630 640 650
SLDLAVVGGY IGKGKRTGWY GGFLLACYNE DSGEYETCCK IGTGFSEEML
660 670 680 690 700
QTLSGTLKPT VIQQPKPFYV YDASPDVWFE PTLVFEVLTA DLSLSPVYKA
710 720 730 740
GINFFGKGVS LRFPRFIRVR DDKSPEQATS SDQIVELYQK QAHV
Length:744
Mass (Da):83,945
Last modified:July 7, 2009 - v1
Checksum:iDDA84A811C6FBD3B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN392321 Genomic DNA Translation: CAY71179.1
RefSeqiXP_002493358.1, XM_002493313.1

Genome annotation databases

EnsemblFungiiCAY71179; CAY71179; PAS_chr3_1112
GeneIDi8200069
KEGGippa:PAS_chr3_1112

Similar proteinsi

Entry informationi

Entry nameiC4R6J3_KOMPG
AccessioniPrimary (citable) accession number: C4R6J3
Entry historyiIntegrated into UniProtKB/TrEMBL: July 7, 2009
Last sequence update: July 7, 2009
Last modified: March 28, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health