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Protein

DNA-directed RNA polymerase subunit

Gene

PAS_chr3_0568

Organism
Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.UniRule annotation

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi67Zinc 1Combined sources1
Metal bindingi67Zinc 2Combined sources1
Metal bindingi70Zinc 1Combined sources1
Metal bindingi70Zinc 2Combined sources1
Metal bindingi70Zinc 3Combined sources1
Metal bindingi77Zinc 3Combined sources1
Metal bindingi80Zinc 1; via tele nitrogenCombined sources1
Metal bindingi80Zinc 3; via tele nitrogenCombined sources1
Metal bindingi107Zinc 4Combined sources1
Metal bindingi107Zinc 5Combined sources1
Metal bindingi110Zinc 4Combined sources1
Metal bindingi148Zinc 4Combined sources1
Metal bindingi167Zinc 5; via carbonyl oxygenCombined sources1
Metal bindingi168Zinc 5Combined sources1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferaseUniRule annotation, Transferase
Biological processTranscription
LigandMetal-bindingCombined sources, ZincCombined sources

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase subunitUniRule annotation (EC:2.7.7.6UniRule annotation)
Gene namesi
Ordered Locus Names:PAS_chr3_0568Imported
OrganismiKomagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris)Imported
Taxonomic identifieri644223 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesPhaffomycetaceaeKomagataella
Proteomesi
  • UP000000314 Componenti: Chromosome 3

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

DNA-directed RNA polymeraseUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi644223.XP_002492795.1.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5X4ZX-ray7.80A/M1-1743[»]
5X50X-ray4.29A1-1743[»]
5X51X-ray7.00A/M1-1743[»]
SMRiC4R4Y0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini233 – 536RPOLA_NInterPro annotationAdd BLAST304

Sequence similaritiesi

Belongs to the RNA polymerase beta' chain family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0260. Eukaryota.
COG0086. LUCA.
HOGENOMiHOG000222975.
InParanoidiC4R4Y0.
KOiK03006.
OMAiMPDFDPT.
OrthoDBiEOG092C01XQ.

Family and domain databases

InterProiView protein in InterPro
IPR000722. RNA_pol_asu.
IPR000684. RNA_pol_II_repeat_euk.
IPR006592. RNA_pol_N.
IPR007080. RNA_pol_Rpb1_1.
IPR007066. RNA_pol_Rpb1_3.
IPR007083. RNA_pol_Rpb1_4.
IPR007081. RNA_pol_Rpb1_5.
IPR007075. RNA_pol_Rpb1_6.
IPR007073. RNA_pol_Rpb1_7.
PfamiView protein in Pfam
PF04997. RNA_pol_Rpb1_1. 1 hit.
PF00623. RNA_pol_Rpb1_2. 1 hit.
PF04983. RNA_pol_Rpb1_3. 1 hit.
PF05000. RNA_pol_Rpb1_4. 1 hit.
PF04998. RNA_pol_Rpb1_5. 1 hit.
PF04992. RNA_pol_Rpb1_6. 1 hit.
PF04990. RNA_pol_Rpb1_7. 1 hit.
PF05001. RNA_pol_Rpb1_R. 15 hits.
SMARTiView protein in SMART
SM00663. RPOLA_N. 1 hit.
PROSITEiView protein in PROSITE
PS00115. RNA_POL_II_REPEAT. 3 hits.

Sequencei

Sequence statusi: Complete.

