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C4PQT7 (C4PQT7_CHLTJ) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 21. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha HAMAP MF_00823
Short name=ACCase subunit alpha HAMAP MF_00823
Short name=Acetyl-CoA carboxylase carboxyltransferase subunit alpha HAMAP MF_00823
EC=6.4.1.2 HAMAP MF_00823
Gene names
Name:accA HAMAP MF_00823 EMBL CAX10714.1
Ordered Locus Names:JALI_2601
OrganismChlamydia trachomatis serovar B (strain Jali20/OT) [Complete proteome] [HAMAP]
Taxonomic identifier580049 [NCBI]
Taxonomic lineageBacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydia

Protein attributes

Sequence length324 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO2 group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA By similarity. HAMAP MF_00823 SAAS SAAS011763

Catalytic activity

ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA. HAMAP MF_00823 SAAS SAAS011763

Pathway

Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. HAMAP MF_00823 SAAS SAAS011763

Subunit structure

Acetyl-CoA carboxylase is an heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD) By similarity. HAMAP MF_00823 SAAS SAAS011763

Subcellular location

Cytoplasm By similarity HAMAP MF_00823 SAAS SAAS011763.

Sequence similarities

Belongs to the AccA family. HAMAP MF_00823

Sequences

Sequence LengthMass (Da)Tools
C4PQT7 [UniParc].

Last modified July 7, 2009. Version 1.
Checksum: F3859A16CA8904A9

FASTA32436,332
        10         20         30         40         50         60 
MELLPHEKQV VEYEKAIAEF KEKNKENSLL SSSEIQKLDK RLDRLKEKIY SDLTPWERVQ 

        70         80         90        100        110        120 
ICRHPSRPRT VNYIEGMCEE FVELCGDRTF RDDPAVVGGF AKIQGQRFML IGQEKGCDTK 

       130        140        150        160        170        180 
SRMHRNFGML CPEGFRKALR LAKMAEKFGL PIIFLVDTPG AFPGLTAEER GQGWAIATNL 

       190        200        210        220        230        240 
FELARLATPI IVIVIGEGCS GGALGMAIGD VVAMLEHSYY SVISPEGCAS ILWKDPKKNS 

       250        260        270        280        290        300 
DAAAMLKMHG EDLKGFAIVD AVIKEPIGGA HHNPAATYRS VQEHVLQEWL KLKDLPVEEL 

       310        320 
LEKRYQKFRT IGLYETSSES DSEA

« Hide

References

[1]"Co-evolution of genomes and plasmids within Chlamydia trachomatis and the emergence in Sweden of a new variant strain."
Seth-Smith H.M.B., Harris S.R., Persson K., Marsh P., Barron A., Bignell A., Bjartling C., Clark L., Cutcliffe L.T., Lambden P.R., Lennard N., Lockey S.J., Quail M.A., Salim O., Skilton R.J., Wang Y., Holland M.J., Parkhill J., Thomson N.R., Clarke I.N.
BMC Genomics 10:239-239(2009) [PubMed: 19460133] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FM872308 Genomic DNA. Translation: CAX10714.1.
RefSeqYP_002887882.1. NC_012686.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGC4PQT7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7881569.
GenomeReviewsGene locus JALI_2601 in contig FM872308_GR.
KEGGctj:JALI_2601.
PATRIC20378050. VBIChlTra100303_0304.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMAGRDTKDN.
ProtClustDBPRK05724.

Family and domain databases

HAMAPMF_00823. AcetylCoA_CT_alpha.
[Tree]
InterProIPR001095. Acetyl_CoA_COase_a_su.
IPR011763. COA_CT_C.
[Graphical view]
KOK01962.
PANTHERPTHR22855:SF3. Ac-CoA_carboxylA. 1 hit.
PfamPF03255. ACCA. 1 hit.
[Graphical view]
PRINTSPR01069. ACCCTRFRASEA.
TIGRFAMsTIGR00513. AccA. 1 hit.
PROSITEPS50989. COA_CT_CTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC4PQT7_CHLTJ
AccessionPrimary (citable) accession number: C4PQT7
Entry history
Integrated into UniProtKB/TrEMBL: July 7, 2009
Last sequence update: July 7, 2009
Last modified: January 25, 2012
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info