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C4PQR9

- C4PQR9_CHLTJ

UniProt

C4PQR9 - C4PQR9_CHLTJ

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Protein

Acetyltransferase component of pyruvate dehydrogenase complex

Gene

pdhC

Organism
Chlamydia trachomatis serovar B (strain Jali20/OT)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

Catalytic activityi

Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine.UniRule annotation

Cofactori

Binds 1 lipoyl cofactor covalently.UniRule annotation
Binds 2 lipoyl cofactors covalently.UniRule annotation
Binds 3 lipoyl cofactors covalently.UniRule annotation

GO - Molecular functioni

  1. dihydrolipoyllysine-residue acetyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. pyruvate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseUniRule annotation, Transferase

Keywords - Ligandi

PyruvateImported

Enzyme and pathway databases

BioCyciCTRA580049:GH1T-261-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
Gene namesi
Name:pdhCImported
Ordered Locus Names:JALI_2421Imported
OrganismiChlamydia trachomatis serovar B (strain Jali20/OT)Imported
Taxonomic identifieri580049 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000002053: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. pyruvate dehydrogenase complex Source: InterPro
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi580049.JALI_2421.

Structurei

3D structure databases

ProteinModelPortaliC4PQR9.
SMRiC4PQR9. Positions 7-66.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation
Contains 1 lipoyl-binding domain.UniRule annotation

Keywords - Domaini

LipoylUniRule annotation

Phylogenomic databases

eggNOGiCOG0508.
HOGENOMiHOG000281566.
KOiK00627.
OMAiPISNIRK.
OrthoDBiEOG610413.

Family and domain databases

Gene3Di3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProiIPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR006257. LAT1.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02817. E3_binding. 1 hit.
[Graphical view]
SUPFAMiSSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 1 hit.
TIGRFAMsiTIGR01349. PDHac_trf_mito. 1 hit.
PROSITEiPS50968. BIOTINYL_LIPOYL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C4PQR9 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVSLLKMPKL SPTMEIGILV KWHKKAGDEI HFGDVLLEIS TDKAVLEHTA
60 70 80 90 100
SEDGWLLEIL VEEGTKTPIG TPIAVFSTEQ NAQYDLKQLL PLEGTVVTDA
110 120 130 140 150
ATEASPKNSA QTDSQYTSGP SITMMGFRPE PPLAIPLTIK HSNDPVLASP
160 170 180 190 200
LAKKLAKEQN LDLSGVTGSG PGGRIVKKDL EKAPPLRIAG FGYPEAPNVN
210 220 230 240 250
PGSYIEEPLS PVREVISKRL QAAKTFIPHF YVRQRIYASP LLALLKELQE
260 270 280 290 300
QNIKLSINDC IVRACALALK EFPEINSGFN SVDNKIIRFS TIDISIAVAI
310 320 330 340 350
PDGVITPIVR CADRKNIGMI SAEIKGLATK AKQQSLAEEE YKGGSFCVSN
360 370 380 390 400
LGMTGISDFT AILNPPQAAI LAVGSVEEQP VVLNGELAVG LTCMLTLSVD
410 420
HRVIDGYPAA MFMKRLQRLL EAPSVLLLN
Length:429
Mass (Da):46,352
Last modified:November 3, 2009 - v1
Checksum:i1D6FA66A67E41180
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM872308 Genomic DNA. Translation: CAX10696.1.
RefSeqiYP_002887864.1. NC_012686.1.

Genome annotation databases

EnsemblBacteriaiCAX10696; CAX10696; JALI_2421.
GeneIDi7881633.
KEGGictj:JALI_2421.
PATRICi20378012. VBIChlTra100303_0285.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM872308 Genomic DNA. Translation: CAX10696.1 .
RefSeqi YP_002887864.1. NC_012686.1.

3D structure databases

ProteinModelPortali C4PQR9.
SMRi C4PQR9. Positions 7-66.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 580049.JALI_2421.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAX10696 ; CAX10696 ; JALI_2421 .
GeneIDi 7881633.
KEGGi ctj:JALI_2421.
PATRICi 20378012. VBIChlTra100303_0285.

Phylogenomic databases

eggNOGi COG0508.
HOGENOMi HOG000281566.
KOi K00627.
OMAi PISNIRK.
OrthoDBi EOG610413.

Enzyme and pathway databases

BioCyci CTRA580049:GH1T-261-MONOMER.

Family and domain databases

Gene3Di 3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProi IPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR006257. LAT1.
IPR011053. Single_hybrid_motif.
[Graphical view ]
Pfami PF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02817. E3_binding. 1 hit.
[Graphical view ]
SUPFAMi SSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 1 hit.
TIGRFAMsi TIGR01349. PDHac_trf_mito. 1 hit.
PROSITEi PS50968. BIOTINYL_LIPOYL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Jali20/OTImported.

Entry informationi

Entry nameiC4PQR9_CHLTJ
AccessioniPrimary (citable) accession number: C4PQR9
Entry historyi
Integrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: October 1, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3