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C4R142

- C4R142_PICPG

UniProt

C4R142 - C4R142_PICPG

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Protein
Isocitrate dehydrogenase [NADP]
Gene
PAS_chr2-1_0580
Organism
Komagataella pastoris (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei99 – 991Substrate By similarityUniRule annotation
Binding sitei104 – 1041NADP By similarity
Binding sitei131 – 1311Substrate By similarityUniRule annotation
Binding sitei154 – 1541Substrate By similarityUniRule annotation
Sitei161 – 1611Critical for catalysis By similarityUniRule annotation
Sitei233 – 2331Critical for catalysis By similarityUniRule annotation
Metal bindingi273 – 2731Magnesium or manganese By similarityUniRule annotation
Binding sitei281 – 2811NADP By similarity
Metal bindingi296 – 2961Magnesium or manganese By similarityUniRule annotation
Binding sitei349 – 3491NADP; via amide nitrogen and carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi97 – 993NADP By similarity
Nucleotide bindingi331 – 3366NADP By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  3. magnesium ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:PAS_chr2-1_0580Imported
OrganismiKomagataella pastoris (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris)
Taxonomic identifieri644223 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKomagataella
ProteomesiUP000000314: Chromosome 2

Interactioni

Protein-protein interaction databases

STRINGi644223.PAS_chr2-1_0580.

Structurei

3D structure databases

ProteinModelPortaliC4R142.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni116 – 1227Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000019858.
KOiK00031.
OrthoDBiEOG7G4QQD.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C4R142-1 [UniParc]FASTAAdd to Basket

« Hide

MGKVTVFHLF FFFLGISYCK MAHAKISVKT PLVEMDGDEM TRIIWKLIKD    50
ELILPFLDID LKYYDLGIEY RDQTDDQVTI DAAEAIKKYG VGVKCATITP 100
DEARVEEFGL KKMWLSPNGT IRNILGGTVF REPIVIDNIP RIIPQWEKPI 150
IIGRHAYGDQ YRATDLLIPK AGELKLVFTP KDGSDPVETK VFDYPSAGVA 200
LTMYNLDDSI RDFALSSFKL ALEKKVNLFS TTKNTILKKY DGRFKDIFDE 250
TYETQFKESF EKAGIWYEHR LIDDMVAQML KSKGGYIIAM KNYDGDVQSD 300
IVAQGFGSLG LMTSVLTTPD GTAFESEAAH GTVTRHYRQH QQGKETSTNS 350
IASIFAWTRG LIQRGLLDNT LPVVEFGQLL ENATINTVKL DGIMTKDLAL 400
ARGETDRSSY VNTEEFIKAV AKRLTSEFEA KF 432
Length:432
Mass (Da):48,755
Last modified:July 7, 2009 - v1
Checksum:i17B43CA9069AFC76
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FN392320 Genomic DNA. Translation: CAY69216.1.
RefSeqiXP_002491496.1. XM_002491451.1.

Genome annotation databases

EnsemblFungiiCAY69216; CAY69216; PAS_chr2-1_0580.
GeneIDi8198933.
KEGGippa:PAS_chr2-1_0580.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FN392320 Genomic DNA. Translation: CAY69216.1 .
RefSeqi XP_002491496.1. XM_002491451.1.

3D structure databases

ProteinModelPortali C4R142.
ModBasei Search...

Protein-protein interaction databases

STRINGi 644223.PAS_chr2-1_0580.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CAY69216 ; CAY69216 ; PAS_chr2-1_0580 .
GeneIDi 8198933.
KEGGi ppa:PAS_chr2-1_0580.

Phylogenomic databases

eggNOGi COG0538.
HOGENOMi HOG000019858.
KOi K00031.
OrthoDBi EOG7G4QQD.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GS115 / ATCC 20864.

Entry informationi

Entry nameiC4R142_PICPG
AccessioniPrimary (citable) accession number: C4R142
Entry historyi
Integrated into UniProtKB/TrEMBL: July 7, 2009
Last sequence update: July 7, 2009
Last modified: July 9, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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