C4R4Y0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQFPYSSAP LRSVKEVQFG LLSPEEIRAI SVVKIEYPEI MDESRQRPRE
60 70 80 90 100
GGLNDPKLGS IDRNFKCQTC GEGMAECPGH FGHMELAKPV FHIGFIPKIK
110 120 130 140 150
KVCECICMNC GKLLLDETNP TMAQAIRIRD PKKRFNAVWQ LCKTKMVCEA
160 170 180 190 200
DAPVDEYSEQ KVVSRGGCGN TQPVVRKDGM KLWGTWKKSG FSDRDAQPER
210 220 230 240 250
KLLTPGEILN VFKHISPEDC FRLGFNEDYA RPEWMIITVL PVPPPQVRPS
260 270 280 290 300
IAMDETTQGQ DDLTHKLSDI LKANINVQKL EMDGSPQHII NEVEQLLQFH
310 320 330 340 350
VATYMDNDIA GQPQALQKSG RPVKAIRARL KGKEGRLRGN LMGKRVDFSA
360 370 380 390 400
RTVISGDPNL ELDQVGVPIS IAKTLSYPET VTQYNIHRLT EYVRNGPNEH
410 420 430 440 450
PGAKYVIRDN GDRIDLRYHK RAGDIVLQYG WKVERHLMDD DPVLFNRQPS
460 470 480 490 500
LHKMSMMAHR VKVMPYSTFR LNLSVTSPYN ADFDGDEMNL HVPQSEETRA
510 520 530 540 550
ELSQLCAVPL QIVSPQSNKP VMGIVQDTLC GVRKMTLRDT FIEYEQVMNM
560 570 580 590 600
LFWVPSWDGV VPQPAILKPK PLWTGKQLLS IAIPSGIHLQ RTDGGNSLLS
610 620 630 640 650
PKDNGMLIVD GKVMFGVVDK KTVGSGGGGL IHTVMREKGP KICAELFGNI
660 670 680 690 700
QKVVNYWLLH NGFSIGIGDA IADASTMKEI THAISSAKEQ VQEIIYKAQH
710 720 730 740 750
NELELKPGMT LRESFEGEVS RTLNDARDSA GRSAEMNLKD LNNVKQMVSA
760 770 780 790 800
GSKGSFINIA QMSACVGQQM VEGKRIAFGF ADRSLPHFTK DDFSPESKGF
810 820 830 840 850
VENSYLRGLT PQEFFFHAMA GREGLIDTAV KTAETGYIQR RLVKALEDIM
860 870 880 890 900
VHYDGTTRNS LGDIIQFLYG EDGLDGTQVE RQTIDTIPGS DKAFHKRYYV
910 920 930 940 950
DLMDEKNSIK PDVIEYAADI LGDVELQKEL NSEYEQLVSD RKFLREIVFV
960 970 980 990 1000
NGDHNWPLPV NLRRIIQNAQ QIFHLDRAKA SDLTIPEIIH GVRDLCKKLF
1010 1020 1030 1040 1050
VLRGENELIK EAQQNATSLF QCLVRARLAT RRILEEFRLN RDAFEWVLGT
1060 1070 1080 1090 1100
IEAQFQRSLV HPGEMVGVIA AQSIGEPATQ MTLNTFHYAG VSSKNVTLGV
1110 1120 1130 1140 1150
PRLKEILNVA KNIKTPALTV YLDREIALDI EKAKVIQSSI EYTTLKNVTS
1160 1170 1180 1190 1200
ATEIYYDPDP TSTVIEEDFD TVEAYFSIPD EKVEETIDKQ SPWLLRLELD
1210 1220 1230 1240 1250
RARMLDKQLT MNQVADKISE VFSDDLFVMW SEDNADKLII RCRVIRDPKA
1260 1270 1280 1290 1300
MDEELEAEED QMLKRIEAHM LDLIALRGIP GISKVYMVKH KVSVPDESGE
1310 1320 1330 1340 1350
YKNEELWALE TDGINLAEVM AVPGVDSSRT YSNSFVEILS VLGIEATRSS
1360 1370 1380 1390 1400
LYKEILNVIA FDGSYVNYRH MALLVDVMTS RGYLMAITRH GINRADTGAL
1410 1420 1430 1440 1450
MRCSFEETVE ILFEAGAAAE LDDCRGVSEN VMLGQLAPMG TGAFDVMIDE
1460 1470 1480 1490 1500
KLLTSLPADY APTMPLFKGK ATQGSATPYD NNAQYDDEFN HDDVADVMFS
1510 1520 1530 1540 1550
PMAETGSGDD RSGGLTEYAG IQSPYQPTSP GLSATSPGFA PTSPGFAPTS
1560 1570 1580 1590 1600
PRYSPTSPGY SPTSPSYSPT SPSYSPTSPS YSPTSPSYSP TSPSYSPTSP
1610 1620 1630 1640 1650
SYSPTSPSYS PTSPSYSPTS PSYSPTSPQY SPTSPQYSPT SPQYSPTSPQ
1660 1670 1680 1690 1700
YSPTSPQYSP TSPQYSPTSP QYSPTSPQYS PTSPQYSPTS PQYSPTSPQY
1710 1720 1730 1740
SPTSPQYSPT SPQYSPTSPQ YSPASPQYSP SRHSPNGESK EGE
Length:1,743
Mass (Da):193,897
Last modified:July 7, 2009 - v1
Checksum:iC61FD1B6AFF25C54
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN392321 Genomic DNA. Translation: CAY70616.1.
RefSeqiXP_002492795.1. XM_002492750.1.

Genome annotation databases

EnsemblFungiiCAY70616; CAY70616; PAS_chr3_0568.
GeneIDi8199932.
KEGGippa:PAS_chr3_0568.

Similar proteinsi

Entry informationi

Entry nameiC4R4Y0_KOMPG
AccessioniPrimary (citable) accession number: C4R4Y0
Entry historyiIntegrated into UniProtKB/TrEMBL: July 7, 2009
Last sequence update: July 7, 2009
Last modified: August 30, 2017
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported