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Protein

DNA-directed RNA polymerase subunit beta

Gene

PAS_chr2-1_0125

Organism
Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.UniRule annotation

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi1163ZincCombined sources1
Metal bindingi1166ZincCombined sources1
Metal bindingi1182ZincCombined sources1
Metal bindingi1185ZincCombined sources1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferaseUniRule annotation, Transferase
Biological processTranscription
LigandMetal-bindingCombined sources, ZincCombined sources

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase subunit betaUniRule annotation (EC:2.7.7.6UniRule annotation)
Gene namesi
Ordered Locus Names:PAS_chr2-1_0125Imported
OrganismiKomagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris)Imported
Taxonomic identifieri644223 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesPhaffomycetaceaeKomagataella
Proteomesi
  • UP000000314 Componenti: Chromosome 2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

DNA-directed RNA polymeraseUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi644223.XP_002491011.1.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5X4ZX-ray7.80B/N1-1227[»]
5X50X-ray4.29B1-1227[»]
5X51X-ray7.00B/N1-1227[»]
5XOGX-ray3.00B1-1227[»]
5XONelectron microscopy3.83B1-1227[»]
SMRiC4QZQ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 448RNA_pol_Rpb2_1InterPro annotationAdd BLAST420
Domaini211 – 400RNA_pol_Rpb2_2InterPro annotationAdd BLAST190
Domaini474 – 536RNA_pol_Rpb2_3InterPro annotationAdd BLAST63
Domaini573 – 634RNA_pol_Rpb2_4InterPro annotationAdd BLAST62
Domaini678 – 745RNA_pol_Rpb2_5InterPro annotationAdd BLAST68
Domaini753 – 1124RNA_pol_Rpb2_6InterPro annotationAdd BLAST372
Domaini1126 – 1218RNA_pol_Rpb2_7InterPro annotationAdd BLAST93

Sequence similaritiesi

Belongs to the RNA polymerase beta chain family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0214. Eukaryota.
COG0085. LUCA.
HOGENOMiHOG000222962.
InParanoidiC4QZQ7.
KOiK03010.
OMAiQKKAMSS.
OrthoDBiEOG092C06IY.

Family and domain databases

CDDicd00653. RNA_pol_B_RPB2. 1 hit.
InterProiView protein in InterPro
IPR015712. DNA-dir_RNA_pol_su2.
IPR007120. DNA-dir_RNA_pol_su2_6.
IPR007121. RNA_pol_bsu_CS.
IPR007644. RNA_pol_bsu_protrusion.
IPR007642. RNA_pol_Rpb2_2.
IPR007645. RNA_pol_Rpb2_3.
IPR007646. RNA_pol_Rpb2_4.
IPR007647. RNA_pol_Rpb2_5.
IPR007641. RNA_pol_Rpb2_7.
PANTHERiPTHR20856. PTHR20856. 1 hit.
PfamiView protein in Pfam
PF04563. RNA_pol_Rpb2_1. 1 hit.
PF04561. RNA_pol_Rpb2_2. 1 hit.
PF04565. RNA_pol_Rpb2_3. 1 hit.
PF04566. RNA_pol_Rpb2_4. 1 hit.
PF04567. RNA_pol_Rpb2_5. 1 hit.
PF00562. RNA_pol_Rpb2_6. 1 hit.
PF04560. RNA_pol_Rpb2_7. 1 hit.
PROSITEiView protein in PROSITE
PS01166. RNA_POL_BETA. 1 hit.

Sequencei

Sequence statusi: Complete.

