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C4PQR9

- C4PQR9_CHLTJ

UniProt

C4PQR9 - C4PQR9_CHLTJ

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Protein

Acetyltransferase component of pyruvate dehydrogenase complex

Gene
pdhC, JALI_2421
Organism
Chlamydia trachomatis serovar B (strain Jali20/OT)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2 By similarity.UniRule annotation

Catalytic activityi

Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine.UniRule annotation

Cofactori

Binds 1 lipoyl cofactor covalently By similarity.UniRule annotation
Binds 2 lipoyl cofactors covalently By similarity.UniRule annotation
Binds 3 lipoyl cofactors covalently By similarity.UniRule annotation

GO - Molecular functioni

  1. dihydrolipoyllysine-residue acetyltransferase activity Source: InterPro

GO - Biological processi

  1. pyruvate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseUniRule annotation, Transferase

Keywords - Ligandi

PyruvateImported

Enzyme and pathway databases

BioCyciCTRA580049:GH1T-261-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
Gene namesi
Name:pdhCImported
Ordered Locus Names:JALI_2421Imported
OrganismiChlamydia trachomatis serovar B (strain Jali20/OT)Imported
Taxonomic identifieri580049 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000002053: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. pyruvate dehydrogenase complex Source: InterPro
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi580049.JALI_2421.

Structurei

3D structure databases

ProteinModelPortaliC4PQR9.
SMRiC4PQR9. Positions 7-66.

Family & Domainsi

Sequence similaritiesi

Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation
Contains 1 lipoyl-binding domain.UniRule annotation

Keywords - Domaini

LipoylUniRule annotation

Phylogenomic databases

eggNOGiCOG0508.
HOGENOMiHOG000281566.
KOiK00627.
OMAiPISNIRK.
OrthoDBiEOG610413.

Family and domain databases

Gene3Di3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProiIPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR006257. LAT1.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02817. E3_binding. 1 hit.
[Graphical view]
SUPFAMiSSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 1 hit.
TIGRFAMsiTIGR01349. PDHac_trf_mito. 1 hit.
PROSITEiPS50968. BIOTINYL_LIPOYL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C4PQR9-1 [UniParc]FASTAAdd to Basket

« Hide

MVSLLKMPKL SPTMEIGILV KWHKKAGDEI HFGDVLLEIS TDKAVLEHTA    50
SEDGWLLEIL VEEGTKTPIG TPIAVFSTEQ NAQYDLKQLL PLEGTVVTDA 100
ATEASPKNSA QTDSQYTSGP SITMMGFRPE PPLAIPLTIK HSNDPVLASP 150
LAKKLAKEQN LDLSGVTGSG PGGRIVKKDL EKAPPLRIAG FGYPEAPNVN 200
PGSYIEEPLS PVREVISKRL QAAKTFIPHF YVRQRIYASP LLALLKELQE 250
QNIKLSINDC IVRACALALK EFPEINSGFN SVDNKIIRFS TIDISIAVAI 300
PDGVITPIVR CADRKNIGMI SAEIKGLATK AKQQSLAEEE YKGGSFCVSN 350
LGMTGISDFT AILNPPQAAI LAVGSVEEQP VVLNGELAVG LTCMLTLSVD 400
HRVIDGYPAA MFMKRLQRLL EAPSVLLLN 429
Length:429
Mass (Da):46,352
Last modified:November 3, 2009 - v1
Checksum:i1D6FA66A67E41180
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM872308 Genomic DNA. Translation: CAX10696.1.
RefSeqiYP_002887864.1. NC_012686.1.

Genome annotation databases

EnsemblBacteriaiCAX10696; CAX10696; JALI_2421.
GeneIDi7881633.
KEGGictj:JALI_2421.
PATRICi20378012. VBIChlTra100303_0285.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM872308 Genomic DNA. Translation: CAX10696.1 .
RefSeqi YP_002887864.1. NC_012686.1.

3D structure databases

ProteinModelPortali C4PQR9.
SMRi C4PQR9. Positions 7-66.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 580049.JALI_2421.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAX10696 ; CAX10696 ; JALI_2421 .
GeneIDi 7881633.
KEGGi ctj:JALI_2421.
PATRICi 20378012. VBIChlTra100303_0285.

Phylogenomic databases

eggNOGi COG0508.
HOGENOMi HOG000281566.
KOi K00627.
OMAi PISNIRK.
OrthoDBi EOG610413.

Enzyme and pathway databases

BioCyci CTRA580049:GH1T-261-MONOMER.

Family and domain databases

Gene3Di 3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProi IPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR006257. LAT1.
IPR011053. Single_hybrid_motif.
[Graphical view ]
Pfami PF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02817. E3_binding. 1 hit.
[Graphical view ]
SUPFAMi SSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 1 hit.
TIGRFAMsi TIGR01349. PDHac_trf_mito. 1 hit.
PROSITEi PS50968. BIOTINYL_LIPOYL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Jali20/OT.

Entry informationi

Entry nameiC4PQR9_CHLTJ
AccessioniPrimary (citable) accession number: C4PQR9
Entry historyi
Integrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: July 9, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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