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C4PZQ3

- LIAS_SCHMA

UniProt

C4PZQ3 - LIAS_SCHMA

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Protein
Lipoyl synthase, mitochondrial
Gene
Smp_010100
Organism
Schistosoma mansoni (Blood fluke)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives By similarity.UniRule annotation

Catalytic activityi

Protein N(6)-(octanoyl)lysine + 2 sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine = protein N(6)-(lipoyl)lysine + 2 (sulfur carrier) + 2 L-methionine + 2 5'-deoxyadenosine.UniRule annotation

Cofactori

Binds 2 4Fe-4S clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi134 – 1341Iron-sulfur 1 (4Fe-4S) By similarity
Metal bindingi139 – 1391Iron-sulfur 1 (4Fe-4S) By similarity
Metal bindingi145 – 1451Iron-sulfur 1 (4Fe-4S) By similarity
Metal bindingi165 – 1651Iron-sulfur 2 (4Fe-4S-S-AdoMet) By similarity
Metal bindingi169 – 1691Iron-sulfur 2 (4Fe-4S-S-AdoMet) By similarity
Metal bindingi172 – 1721Iron-sulfur 2 (4Fe-4S-S-AdoMet) By similarity

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-HAMAP
  2. lipoate synthase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. protein lipoylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00538; UER00593.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipoyl synthase, mitochondrial (EC:2.8.1.8)
Alternative name(s):
Lipoate synthase
Short name:
LS
Short name:
Lip-syn
Lipoic acid synthase
Gene namesi
ORF Names:Smp_010100
OrganismiSchistosoma mansoni (Blood fluke)
Taxonomic identifieri6183 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaStrigeididaSchistosomatoideaSchistosomatidaeSchistosoma
ProteomesiUP000008854: Chromosome 3

Subcellular locationi

Mitochondrion By similarity UniRule annotation

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 410Lipoyl synthase, mitochondrialUniRule annotationPRO_0000398229
Transit peptidei1 – ?Mitochondrion Reviewed prediction

Structurei

3D structure databases

ProteinModelPortaliC4PZQ3.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000235998.
KOiK03644.
OMAiPEEPYNT.
PhylomeDBiC4PZQ3.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00206. Lipoyl_synth.
InterProiIPR013785. Aldolase_TIM.
IPR006638. Elp3/MiaB/NifB.
IPR003698. Lipoyl_synth.
IPR007197. rSAM.
[Graphical view]
PANTHERiPTHR10949. PTHR10949. 1 hit.
PfamiPF04055. Radical_SAM. 1 hit.
[Graphical view]
PIRSFiPIRSF005963. Lipoyl_synth. 1 hit.
SMARTiSM00729. Elp3. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00510. lipA. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C4PZQ3-1 [UniParc]FASTAAdd to Basket

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MGLLLPRGSY VFPVLASVSA ATKRRAEWSY IKINITHSYS SNDKSSEFEE    50
DNPTQKLSPE FQKAIAHGPS LSEFIKLSNN NQSTKEDFFS SPSSVNKSGK 100
SLRLPEWLKT EIPCGGSVAR LQKQLRSLNL HTVCEEARCP NISECWTAGK 150
STAATATIMI MGDTCTRGCR FCSVKTSPNP PPLDPDEPVN TAEAISKWDV 200
DYIVITSVDR DDLGDGGARH IAKTIRQIKV RKPSIIVECL VPDFRGCTDS 250
IHTVVRASPE VYAHNIETVE SLQRVVRDHR AGYIQSLRSL ETAKERSNRL 300
VSSGDADFLV VTKSSIMLGL GEKEKEVMIA LKDLRQAGVD CVTIGQYVQP 350
TKRHLKVKEY IHPDKFDYWA KIGNDLGFLY TASGPLVRSS YRAGEYYIKH 400
IIDQRKRKNI 410
Length:410
Mass (Da):45,769
Last modified:July 7, 2009 - v1
Checksum:i727583BC7ADF758F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE601626 Genomic DNA. Translation: CCD78443.1.
UniGeneiSma.3820.

Genome annotation databases

EnsemblMetazoaiSmp_010100.1; Smp_010100.1:pep; Smp_010100.
KEGGismm:Smp_010100.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE601626 Genomic DNA. Translation: CCD78443.1 .
UniGenei Sma.3820.

3D structure databases

ProteinModelPortali C4PZQ3.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai Smp_010100.1 ; Smp_010100.1:pep ; Smp_010100 .
KEGGi smm:Smp_010100.

Phylogenomic databases

HOGENOMi HOG000235998.
KOi K03644.
OMAi PEEPYNT.
PhylomeDBi C4PZQ3.

Enzyme and pathway databases

UniPathwayi UPA00538 ; UER00593 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00206. Lipoyl_synth.
InterProi IPR013785. Aldolase_TIM.
IPR006638. Elp3/MiaB/NifB.
IPR003698. Lipoyl_synth.
IPR007197. rSAM.
[Graphical view ]
PANTHERi PTHR10949. PTHR10949. 1 hit.
Pfami PF04055. Radical_SAM. 1 hit.
[Graphical view ]
PIRSFi PIRSF005963. Lipoyl_synth. 1 hit.
SMARTi SM00729. Elp3. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00510. lipA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome of the blood fluke Schistosoma mansoni."
    Berriman M., Haas B.J., LoVerde P.T., Wilson R.A., Dillon G.P., Cerqueira G.C., Mashiyama S.T., Al-Lazikani B., Andrade L.F., Ashton P.D., Aslett M.A., Bartholomeu D.C., Blandin G., Caffrey C.R., Coghlan A., Coulson R., Day T.A., Delcher A.
    , DeMarco R., Djikeng A., Eyre T., Gamble J.A., Ghedin E., Gu Y., Hertz-Fowler C., Hirai H., Hirai Y., Houston R., Ivens A., Johnston D.A., Lacerda D., Macedo C.D., McVeigh P., Ning Z., Oliveira G., Overington J.P., Parkhill J., Pertea M., Pierce R.J., Protasio A.V., Quail M.A., Rajandream M.A., Rogers J., Sajid M., Salzberg S.L., Stanke M., Tivey A.R., White O., Williams D.L., Wortman J., Wu W., Zamanian M., Zerlotini A., Fraser-Liggett C.M., Barrell B.G., El-Sayed N.M.
    Nature 460:352-358(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Puerto Rican.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Puerto Rican.

Entry informationi

Entry nameiLIAS_SCHMA
AccessioniPrimary (citable) accession number: C4PZQ3
Secondary accession number(s): G4VET5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: July 7, 2009
Last modified: September 3, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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