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C4R142

- C4R142_PICPG

UniProt

C4R142 - C4R142_PICPG

Protein

Isocitrate dehydrogenase [NADP]

Gene

PAS_chr2-1_0580

Organism
Komagataella pastoris (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (07 Jul 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei99 – 991Substrate
    Binding sitei104 – 1041NADPUniRule annotation
    Binding sitei131 – 1311Substrate
    Binding sitei154 – 1541SubstrateUniRule annotation
    Sitei161 – 1611Critical for catalysisUniRule annotation
    Sitei233 – 2331Critical for catalysisUniRule annotation
    Metal bindingi273 – 2731Magnesium or manganeseUniRule annotation
    Binding sitei281 – 2811NADPUniRule annotation
    Metal bindingi296 – 2961Magnesium or manganeseUniRule annotation
    Binding sitei349 – 3491NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi97 – 993NADPUniRule annotation
    Nucleotide bindingi331 – 3366NADPUniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. isocitrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Biological processi

    Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Ordered Locus Names:PAS_chr2-1_0580Imported
    OrganismiKomagataella pastoris (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris)Imported
    Taxonomic identifieri644223 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKomagataella
    ProteomesiUP000000314: Chromosome 2

    Interactioni

    Protein-protein interaction databases

    STRINGi644223.PAS_chr2-1_0580.

    Structurei

    3D structure databases

    ProteinModelPortaliC4R142.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni116 – 1227Substrate binding

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0538.
    HOGENOMiHOG000019858.
    KOiK00031.
    OrthoDBiEOG7G4QQD.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11822. PTHR11822. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C4R142-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGKVTVFHLF FFFLGISYCK MAHAKISVKT PLVEMDGDEM TRIIWKLIKD    50
    ELILPFLDID LKYYDLGIEY RDQTDDQVTI DAAEAIKKYG VGVKCATITP 100
    DEARVEEFGL KKMWLSPNGT IRNILGGTVF REPIVIDNIP RIIPQWEKPI 150
    IIGRHAYGDQ YRATDLLIPK AGELKLVFTP KDGSDPVETK VFDYPSAGVA 200
    LTMYNLDDSI RDFALSSFKL ALEKKVNLFS TTKNTILKKY DGRFKDIFDE 250
    TYETQFKESF EKAGIWYEHR LIDDMVAQML KSKGGYIIAM KNYDGDVQSD 300
    IVAQGFGSLG LMTSVLTTPD GTAFESEAAH GTVTRHYRQH QQGKETSTNS 350
    IASIFAWTRG LIQRGLLDNT LPVVEFGQLL ENATINTVKL DGIMTKDLAL 400
    ARGETDRSSY VNTEEFIKAV AKRLTSEFEA KF 432
    Length:432
    Mass (Da):48,755
    Last modified:July 7, 2009 - v1
    Checksum:i17B43CA9069AFC76
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FN392320 Genomic DNA. Translation: CAY69216.1.
    RefSeqiXP_002491496.1. XM_002491451.1.

    Genome annotation databases

    EnsemblFungiiCAY69216; CAY69216; PAS_chr2-1_0580.
    GeneIDi8198933.
    KEGGippa:PAS_chr2-1_0580.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FN392320 Genomic DNA. Translation: CAY69216.1 .
    RefSeqi XP_002491496.1. XM_002491451.1.

    3D structure databases

    ProteinModelPortali C4R142.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 644223.PAS_chr2-1_0580.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CAY69216 ; CAY69216 ; PAS_chr2-1_0580 .
    GeneIDi 8198933.
    KEGGi ppa:PAS_chr2-1_0580.

    Phylogenomic databases

    eggNOGi COG0538.
    HOGENOMi HOG000019858.
    KOi K00031.
    OrthoDBi EOG7G4QQD.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11822. PTHR11822. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: GS115 / ATCC 20864Imported.

    Entry informationi

    Entry nameiC4R142_PICPG
    AccessioniPrimary (citable) accession number: C4R142
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 7, 2009
    Last sequence update: July 7, 2009
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3