ID   C4R4P4_KOMPG            Unreviewed;       510 AA.
AC   C4R4P4;
DT   07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   07-JUL-2009, sequence version 1.
DT   27-MAR-2024, entry version 72.
DE   RecName: Full=alanine transaminase {ECO:0000256|ARBA:ARBA00026106};
DE            EC=2.6.1.2 {ECO:0000256|ARBA:ARBA00026106};
GN   OrderedLocusNames=PAS_chr3_0482 {ECO:0000313|EMBL:CAY70530.1};
OS   Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Phaffomycetaceae; Komagataella.
OX   NCBI_TaxID=644223 {ECO:0000313|EMBL:CAY70530.1, ECO:0000313|Proteomes:UP000000314};
RN   [1] {ECO:0000313|EMBL:CAY70530.1, ECO:0000313|Proteomes:UP000000314}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GS115 / ATCC 20864 {ECO:0000313|Proteomes:UP000000314};
RX   PubMed=19465926; DOI=10.1038/nbt.1544;
RA   De Schutter K., Lin Y.C., Tiels P., Van Hecke A., Glinka S.,
RA   Weber-Lehmann J., Rouze P., Van de Peer Y., Callewaert N.;
RT   "Genome sequence of the recombinant protein production host Pichia
RT   pastoris.";
RL   Nat. Biotechnol. 27:561-566(2009).
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933};
CC   -!- PATHWAY: Amino-acid degradation; L-alanine degradation via transaminase
CC       pathway; pyruvate from L-alanine: step 1/1.
CC       {ECO:0000256|ARBA:ARBA00025708}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC   -!- SIMILARITY: Belongs to the class-I pyridoxal-phosphate-dependent
CC       aminotransferase family. Alanine aminotransferase subfamily.
CC       {ECO:0000256|ARBA:ARBA00025785}.
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DR   EMBL; FN392321; CAY70530.1; -; Genomic_DNA.
DR   RefSeq; XP_002492709.1; XM_002492664.1.
DR   AlphaFoldDB; C4R4P4; -.
DR   SMR; C4R4P4; -.
DR   STRING; 644223.C4R4P4; -.
DR   EnsemblFungi; CAY70530; CAY70530; PAS_chr3_0482.
DR   GeneID; 8199609; -.
DR   KEGG; ppa:PAS_chr3_0482; -.
DR   eggNOG; KOG0258; Eukaryota.
DR   HOGENOM; CLU_014254_3_0_1; -.
DR   InParanoid; C4R4P4; -.
DR   OMA; FGFECPP; -.
DR   OrthoDB; 5472891at2759; -.
DR   UniPathway; UPA00528; UER00586.
DR   Proteomes; UP000000314; Chromosome 3.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0008483; F:transaminase activity; IEA:InterPro.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   GO; GO:0042853; P:L-alanine catabolic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd00609; AAT_like; 1.
DR   Gene3D; 1.10.287.1970; -; 1.
DR   Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR045088; ALAT1/2-like.
DR   InterPro; IPR004839; Aminotransferase_I/II.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR   PANTHER; PTHR11751; ALANINE AMINOTRANSFERASE; 1.
DR   PANTHER; PTHR11751:SF29; ALANINE TRANSAMINASE; 1.
DR   Pfam; PF00155; Aminotran_1_2; 1.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000000314};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          120..491
FT                   /note="Aminotransferase class I/classII"
FT                   /evidence="ECO:0000259|Pfam:PF00155"
SQ   SEQUENCE   510 AA;  57011 MW;  06FA4BAB934E3C19 CRC64;
     MRVNKFIRPC RHMSSTTVVS LGLKIKPDFQ PAPKLTVTDL NPHTVNAKYA VRGKIPTKAE
     LLRNQLNDVD HKLPFTKIIS ANIGNPQQLD QKPLTFYRQI LALLQYPPLL DDPRVASIFP
     KDIIERARSL LKQIGSVGAY SQSQGVPSIR QSIADFISRR DGHPCARKEL IYLTTGASTA
     VTYLLTLLGQ NEKTGFLIPI PQYPLYTATL TLNNRTALPY YLNEEDNWSI ECDEIESIIL
     DSKAKGIDPR CLIVINPGNP TGAILSYEAI EDILNVCAKY GLVVIADEVY QENIFDGKFI
     SVRKVLLDLL QGPKADLYKN IQLASLHSTS KGISGECGQR GGYMELIGFD ESVLEQITKL
     SSISLCPVVT GQALVELMIN PPKEGDESYK LYYDETRAIH DSLAERATKL YDAFNSMEGV
     VCRKPQGAMY CFPKITIPEK AIKTAKELDF EPDEFYCNEL LETTGICAVP GSGFGQKPGT
     YHIRTTFLAP GSEWINDWVV FHKKFMQKYK
//