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Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei177PROSITE-ProRule annotation1
Active sitei383PROSITE-ProRule annotation1
Active sitei441PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

ESTHERipicpa-KEX1. Carboxypeptidase_S10.
MEROPSiS10.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
Ordered Locus Names:PAS_chr2-1_0174
OrganismiKomagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris)
Taxonomic identifieri644223 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesPhaffomycetaceaeKomagataella
Proteomesi
  • UP000000314 Componenti: Chromosome 2

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini17 – 512LumenalSequence analysisAdd BLAST496
Transmembranei513 – 533HelicalSequence analysisAdd BLAST21
Topological domaini534 – 623CytoplasmicSequence analysisAdd BLAST90

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000041194017 – 623Pheromone-processing carboxypeptidase KEX1Add BLAST607

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi54N-linked (GlcNAc...)Sequence analysis1
Glycosylationi258N-linked (GlcNAc...)Sequence analysis1
Glycosylationi430N-linked (GlcNAc...)Sequence analysis1
Glycosylationi438N-linked (GlcNAc...)Sequence analysis1
Glycosylationi469N-linked (GlcNAc...)Sequence analysis1
Glycosylationi483N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi644223.XP_002491061.1.

Structurei

3D structure databases

ProteinModelPortaliC4QZV7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1282. Eukaryota.
COG2939. LUCA.
InParanoidiC4QZV7.
KOiK01288.
OMAiSYPACGS.
OrthoDBiEOG092C255X.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C4QZV7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKLLCLLLP LVAVSASPID LGSQKDYLVL DLPGLSHLSE TQRPTMHAGL
60 70 80 90 100
LPLNLSFVAD DDTEYFFWRF SKQDVDRADI VFWLNGGPGC SSMDGALMEL
110 120 130 140 150
GPFVINPKQE VEYNEGTWVE AADVVFVDQP GGTGFSSTTN YLTELTEVAD
160 170 180 190 200
GFVTFLARYF HLFPADVYKK FTLGGESYAG QYVPYILKAI MDDLKSDSGQ
210 220 230 240 250
LPKELYLKGA LIGNGWIDPN EQSLSYLEFF IKKELIDIHG SYMPGLLQQQ
260 270 280 290 300
EKCQNLINHS SGEASESQIS YSACEKILND ALRFTRDKKA PLDQQCINMY
310 320 330 340 350
DYTLRDTYPS CGMSWPPYLP DVTAFLQKKS VLEALHLDSS ASWSECSARV
360 370 380 390 400
GSHLKNKISV PSVDILPDLL QEIPIILFNG DHDIICNCIG TERMIDKLEF
410 420 430 440 450
NGDQGFTEGT EYIPWFYNEV NVGKVISERN LTYVRVYNSS HMVPFDNTPV
460 470 480 490 500
SRGLLDIYFD NFEDVEYNNV SGIATPVYDV DKNITYIDSN DPRLQNGPKS
510 520 530 540 550
SSTDDSAAHG NPFFYYVFEL FVIVLLLCGL VYLYQYYSNS APHSILADKH
560 570 580 590 600
KKKSKNKSKN VRFLDDLESN LDLDNTDDKK DNSVMSKLLS SMGYQAQEPY
610 620
KPLDKGANAD LDIEMDSHGT SEK
Length:623
Mass (Da):70,018
Last modified:July 7, 2009 - v1
Checksum:iCC7B0683829D8FDB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN392320 Genomic DNA. Translation: CAY68781.1.
RefSeqiXP_002491061.1. XM_002491016.1.

Genome annotation databases

EnsemblFungiiCAY68781; CAY68781; PAS_chr2-1_0174.
GeneIDi8198557.
KEGGippa:PAS_chr2-1_0174.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN392320 Genomic DNA. Translation: CAY68781.1.
RefSeqiXP_002491061.1. XM_002491016.1.

3D structure databases

ProteinModelPortaliC4QZV7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi644223.XP_002491061.1.

Protein family/group databases

ESTHERipicpa-KEX1. Carboxypeptidase_S10.
MEROPSiS10.007.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAY68781; CAY68781; PAS_chr2-1_0174.
GeneIDi8198557.
KEGGippa:PAS_chr2-1_0174.

Phylogenomic databases

eggNOGiKOG1282. Eukaryota.
COG2939. LUCA.
InParanoidiC4QZV7.
KOiK01288.
OMAiSYPACGS.
OrthoDBiEOG092C255X.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKEX1_KOMPG
AccessioniPrimary (citable) accession number: C4QZV7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 7, 2009
Last modified: November 2, 2016
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.