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C4PR05 (C4PR05_CHLTJ) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 19. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
1-deoxy-D-xylulose-5-phosphate synthase HAMAP MF_00315
EC=2.2.1.7 HAMAP MF_00315
Alternative name(s):
1-deoxyxylulose-5-phosphate synthase HAMAP MF_00315
Gene names
Name:dxs HAMAP MF_00315 EMBL CAX10782.1
Ordered Locus Names:JALI_3281
OrganismChlamydia trachomatis serovar B (strain Jali20/OT) [Complete proteome] [HAMAP]
Taxonomic identifier580049 [NCBI]
Taxonomic lineageBacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydia

Protein attributes

Sequence length640 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) By similarity. HAMAP MF_00315 SAAS SAAS005477

Catalytic activity

Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. HAMAP MF_00315 SAAS SAAS005477

Cofactor

Binds 1 thiamine pyrophosphate per subunit By similarity. HAMAP MF_00315 SAAS SAAS005477

Pathway

Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1. HAMAP MF_00315 SAAS SAAS005477

Subunit structure

Homodimer By similarity. HAMAP MF_00315 SAAS SAAS005477

Sequence similarities

Belongs to the transketolase family. DXPS subfamily. HAMAP MF_00315

Sequences

Sequence LengthMass (Da)Tools
C4PR05 [UniParc].

Last modified November 3, 2009. Version 1.
Checksum: 0D45A1CBA81F66D1

FASTA64070,786
        10         20         30         40         50         60 
MTYSLLPHIH SPQDLHALSL DKLPVLCDEI RNKIIESLSL TGGHLASNLG GVELTVALHY 

        70         80         90        100        110        120 
VFSSPDDQFI FDVGHQSYVH KLLTGRNTEA FSNIRHDNGL SGFTTPQESN HDIFFSGHAG 

       130        140        150        160        170        180 
NALSLALGLA KGSSNSSSHI LPILGDAAFS CGLTLEALNN IPADLSKFII VLNDNQMSIS 

       190        200        210        220        230        240 
ENVGNIPQGI SHWMYPQKIS KLSQKIHSWI QNLPSFLHKK KTLSHKVDIA LKSLSHPLFE 

       250        260        270        280        290        300 
QFGLHYVGPI DGHNVKKLVQ ALQMIKDQPQ PILFHVCTVK GNGLAEAERD PIRYHGVKAH 

       310        320        330        340        350        360 
FQNTSLKKTS GNVELQTPIS FPQHAGNILC RLGKKYPQLQ VVTPAMSLGS CLEDFRKQFP 

       370        380        390        400        410        420 
DRFTDVGIAE GHAVTFSAGI ARSGTPVCCS IYSTFLHRAM DNVFHDVCMQ ELPVIFAIDR 

       430        440        450        460        470        480 
AGLAFHDGRS HHGIYDLGFL CSMPNMVICQ PRNALVLERL FFSSLLWKSP CAIRYPNIPA 

       490        500        510        520        530        540 
NEKASNSFFP FSPILPGEAE ILCQGDDLLL IALGHMCNTA LTVKEHLLDY GISTTVVDPI 

       550        560        570        580        590        600 
FIKPLDRKLL QSLLTHHSKV IILEEHSIHG GLGSEFLLFL NQHNIKADVL SLGVPDMFIP 

       610        620        630        640 
HGNPETILNL IGLTSDHITQ RILSHFKFFT PIPIERFFKA

« Hide

References

[1]"Co-evolution of genomes and plasmids within Chlamydia trachomatis and the emergence in Sweden of a new variant strain."
Seth-Smith H.M.B., Harris S.R., Persson K., Marsh P., Barron A., Bignell A., Bjartling C., Clark L., Cutcliffe L.T., Lambden P.R., Lennard N., Lockey S.J., Quail M.A., Salim O., Skilton R.J., Wang Y., Holland M.J., Parkhill J., Thomson N.R., Clarke I.N.
BMC Genomics 10:239-239(2009) [PubMed: 19460133] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FM872308 Genomic DNA. Translation: CAX10782.1.
RefSeqYP_002887949.1. NC_012686.1.

3D structure databases

ProteinModelPortalC4PR05.
ModBaseSearch...

Protein-protein interaction databases

STRINGC4PR05.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7881591.
GenomeReviewsGene locus JALI_3281 in contig FM872308_GR.
KEGGctj:JALI_3281.
PATRIC20378202. VBIChlTra100303_0377.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMAEAMNAHA.
ProtClustDBPRK05444.

Family and domain databases

HAMAPMF_00315. DXP_synth.
[Tree]
InterProIPR005477. Dxylulose-5-P_synthase.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR015941. Transketolase-like_C.
IPR005475. Transketolase-like_Pyr-bd.
IPR005476. Transketolase_C.
IPR005474. Transketolase_N.
[Graphical view]
Gene3DG3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KOK01662.
PfamPF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
[Graphical view]
SMARTSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMSSF52922. Transketo_C_like. 1 hit.
TIGRFAMsTIGR00204. Dxs. 1 hit.
PROSITEPS00801. TRANSKETOLASE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC4PR05_CHLTJ
AccessionPrimary (citable) accession number: C4PR05
Entry history
Integrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: January 25, 2012
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info