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C4R2P3

- MAP2_PICPG

UniProt

C4R2P3 - MAP2_PICPG

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Protein
Methionine aminopeptidase 2
Gene
MAP2, PAS_chr2-2_0159
Organism
Komagataella pastoris (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val) By similarity.UniRule annotation

Catalytic activityi

Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.UniRule annotation

Cofactori

Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe2+-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei198 – 1981Substrate By similarity
Metal bindingi218 – 2181Divalent metal cation 1 By similarity
Metal bindingi229 – 2291Divalent metal cation 1 By similarity
Metal bindingi229 – 2291Divalent metal cation 2; catalytic By similarity
Metal bindingi298 – 2981Divalent metal cation 2; catalytic; via tele nitrogen By similarity
Binding sitei306 – 3061Substrate By similarity
Metal bindingi331 – 3311Divalent metal cation 2; catalytic By similarity
Metal bindingi429 – 4291Divalent metal cation 1 By similarity
Metal bindingi429 – 4291Divalent metal cation 2; catalytic By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-HAMAP
  2. metalloaminopeptidase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. protein initiator methionine removal Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease

Keywords - Ligandi

Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine aminopeptidase 2 (EC:3.4.11.18)
Short name:
MAP 2
Short name:
MetAP 2
Alternative name(s):
Peptidase M
Gene namesi
Name:MAP2
Ordered Locus Names:PAS_chr2-2_0159
OrganismiKomagataella pastoris (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris)
Taxonomic identifieri644223 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKomagataella
ProteomesiUP000000314: Chromosome 2

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 448448Methionine aminopeptidase 2UniRule annotation
PRO_0000407664Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi644223.PAS_chr2-2_0159.

Structurei

3D structure databases

ProteinModelPortaliC4R2P3.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0024.
HOGENOMiHOG000226278.
KOiK01265.
OrthoDBiEOG7BGHW3.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.90.230.10. 2 hits.
HAMAPiMF_03175. MetAP_2_euk.
InterProiIPR001714. Pept_M24_MAP.
IPR000994. Pept_M24_structural-domain.
IPR002468. Pept_M24A_MAP2.
IPR018349. Pept_M24A_MAP2_BS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR10804:SF9. PTHR10804:SF9. 1 hit.
PfamiPF00557. Peptidase_M24. 1 hit.
[Graphical view]
PRINTSiPR00599. MAPEPTIDASE.
SUPFAMiSSF55920. SSF55920. 2 hits.
TIGRFAMsiTIGR00501. met_pdase_II. 1 hit.
PROSITEiPS01202. MAP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C4R2P3-1 [UniParc]FASTAAdd to Basket

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MTSSVDKVSQ KVADVKLGSS KSTKNNKSKG KGKSNKNQVV EDDDEDDFEK    50
ALELAMQLDA QKLAQKKADD VPLVEEEEKK VEEKIEQQYD PISTFYPDGN 100
YPQGEVVDYK DDNLYRTTDE EKRALDREKN NKWNEFRKGA EIHRRVRKLA 150
KDEIKPGMSM IEIAELIENA VRGYSGEDGL KGGMGFPCGL SLNHCAAHYS 200
PNANDKLVLN YEDVMKVDFG VHVNGHIIDS AFTLTFDDKY DDLLKAVKDA 250
TNTGIREAGI DVRLTDIGEA IQEVMESYEV TLDGETYQVK PIKNLCGHNI 300
GQYRIHGGKS VPIVKNFDNT KMEEGETFAI ETFGSTGRGH VIGQGECSHY 350
AKNPDAPANA ISSIRVNRAK QLLKTIDENF GTLPFCRRYI DRLGEEKYLL 400
ALNQLVKSGV VSDYPPLVDV KGSYTAQYEH TILLRPNVKE VVSRGEDY 448
Length:448
Mass (Da):50,204
Last modified:July 7, 2009 - v1
Checksum:i6BCE8381B94A08F1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FN392320 Genomic DNA. Translation: CAY69767.1.
RefSeqiXP_002492047.1. XM_002492002.1.

Genome annotation databases

EnsemblFungiiCAY69767; CAY69767; PAS_chr2-2_0159.
GeneIDi8198269.
KEGGippa:PAS_chr2-2_0159.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FN392320 Genomic DNA. Translation: CAY69767.1 .
RefSeqi XP_002492047.1. XM_002492002.1.

3D structure databases

ProteinModelPortali C4R2P3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 644223.PAS_chr2-2_0159.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CAY69767 ; CAY69767 ; PAS_chr2-2_0159 .
GeneIDi 8198269.
KEGGi ppa:PAS_chr2-2_0159.

Phylogenomic databases

eggNOGi COG0024.
HOGENOMi HOG000226278.
KOi K01265.
OrthoDBi EOG7BGHW3.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
3.90.230.10. 2 hits.
HAMAPi MF_03175. MetAP_2_euk.
InterProi IPR001714. Pept_M24_MAP.
IPR000994. Pept_M24_structural-domain.
IPR002468. Pept_M24A_MAP2.
IPR018349. Pept_M24A_MAP2_BS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
PANTHERi PTHR10804:SF9. PTHR10804:SF9. 1 hit.
Pfami PF00557. Peptidase_M24. 1 hit.
[Graphical view ]
PRINTSi PR00599. MAPEPTIDASE.
SUPFAMi SSF55920. SSF55920. 2 hits.
TIGRFAMsi TIGR00501. met_pdase_II. 1 hit.
PROSITEi PS01202. MAP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GS115 / ATCC 20864.

Entry informationi

Entry nameiMAP2_PICPG
AccessioniPrimary (citable) accession number: C4R2P3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: July 7, 2009
Last modified: May 14, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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