ID   C4QYH5_KOMPG            Unreviewed;       474 AA.
AC   C4QYH5;
DT   07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   07-JUL-2009, sequence version 1.
DT   27-MAR-2024, entry version 75.
DE   RecName: Full=Phosphotransferase {ECO:0000256|RuleBase:RU362007};
DE            EC=2.7.1.- {ECO:0000256|RuleBase:RU362007};
GN   OrderedLocusNames=PAS_chr1-4_0447 {ECO:0000313|EMBL:CAY68298.1};
OS   Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Phaffomycetaceae; Komagataella.
OX   NCBI_TaxID=644223 {ECO:0000313|EMBL:CAY68298.1, ECO:0000313|Proteomes:UP000000314};
RN   [1] {ECO:0000313|EMBL:CAY68298.1, ECO:0000313|Proteomes:UP000000314}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GS115 / ATCC 20864 {ECO:0000313|Proteomes:UP000000314};
RX   PubMed=19465926; DOI=10.1038/nbt.1544;
RA   De Schutter K., Lin Y.C., Tiels P., Van Hecke A., Glinka S.,
RA   Weber-Lehmann J., Rouze P., Van de Peer Y., Callewaert N.;
RT   "Genome sequence of the recombinant protein production host Pichia
RT   pastoris.";
RL   Nat. Biotechnol. 27:561-566(2009).
CC   -!- SIMILARITY: Belongs to the hexokinase family.
CC       {ECO:0000256|ARBA:ARBA00009225, ECO:0000256|RuleBase:RU362007}.
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DR   EMBL; FN392319; CAY68298.1; -; Genomic_DNA.
DR   RefSeq; XP_002490579.1; XM_002490534.1.
DR   AlphaFoldDB; C4QYH5; -.
DR   SMR; C4QYH5; -.
DR   STRING; 644223.C4QYH5; -.
DR   EnsemblFungi; CAY68298; CAY68298; PAS_chr1-4_0447.
DR   GeneID; 8197035; -.
DR   KEGG; ppa:PAS_chr1-4_0447; -.
DR   eggNOG; KOG1369; Eukaryota.
DR   HOGENOM; CLU_014393_4_1_1; -.
DR   InParanoid; C4QYH5; -.
DR   OMA; FPVEQTS; -.
DR   OrthoDB; 5481886at2759; -.
DR   UniPathway; UPA00109; UER00180.
DR   Proteomes; UP000000314; Chromosome 1.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0005536; F:glucose binding; IEA:InterPro.
DR   GO; GO:0004396; F:hexokinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0001678; P:intracellular glucose homeostasis; IEA:InterPro.
DR   Gene3D; 3.30.420.40; -; 1.
DR   Gene3D; 3.40.367.20; -; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR001312; Hexokinase.
DR   InterPro; IPR022673; Hexokinase_C.
DR   InterPro; IPR022672; Hexokinase_N.
DR   PANTHER; PTHR19443; HEXOKINASE; 1.
DR   PANTHER; PTHR19443:SF24; HEXOKINASE YLR446W-RELATED; 1.
DR   Pfam; PF00349; Hexokinase_1; 1.
DR   Pfam; PF03727; Hexokinase_2; 1.
DR   PRINTS; PR00475; HEXOKINASE.
DR   SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR   PROSITE; PS51748; HEXOKINASE_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU362007};
KW   Glycolysis {ECO:0000256|RuleBase:RU362007};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|RuleBase:RU362007};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU362007};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000314};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU362007}.
FT   DOMAIN          24..202
FT                   /note="Hexokinase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00349"
FT   DOMAIN          208..470
FT                   /note="Hexokinase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03727"
SQ   SEQUENCE   474 AA;  52321 MW;  9F8459EB7D6D80E1 CRC64;
     MVPVLTPQFH SSPSVSDFTA FINRSNVVSI TSNLYESYKE AIHSSNVSMY CTNSSTPTGN
     ECGTCLVVEL GGSTLRIAVL RLEKRKYENL YQRDWTLTES DKVIDLKFFD EIAQKITNIP
     SLRSHFRNDT IRIGISWSFP LEQTSSSQAV LQTMGKGFRL SESTHGQDLK TLFENSLKSN
     GIDASVESII NDSVAVFVAG NYLESCVTGL VAGTGVNCAL VVDRKMIGLQ KSQEQIRPLR
     KGNFDKVVLN SELGFFGGFL CQHSTIWDKM VHENWALHHS VQTNQPHMTL ALGCFQPIEM
     MCSGRYIGEL TRLAILSLID SKQLFKGSRQ NIPSAFNVPY SLGGAIVSEI YESEGHLPEL
     WAPLAPSQED YQILFKVVDS IIERASVVLG CAIIALLKLS ESSATIDPTG SGSCRPYRIG
     YVGSVLKCFK PYREKVEMVL NLASKLQIIN RPASLIYIDD SNLVGAAVSV FTPE
//