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C4R142

- C4R142_PICPG

UniProt

C4R142 - C4R142_PICPG

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Protein

Isocitrate dehydrogenase [NADP]

Gene

PAS_chr2-1_0580

Organism
Komagataella pastoris (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Note: Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei104 – 1041NADPUniRule annotation
Binding sitei154 – 1541SubstrateUniRule annotation
Sitei161 – 1611Critical for catalysisUniRule annotation
Sitei233 – 2331Critical for catalysisUniRule annotation
Metal bindingi273 – 2731Magnesium or manganeseUniRule annotation
Binding sitei281 – 2811NADPUniRule annotation
Metal bindingi296 – 2961Magnesium or manganeseUniRule annotation
Binding sitei349 – 3491NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi97 – 993NADPUniRule annotation
Nucleotide bindingi331 – 3366NADPUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:PAS_chr2-1_0580Imported
OrganismiKomagataella pastoris (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris)Imported
Taxonomic identifieri644223 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesPhaffomycetaceaeKomagataella
ProteomesiUP000000314: Chromosome 2

Interactioni

Protein-protein interaction databases

STRINGi644223.PAS_chr2-1_0580.

Structurei

3D structure databases

ProteinModelPortaliC4R142.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000019858.
InParanoidiC4R142.
KOiK00031.
OrthoDBiEOG7G4QQD.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C4R142-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGKVTVFHLF FFFLGISYCK MAHAKISVKT PLVEMDGDEM TRIIWKLIKD
60 70 80 90 100
ELILPFLDID LKYYDLGIEY RDQTDDQVTI DAAEAIKKYG VGVKCATITP
110 120 130 140 150
DEARVEEFGL KKMWLSPNGT IRNILGGTVF REPIVIDNIP RIIPQWEKPI
160 170 180 190 200
IIGRHAYGDQ YRATDLLIPK AGELKLVFTP KDGSDPVETK VFDYPSAGVA
210 220 230 240 250
LTMYNLDDSI RDFALSSFKL ALEKKVNLFS TTKNTILKKY DGRFKDIFDE
260 270 280 290 300
TYETQFKESF EKAGIWYEHR LIDDMVAQML KSKGGYIIAM KNYDGDVQSD
310 320 330 340 350
IVAQGFGSLG LMTSVLTTPD GTAFESEAAH GTVTRHYRQH QQGKETSTNS
360 370 380 390 400
IASIFAWTRG LIQRGLLDNT LPVVEFGQLL ENATINTVKL DGIMTKDLAL
410 420 430
ARGETDRSSY VNTEEFIKAV AKRLTSEFEA KF
Length:432
Mass (Da):48,755
Last modified:July 7, 2009 - v1
Checksum:i17B43CA9069AFC76
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN392320 Genomic DNA. Translation: CAY69216.1.
RefSeqiXP_002491496.1. XM_002491451.1.

Genome annotation databases

EnsemblFungiiCAY69216; CAY69216; PAS_chr2-1_0580.
GeneIDi8198933.
KEGGippa:PAS_chr2-1_0580.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN392320 Genomic DNA. Translation: CAY69216.1 .
RefSeqi XP_002491496.1. XM_002491451.1.

3D structure databases

ProteinModelPortali C4R142.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 644223.PAS_chr2-1_0580.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CAY69216 ; CAY69216 ; PAS_chr2-1_0580 .
GeneIDi 8198933.
KEGGi ppa:PAS_chr2-1_0580.

Phylogenomic databases

eggNOGi COG0538.
HOGENOMi HOG000019858.
InParanoidi C4R142.
KOi K00031.
OrthoDBi EOG7G4QQD.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GS115 / ATCC 20864Imported.

Entry informationi

Entry nameiC4R142_PICPG
AccessioniPrimary (citable) accession number: C4R142
Entry historyi
Integrated into UniProtKB/TrEMBL: July 7, 2009
Last sequence update: July 7, 2009
Last modified: November 26, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3