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C4PQR9 (C4PQR9_CHLTJ) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Acetyltransferase component of pyruvate dehydrogenase complex RuleBase RU361137

EC=2.3.1.12 RuleBase RU361137
Gene names
Name:pdhC EMBL CAX10696.1
Ordered Locus Names:JALI_2421 EMBL CAX10696.1
OrganismChlamydia trachomatis serovar B (strain Jali20/OT) [Complete proteome] [HAMAP] EMBL CAX10696.1
Taxonomic identifier580049 [NCBI]
Taxonomic lineageBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia

Protein attributes

Sequence length429 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2 By similarity. RuleBase RU361137

Catalytic activity

Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine. RuleBase RU361137

Cofactor

Binds 1 lipoyl cofactor covalently By similarity. RuleBase RU361137

Binds 2 lipoyl cofactors covalently By similarity. RuleBase RU361137

Binds 3 lipoyl cofactors covalently By similarity. RuleBase RU361137

Sequence similarities

Belongs to the 2-oxoacid dehydrogenase family. RuleBase RU361137

Contains 1 lipoyl-binding domain. RuleBase RU361137

Ontologies

Sequences

Sequence LengthMass (Da)Tools
C4PQR9 [UniParc].

Last modified November 3, 2009. Version 1.
Checksum: 1D6FA66A67E41180

FASTA42946,352
        10         20         30         40         50         60 
MVSLLKMPKL SPTMEIGILV KWHKKAGDEI HFGDVLLEIS TDKAVLEHTA SEDGWLLEIL 

        70         80         90        100        110        120 
VEEGTKTPIG TPIAVFSTEQ NAQYDLKQLL PLEGTVVTDA ATEASPKNSA QTDSQYTSGP 

       130        140        150        160        170        180 
SITMMGFRPE PPLAIPLTIK HSNDPVLASP LAKKLAKEQN LDLSGVTGSG PGGRIVKKDL 

       190        200        210        220        230        240 
EKAPPLRIAG FGYPEAPNVN PGSYIEEPLS PVREVISKRL QAAKTFIPHF YVRQRIYASP 

       250        260        270        280        290        300 
LLALLKELQE QNIKLSINDC IVRACALALK EFPEINSGFN SVDNKIIRFS TIDISIAVAI 

       310        320        330        340        350        360 
PDGVITPIVR CADRKNIGMI SAEIKGLATK AKQQSLAEEE YKGGSFCVSN LGMTGISDFT 

       370        380        390        400        410        420 
AILNPPQAAI LAVGSVEEQP VVLNGELAVG LTCMLTLSVD HRVIDGYPAA MFMKRLQRLL 


EAPSVLLLN 

« Hide

References

[1]"Co-evolution of genomes and plasmids within Chlamydia trachomatis and the emergence in Sweden of a new variant strain."
Seth-Smith H.M.B., Harris S.R., Persson K., Marsh P., Barron A., Bignell A., Bjartling C., Clark L., Cutcliffe L.T., Lambden P.R., Lennard N., Lockey S.J., Quail M.A., Salim O., Skilton R.J., Wang Y., Holland M.J., Parkhill J., Thomson N.R., Clarke I.N.
BMC Genomics 10:239-239(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Jali20/OT.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FM872308 Genomic DNA. Translation: CAX10696.1.
RefSeqYP_002887864.1. NC_012686.1.

3D structure databases

ProteinModelPortalC4PQR9.
SMRC4PQR9. Positions 7-66.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING580049.JALI_2421.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAX10696; CAX10696; JALI_2421.
GeneID7881633.
KEGGctj:JALI_2421.
PATRIC20378012. VBIChlTra100303_0285.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0508.
HOGENOMHOG000281566.
KOK00627.
OMAPISNIRK.
OrthoDBEOG610413.

Enzyme and pathway databases

BioCycCTRA580049:GH1T-261-MONOMER.

Family and domain databases

Gene3D3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProIPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR006257. LAT1.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamPF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02817. E3_binding. 1 hit.
[Graphical view]
SUPFAMSSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 1 hit.
TIGRFAMsTIGR01349. PDHac_trf_mito. 1 hit.
PROSITEPS50968. BIOTINYL_LIPOYL. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC4PQR9_CHLTJ
AccessionPrimary (citable) accession number: C4PQR9
Entry history
Integrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: July 9, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)