C4PQW4 (C4PQW4_CHLTJ) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase HAMAP MF_00116
Short name=dUTPase HAMAP MF_00116
EC=3.6.1.23 HAMAP MF_00116

Alternative name(s):
dUTP pyrophosphatase HAMAP MF_00116

Gene names

Name:	dut HAMAP MF_00116 EMBL CAX10741.1
Ordered Locus Names:	JALI_2871

Organism

Chlamydia trachomatis serovar B (strain Jali20/OT) [Complete proteome] [HAMAP]

Taxonomic identifier

580049 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydia

Protein attributes

Sequence length	145 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA By similarity. HAMAP MF_00116 SAAS SAAS008181
Catalytic activity	dUTP + H2O = dUMP + diphosphate. HAMAP MF_00116 SAAS SAAS008181
Cofactor	Magnesium By similarity. HAMAP MF_00116 SAAS SAAS008181
Pathway	Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2. HAMAP MF_00116
Sequence similarities	Belongs to the dUTPase family. HAMAP MF_00116

Ontologies

Keywords
Biological process	Nucleotide metabolism HAMAP MF_00116 SAAS SAAS008181
Ligand	Magnesium HAMAP MF_00116 SAAS SAAS008181 Metal-binding HAMAP MF_00116 SAAS SAAS008181
Molecular function	Hydrolase HAMAP MF_00116 SAAS SAAS008181 EMBL CAX10741.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	dUTP metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	dUTP diphosphatase activity Inferred from electronic annotation. Source: HAMAP magnesium ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Region	63 – 65	3	Substrate binding By similarity HAMAP MF_00116
	Region	80 – 82	3	Substrate binding By similarity HAMAP MF_00116
Sites
	Binding site	76	1	Substrate By similarity HAMAP MF_00116

Sequences

	Sequence		Length	Mass (Da)
	C4PQW4 [UniParc]. Last modified July 7, 2009. Version 1. Checksum: FC46D737ACBF6830	FASTA	145	15,351
	10 20 30 40 50 60 MKFFCKLESG SSLPEYATSG ASGADVRANI NEPIAILPGQ RALIPTGISV EIPHGYEIQV 70 80 90 100 110 120 RSRSGLASKY GVIVLQSPGT VDADYRGEIR VILANLGEAT FIVEPGMRIA QLVIAKVEQV 130 140 SFVETQEELT ATARGTGGFG HTGEC

References

[1]

"Co-evolution of genomes and plasmids within Chlamydia trachomatis and the emergence in Sweden of a new variant strain." Seth-Smith H.M.B., Harris S.R., Persson K., Marsh P., Barron A., Bignell A., Bjartling C., Clark L., Cutcliffe L.T., Lambden P.R., Lennard N., Lockey S.J., Quail M.A., Salim O., Skilton R.J., Wang Y., Holland M.J., Parkhill J., Thomson N.R., Clarke I.N. BMC Genomics 10:239-239(2009) [PubMed: 19460133] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	FM872308 Genomic DNA. Translation: CAX10741.1.
RefSeq	YP_002887909.1. NC_012686.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	C4PQW4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7881674.
GenomeReviews	Gene locus JALI_2871 in contig FM872308_GR.
KEGG	ctj:JALI_2871.
PATRIC	20378108. VBIChlTra100303_0333.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	LDLRACI.
ProtClustDB	PRK00601.
Family and domain databases
HAMAP	MF_00116. dUTPase_bact. [Tree]
InterPro	IPR008180. dUTP_pyroPase. IPR008181. dUTP_pyroPase_sf. [Graphical view]
KO	K01520.
PANTHER	PTHR11241. PTHR11241. 1 hit.
Pfam	PF00692. dUTPase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00576. Dut. 1 hit.
ProtoNet	Search...

Entry information

Entry name

C4PQW4_CHLTJ

Accession

Primary (citable) accession number: C4PQW4

Entry history

Integrated into UniProtKB/TrEMBL:	July 7, 2009
Last sequence update:	July 7, 2009
Last modified:	January 25, 2012
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)