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C4QZV7 (KEX1_PICPG) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pheromone-processing carboxypeptidase KEX1

EC=3.4.16.6
Alternative name(s):
Carboxypeptidase D
Gene names
Name:KEX1
Ordered Locus Names:PAS_chr2-1_0174
OrganismKomagataella pastoris (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris) [Reference proteome]
Taxonomic identifier644223 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKomagataella

Protein attributes

Sequence length623 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.

Catalytic activity

Preferential release of a C-terminal arginine or lysine residue.

Subcellular location

Golgi apparatustrans-Golgi network membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Belongs to the peptidase S10 family.

Ontologies

Keywords
   Biological processApoptosis
   Cellular componentGolgi apparatus
Membrane
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionCarboxypeptidase
Hydrolase
Protease
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processapoptotic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionserine-type carboxypeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1616 Potential
Chain17 – 623607Pheromone-processing carboxypeptidase KEX1
PRO_0000411940

Regions

Topological domain17 – 512496Lumenal Potential
Transmembrane513 – 53321Helical; Potential
Topological domain534 – 62390Cytoplasmic Potential

Sites

Active site1771 By similarity
Active site3831 By similarity
Active site4411 By similarity

Amino acid modifications

Glycosylation541N-linked (GlcNAc...) Potential
Glycosylation2581N-linked (GlcNAc...) Potential
Glycosylation4301N-linked (GlcNAc...) Potential
Glycosylation4381N-linked (GlcNAc...) Potential
Glycosylation4691N-linked (GlcNAc...) Potential
Glycosylation4831N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
C4QZV7 [UniParc].

Last modified July 7, 2009. Version 1.
Checksum: CC7B0683829D8FDB

FASTA62370,018
        10         20         30         40         50         60 
MLKLLCLLLP LVAVSASPID LGSQKDYLVL DLPGLSHLSE TQRPTMHAGL LPLNLSFVAD 

        70         80         90        100        110        120 
DDTEYFFWRF SKQDVDRADI VFWLNGGPGC SSMDGALMEL GPFVINPKQE VEYNEGTWVE 

       130        140        150        160        170        180 
AADVVFVDQP GGTGFSSTTN YLTELTEVAD GFVTFLARYF HLFPADVYKK FTLGGESYAG 

       190        200        210        220        230        240 
QYVPYILKAI MDDLKSDSGQ LPKELYLKGA LIGNGWIDPN EQSLSYLEFF IKKELIDIHG 

       250        260        270        280        290        300 
SYMPGLLQQQ EKCQNLINHS SGEASESQIS YSACEKILND ALRFTRDKKA PLDQQCINMY 

       310        320        330        340        350        360 
DYTLRDTYPS CGMSWPPYLP DVTAFLQKKS VLEALHLDSS ASWSECSARV GSHLKNKISV 

       370        380        390        400        410        420 
PSVDILPDLL QEIPIILFNG DHDIICNCIG TERMIDKLEF NGDQGFTEGT EYIPWFYNEV 

       430        440        450        460        470        480 
NVGKVISERN LTYVRVYNSS HMVPFDNTPV SRGLLDIYFD NFEDVEYNNV SGIATPVYDV 

       490        500        510        520        530        540 
DKNITYIDSN DPRLQNGPKS SSTDDSAAHG NPFFYYVFEL FVIVLLLCGL VYLYQYYSNS 

       550        560        570        580        590        600 
APHSILADKH KKKSKNKSKN VRFLDDLESN LDLDNTDDKK DNSVMSKLLS SMGYQAQEPY 

       610        620 
KPLDKGANAD LDIEMDSHGT SEK 

« Hide

References

[1]"Genome sequence of the recombinant protein production host Pichia pastoris."
De Schutter K., Lin Y.-C., Tiels P., Van Hecke A., Glinka S., Weber-Lehmann J., Rouze P., Van de Peer Y., Callewaert N.
Nat. Biotechnol. 27:561-566(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: GS115 / ATCC 20864.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FN392320 Genomic DNA. Translation: CAY68781.1.
RefSeqXP_002491061.1. XM_002491016.1.

3D structure databases

ProteinModelPortalC4QZV7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING644223.PAS_chr2-1_0174.

Protein family/group databases

MEROPSS10.007.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCAY68781; CAY68781; PAS_chr2-1_0174.
GeneID8198557.
KEGGppa:PAS_chr2-1_0174.

Phylogenomic databases

eggNOGCOG2939.
KOK01288.
OrthoDBEOG7TJ3SJ.

Family and domain databases

Gene3D3.40.50.1820. 1 hit.
InterProIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERPTHR11802. PTHR11802. 1 hit.
PfamPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSPR00724. CRBOXYPTASEC.
SUPFAMSSF53474. SSF53474. 1 hit.
PROSITEPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKEX1_PICPG
AccessionPrimary (citable) accession number: C4QZV7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 7, 2009
Last modified: June 11, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries