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Protein

DNA ligase

Gene

PAS_chr3_1112

Organism
Komagataella pastoris (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-EC

GO - Biological processi

  1. base-excision repair Source: EnsemblFungi
  2. DNA biosynthetic process Source: InterPro
  3. DNA ligation involved in DNA repair Source: InterPro
  4. DNA recombination Source: UniProtKB-KW
  5. maintenance of DNA trinucleotide repeats Source: EnsemblFungi
  6. nucleotide-excision repair Source: EnsemblFungi
  7. Okazaki fragment processing involved in mitotic DNA replication Source: EnsemblFungi
  8. telomere maintenance Source: EnsemblFungi
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:PAS_chr3_1112Imported
OrganismiKomagataella pastoris (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris)Imported
Taxonomic identifieri644223 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesPhaffomycetaceaeKomagataella
ProteomesiUP000000314 Componenti: Chromosome 3

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: EnsemblFungi
  2. nucleus Source: EnsemblFungi
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi644223.PAS_chr3_1112.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000036006.
InParanoidiC4R6J3.
KOiK10747.
OrthoDBiEOG7TXKRG.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C4R6J3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHCGPLLFP NLDLSRNLSK RLFLCYISYY NCFIMSGQQS LNRFFSARKP
60 70 80 90 100
EIVNSTSKKL ISQKRTTETD YSPLKRTKNS TMLECGDLNS PHLAKVGYPD
110 120 130 140 150
LEKDTVDSNI LVEAESLLKL ESKYHSDSPD LPQSQEIFYS SLTNIFEKLE
160 170 180 190 200
QEPARLKNLA IASEFFLQIL RSNHKRTLVE VIYLMINRLG PDYELDLELG
210 220 230 240 250
LGETLLVKAI AEGTGRTPQR IRSELHKLGD IGLVAQNSRS RQPTMFKSKP
260 270 280 290 300
LTIHSVFENL TKIAKSSGNA SQARKIGLIN QMLTTCEGSE AKFLMRSLEG
310 320 330 340 350
KLRINFGEKS VLVALSKAFS EYEHELSSKK GHVSPQELVD AEEAIKKAFS
360 370 380 390 400
QIPNYEIIVD EALKYGISNL ATHCTLKPGI PLKPMLAKPT KSITEVLDHF
410 420 430 440 450
HGQEFTCEYK YDGERAQLHV QEDGTVKIYS RNSEDMSQRY PDLIDVVSQI
460 470 480 490 500
KTQCNGVITL ILDCECVAWD GEKGKILPFQ VLSTRKRKDV NAKDIKVQVC
510 520 530 540 550
LFAFDILFLN GKSLLELPLK ERRKILHENV KPIEGKFQFA EAMDADNVAE
560 570 580 590 600
IQHFLDQSVK DSCEGLMVKM LDGDKSHYEP SKRSVNWLKL KKDYLEGVGD
610 620 630 640 650
SLDLAVVGGY IGKGKRTGWY GGFLLACYNE DSGEYETCCK IGTGFSEEML
660 670 680 690 700
QTLSGTLKPT VIQQPKPFYV YDASPDVWFE PTLVFEVLTA DLSLSPVYKA
710 720 730 740
GINFFGKGVS LRFPRFIRVR DDKSPEQATS SDQIVELYQK QAHV
Length:744
Mass (Da):83,945
Last modified:July 6, 2009 - v1
Checksum:iDDA84A811C6FBD3B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN392321 Genomic DNA. Translation: CAY71179.1.
RefSeqiXP_002493358.1. XM_002493313.1.

Genome annotation databases

EnsemblFungiiCAY71179; CAY71179; PAS_chr3_1112.
GeneIDi8200069.
KEGGippa:PAS_chr3_1112.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN392321 Genomic DNA. Translation: CAY71179.1.
RefSeqiXP_002493358.1. XM_002493313.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi644223.PAS_chr3_1112.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAY71179; CAY71179; PAS_chr3_1112.
GeneIDi8200069.
KEGGippa:PAS_chr3_1112.

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000036006.
InParanoidiC4R6J3.
KOiK10747.
OrthoDBiEOG7TXKRG.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GS115 / ATCC 20864Imported.

Entry informationi

Entry nameiC4R6J3_PICPG
AccessioniPrimary (citable) accession number: C4R6J3
Entry historyi
Integrated into UniProtKB/TrEMBL: July 6, 2009
Last sequence update: July 6, 2009
Last modified: March 31, 2015
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.