ID   C4QW41_KOMPG            Unreviewed;       589 AA.
AC   C4QW41;
DT   07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   07-JUL-2009, sequence version 1.
DT   27-MAR-2024, entry version 89.
DE   SubName: Full=Histone methyltransferase with a role in transcriptional elongation {ECO:0000313|EMBL:CAY67464.1};
GN   OrderedLocusNames=PAS_chr1-1_0102 {ECO:0000313|EMBL:CAY67464.1};
OS   Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Phaffomycetaceae; Komagataella.
OX   NCBI_TaxID=644223 {ECO:0000313|EMBL:CAY67464.1, ECO:0000313|Proteomes:UP000000314};
RN   [1] {ECO:0000313|EMBL:CAY67464.1, ECO:0000313|Proteomes:UP000000314}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GS115 / ATCC 20864 {ECO:0000313|Proteomes:UP000000314};
RX   PubMed=19465926; DOI=10.1038/nbt.1544;
RA   De Schutter K., Lin Y.C., Tiels P., Van Hecke A., Glinka S.,
RA   Weber-Lehmann J., Rouze P., Van de Peer Y., Callewaert N.;
RT   "Genome sequence of the recombinant protein production host Pichia
RT   pastoris.";
RL   Nat. Biotechnol. 27:561-566(2009).
CC   -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC       Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   EMBL; FN392319; CAY67464.1; -; Genomic_DNA.
DR   RefSeq; XP_002489745.1; XM_002489700.1.
DR   AlphaFoldDB; C4QW41; -.
DR   SMR; C4QW41; -.
DR   STRING; 644223.C4QW41; -.
DR   EnsemblFungi; CAY67464; CAY67464; PAS_chr1-1_0102.
DR   GeneID; 8197228; -.
DR   KEGG; ppa:PAS_chr1-1_0102; -.
DR   eggNOG; KOG4442; Eukaryota.
DR   HOGENOM; CLU_463154_0_0_1; -.
DR   InParanoid; C4QW41; -.
DR   OrthoDB; 950362at2759; -.
DR   Proteomes; UP000000314; Chromosome 1.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0042054; F:histone methyltransferase activity; IEA:InterPro.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 2.170.270.10; SET domain; 1.
DR   InterPro; IPR006560; AWS_dom.
DR   InterPro; IPR003616; Post-SET_dom.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   PANTHER; PTHR22884:SF413; HISTONE-LYSINE N-METHYLTRANSFERASE CG1716-RELATED; 1.
DR   PANTHER; PTHR22884; SET DOMAIN PROTEINS; 1.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00317; SET; 1.
DR   SUPFAM; SSF82199; SET domain; 1.
DR   PROSITE; PS51215; AWS; 1.
DR   PROSITE; PS50868; POST_SET; 1.
DR   PROSITE; PS50280; SET; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000313|EMBL:CAY67464.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000314};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          181..227
FT                   /note="AWS"
FT                   /evidence="ECO:0000259|PROSITE:PS51215"
FT   DOMAIN          236..352
FT                   /note="SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50280"
FT   DOMAIN          360..376
FT                   /note="Post-SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50868"
FT   REGION          377..427
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          513..563
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        381..397
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        398..427
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        528..542
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        543..563
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   589 AA;  66686 MW;  CDADA00A8F0AC059 CRC64;
     MLASQSEEEP FSFYMWCDMP SRPSRNSLKD STYLPLSELL EHGEAPTTRP SRKLTRSIEQ
     CKKWVACIDH SNFPGHWSVG KRGCRTKVQL QMQLILSAAT GSPLKLWIFS QRGLEVVSFL
     LIPKPEALQF VSPTRKQKRK IVSLPNSNFR ATTAEWANLA KNIWRSSKEH DKVIKNSRSL
     RDYNSCNCRV NCGDLCLNRI LQIECDSTIC KLSETRSCGN TQFTTLELGI SSLFREGTRV
     CRIDDKKGYG LVAIREFAPY ELICEYTGEV INQEVVKERL SKKKVFHYYH LSLEQGLSID
     STVKGSVARF VNHSCAPNAE VQKWYVQDEP RIGLFAGSKG IIPGDEITYD YNFIWLENAE
     PQLCYCQSAN CRGVIGKKHS PSPVSQPTKS SKRTPQEGSQ PSRKRGQHKI KDNQLLKTEK
     DTDARRLRRS IRHKGLAPDV GNTLQRLPLH VRKQLSIDMA PPGKADDISR QLLAVLLPTE
     GRTRSSRQRK VVEACIKTGI PLKYTGLDIK EPFPKKRVNK RNSARKLRSS SKSSSTSKKS
     ASETLILKEE PKNHPPPPRV SEKLKIAHII HSSEESLSSI PFHPINQIN
//