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C4PRB0

- C4PRB0_CHLTJ

UniProt

C4PRB0 - C4PRB0_CHLTJ

Protein

Serine hydroxymethyltransferase

Gene

glyA

Organism
Chlamydia trachomatis serovar B (strain Jali20/OT)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (07 Jul 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.UniRule annotation

    Catalytic activityi

    5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei59 – 591Pyridoxal phosphateUniRule annotation
    Binding sitei79 – 791Pyridoxal phosphateUniRule annotation
    Binding sitei81 – 811SubstrateUniRule annotation
    Binding sitei88 – 881SubstrateUniRule annotation
    Binding sitei89 – 891Pyridoxal phosphateUniRule annotation
    Binding sitei176 – 1761Substrate; via carbonyl oxygenUniRule annotation
    Binding sitei232 – 2321Pyridoxal phosphateUniRule annotation
    Binding sitei260 – 2601Pyridoxal phosphateUniRule annotation
    Binding sitei288 – 2881Pyridoxal phosphateUniRule annotation
    Binding sitei295 – 2951Pyridoxal phosphateUniRule annotation
    Binding sitei319 – 3191Pyridoxal phosphate; via amide nitrogen and carbonyl oxygenUniRule annotation
    Binding sitei419 – 4191Pyridoxal phosphateUniRule annotation

    GO - Molecular functioni

    1. glycine hydroxymethyltransferase activity Source: UniProtKB-HAMAP
    2. methyltransferase activity Source: UniProtKB-KW
    3. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glycine biosynthetic process from serine Source: UniProtKB-HAMAP
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    MethyltransferaseImported, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesisUniRule annotation, One-carbon metabolismUniRule annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotation

    Enzyme and pathway databases

    BioCyciCTRA580049:GH1T-458-MONOMER.
    UniPathwayiUPA00193.
    UPA00288; UER01023.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine hydroxymethyltransferaseUniRule annotation (EC:2.1.2.1UniRule annotation)
    Short name:
    SHMTUniRule annotation
    Short name:
    Serine methylaseUniRule annotation
    Gene namesi
    Name:glyAUniRule annotationImported
    Ordered Locus Names:JALI_4331Imported
    OrganismiChlamydia trachomatis serovar B (strain Jali20/OT)Imported
    Taxonomic identifieri580049 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
    ProteomesiUP000002053: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei289 – 2891N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi580049.JALI_4331.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SHMT family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0112.
    HOGENOMiHOG000239404.
    KOiK00600.
    OMAiHLMLVDV.
    OrthoDBiEOG6Z0QB2.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    3.90.1150.10. 1 hit.
    HAMAPiMF_00051. SHMT.
    InterProiIPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    IPR001085. Ser_HO-MeTrfase.
    IPR019798. Ser_HO-MeTrfase_PLP_BS.
    [Graphical view]
    PANTHERiPTHR11680. PTHR11680. 1 hit.
    PfamiPF00464. SHMT. 2 hits.
    [Graphical view]
    PIRSFiPIRSF000412. SHMT. 1 hit.
    SUPFAMiSSF53383. SSF53383. 2 hits.
    PROSITEiPS00096. SHMT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C4PRB0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASLLDRYLR NISDKSQQNL ASVAYSASLD HLLHAFPSIG QSIVQELKSQ    50
    RSRLKMIASE NFSSLSVQLA MGNLLTDKYC EGSPFKRFYS CCENVDAIEW 100
    ECAETAKELF GAESAFVQPH SGADANLLAI MSIITQKIQS PAVQRLGYKT 150
    INDLPEQEYE ALKAEMAQHK CLGPSLNSGG HLTHGTVRMN IMSKLMHCLP 200
    YEVNLDTELF DYDEIAKIAK EHKPTVLIAG YSSYSRRLNF ATLKQIAEDC 250
    GAVLWVDMAH FAGLVAGGVF VGEENPMPYA DIVTTTTHKT LRGPRGGLVL 300
    AKKEYANTLN KACPLMMGGP LPHVIAAKAI ALKEAMTINF RKYAHKVVEN 350
    ARTLAEVFQR NGLRLLTGGT DNHMLIIDLT SLGVPGRIAE DMLTSVGIAV 400
    NRNTIPSDAS GQWKTSGIRL GTPALTTLGM GSAEMEEVAN IIVKVLRNIT 450
    VRSNAESGSS KSEGELSEGI AQEARQRVAD LLGRFPLYPE IDLETLV 497
    Length:497
    Mass (Da):54,245
    Last modified:July 7, 2009 - v1
    Checksum:i73663EF9F07AA11F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM872308 Genomic DNA. Translation: CAX10887.1.
    RefSeqiYP_002888053.1. NC_012686.1.

    Genome annotation databases

    EnsemblBacteriaiCAX10887; CAX10887; JALI_4331.
    GeneIDi7882273.
    KEGGictj:JALI_4331.
    PATRICi20378430. VBIChlTra100303_0488.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM872308 Genomic DNA. Translation: CAX10887.1 .
    RefSeqi YP_002888053.1. NC_012686.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 580049.JALI_4331.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAX10887 ; CAX10887 ; JALI_4331 .
    GeneIDi 7882273.
    KEGGi ctj:JALI_4331.
    PATRICi 20378430. VBIChlTra100303_0488.

    Phylogenomic databases

    eggNOGi COG0112.
    HOGENOMi HOG000239404.
    KOi K00600.
    OMAi HLMLVDV.
    OrthoDBi EOG6Z0QB2.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    UPA00288 ; UER01023 .
    BioCyci CTRA580049:GH1T-458-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    3.90.1150.10. 1 hit.
    HAMAPi MF_00051. SHMT.
    InterProi IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    IPR001085. Ser_HO-MeTrfase.
    IPR019798. Ser_HO-MeTrfase_PLP_BS.
    [Graphical view ]
    PANTHERi PTHR11680. PTHR11680. 1 hit.
    Pfami PF00464. SHMT. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF000412. SHMT. 1 hit.
    SUPFAMi SSF53383. SSF53383. 2 hits.
    PROSITEi PS00096. SHMT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Jali20/OTImported.

    Entry informationi

    Entry nameiC4PRB0_CHLTJ
    AccessioniPrimary (citable) accession number: C4PRB0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 7, 2009
    Last sequence update: July 7, 2009
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3