C4QZQ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYDPYSIDD TITTEDCWTV ISAFFEEKGL VSQQLDSFDE FMETSIQDLV
60 70 80 90 100
WEEPRLILDQ PAQHTNEKDN INKRYEIRFG KIYLSRPTMT EADGTTHAMF
110 120 130 140 150
PQEARLRNLT YSSPVYLDME KSMFTSIDDE GNPNATLDWQ QVHEPIKDGV
160 170 180 190 200
EEGNKVHIGK VPIMLRSKFC SLRTLDEVDL YKMKECPYDM GGYFVINGSE
210 220 230 240 250
KVLIAQERSA ANIVQVFKKA APSPISHVAE IRSALEKGSR LISTMQIKLY
260 270 280 290 300
GREDKGTGRT IKATLPYVKQ DIPIVIVFRA LGVVPDGEIL QHICYDENDW
310 320 330 340 350
QMLEMLKPCI EEGFVIQDKE VALDFIGRRG SAALGIRREK RIQYAKDILQ
360 370 380 390 400
KELLPHITQE EGFETRKTFF LGYMVNRLLL CALERKDQDD RDHFGKKRLD
410 420 430 440 450
LAGPLLANLF RILFRKLTRE IYRYMQRCIE TDRDFNLNLA VKSTTITSGL
460 470 480 490 500
KYSLATGNWG EQKKAMSSRA GVSQVLNRYT YSSTLSHLRR TNTPIGRDGK
510 520 530 540 550
LAKPRQLHNT HWGLVCPAET PEGQACGLVK NLSLLSGISI GSPSEPIINF
560 570 580 590 600
LEEWGMEPLE DYDPAQHTKS TRIFVNGVWT GIHRDPSMLV STMRDLRRSG
610 620 630 640 650
AISPEVSIIR DIREREFKIF TDVGRVYRPL FIVEDDESKD NKGELRITKE
660 670 680 690 700
HIRKIQQGYD DDAMNDDSEE QEQDVYGWSS LVTSGVIEYV DGEEEETIMI
710 720 730 740 750
AMTPEDLQTR SLEQKEIDLN DTAKRIKPEM STSSHHTFTH CEIHPSMILG
760 770 780 790 800
VAASIIPFPD HNQSPRNTYQ SAMGKQAMGV FLTNYNVRMD TMANILYYPQ
810 820 830 840 850
KPLAKTQAME YLKFRELPAG QNAIVAIACY SGYNQEDSMI MNQSSIDRGL
860 870 880 890 900
FRSLFFRSYM DQEKRFGISI VEEFEKPTRA TTLRLKHGTY EKLDEDGLIA
910 920 930 940 950
PGVRVSGDDI IIGKTTPIPP DTEELGQRTK YHTKRDASTP LRSTENGIVD
960 970 980 990 1000
QVLLTTNQEG LKFVKVRMRT TKVPQIGDKF ASRHGQKGTI GVTYRHEDMP
1010 1020 1030 1040 1050
FSAEGIVPDL IINPHAIPSR MTVAHLIECL LSKVGSIRGY EGDATPFTDL
1060 1070 1080 1090 1100
TVDAVSNLLR DNGYQSRGFE VMYNGHTGKK LMAQVFFGPT YYQRLRHMVD
1110 1120 1130 1140 1150
DKIHARARGP VQVLTRQPVE GRSRDGGLRF GEMERDCMIA HGAAGFLKER
1160 1170 1180 1190 1200
LMEASDAFRV HVCGICGLMS VIANLKKNQF ECRSCKNKTN IYQLHIPYAA
1210 1220
KLLFQELMAM NIAPRLYTER SGVSMRS
Length:1,227
Mass (Da):139,558
Last modified:July 7, 2009 - v1
Checksum:iDEDCC2338773A4A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN392320 Genomic DNA. Translation: CAY68731.1.
RefSeqiXP_002491011.1. XM_002490966.1.

Genome annotation databases

EnsemblFungiiCAY68731; CAY68731; PAS_chr2-1_0125.
GeneIDi8198521.
KEGGippa:PAS_chr2-1_0125.

Similar proteinsi

Entry informationi

Entry nameiC4QZQ7_KOMPG
AccessioniPrimary (citable) accession number: C4QZQ7
Entry historyiIntegrated into UniProtKB/TrEMBL: July 7, 2009
Last sequence update: July 7, 2009
Last modified: October 25, 2017
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported