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C4PQR9

- C4PQR9_CHLTJ

UniProt

C4PQR9 - C4PQR9_CHLTJ

Protein

Acetyltransferase component of pyruvate dehydrogenase complex

Gene

pdhC

Organism
Chlamydia trachomatis serovar B (strain Jali20/OT)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (03 Nov 2009)
      Previous versions | rss
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    Functioni

    The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

    Catalytic activityi

    Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine.UniRule annotation

    Cofactori

    Binds 1 lipoyl cofactor covalently.UniRule annotation
    Binds 2 lipoyl cofactors covalently.UniRule annotation
    Binds 3 lipoyl cofactors covalently.UniRule annotation

    GO - Molecular functioni

    1. dihydrolipoyllysine-residue acetyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. pyruvate metabolic process Source: InterPro

    Keywords - Molecular functioni

    AcyltransferaseUniRule annotation, Transferase

    Keywords - Ligandi

    PyruvateImported

    Enzyme and pathway databases

    BioCyciCTRA580049:GH1T-261-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
    Gene namesi
    Name:pdhCImported
    Ordered Locus Names:JALI_2421Imported
    OrganismiChlamydia trachomatis serovar B (strain Jali20/OT)Imported
    Taxonomic identifieri580049 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
    ProteomesiUP000002053: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. pyruvate dehydrogenase complex Source: InterPro

    Interactioni

    Protein-protein interaction databases

    STRINGi580049.JALI_2421.

    Structurei

    3D structure databases

    ProteinModelPortaliC4PQR9.
    SMRiC4PQR9. Positions 7-66.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation
    Contains 1 lipoyl-binding domain.UniRule annotation

    Keywords - Domaini

    LipoylUniRule annotation

    Phylogenomic databases

    eggNOGiCOG0508.
    HOGENOMiHOG000281566.
    KOiK00627.
    OMAiPISNIRK.
    OrthoDBiEOG610413.

    Family and domain databases

    Gene3Di3.30.559.10. 1 hit.
    4.10.320.10. 1 hit.
    InterProiIPR001078. 2-oxoacid_DH_actylTfrase.
    IPR000089. Biotin_lipoyl.
    IPR023213. CAT-like_dom.
    IPR004167. E3-bd.
    IPR006257. LAT1.
    IPR011053. Single_hybrid_motif.
    [Graphical view]
    PfamiPF00198. 2-oxoacid_dh. 1 hit.
    PF00364. Biotin_lipoyl. 1 hit.
    PF02817. E3_binding. 1 hit.
    [Graphical view]
    SUPFAMiSSF47005. SSF47005. 1 hit.
    SSF51230. SSF51230. 1 hit.
    TIGRFAMsiTIGR01349. PDHac_trf_mito. 1 hit.
    PROSITEiPS50968. BIOTINYL_LIPOYL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C4PQR9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVSLLKMPKL SPTMEIGILV KWHKKAGDEI HFGDVLLEIS TDKAVLEHTA    50
    SEDGWLLEIL VEEGTKTPIG TPIAVFSTEQ NAQYDLKQLL PLEGTVVTDA 100
    ATEASPKNSA QTDSQYTSGP SITMMGFRPE PPLAIPLTIK HSNDPVLASP 150
    LAKKLAKEQN LDLSGVTGSG PGGRIVKKDL EKAPPLRIAG FGYPEAPNVN 200
    PGSYIEEPLS PVREVISKRL QAAKTFIPHF YVRQRIYASP LLALLKELQE 250
    QNIKLSINDC IVRACALALK EFPEINSGFN SVDNKIIRFS TIDISIAVAI 300
    PDGVITPIVR CADRKNIGMI SAEIKGLATK AKQQSLAEEE YKGGSFCVSN 350
    LGMTGISDFT AILNPPQAAI LAVGSVEEQP VVLNGELAVG LTCMLTLSVD 400
    HRVIDGYPAA MFMKRLQRLL EAPSVLLLN 429
    Length:429
    Mass (Da):46,352
    Last modified:November 3, 2009 - v1
    Checksum:i1D6FA66A67E41180
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM872308 Genomic DNA. Translation: CAX10696.1.
    RefSeqiYP_002887864.1. NC_012686.1.

    Genome annotation databases

    EnsemblBacteriaiCAX10696; CAX10696; JALI_2421.
    GeneIDi7881633.
    KEGGictj:JALI_2421.
    PATRICi20378012. VBIChlTra100303_0285.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM872308 Genomic DNA. Translation: CAX10696.1 .
    RefSeqi YP_002887864.1. NC_012686.1.

    3D structure databases

    ProteinModelPortali C4PQR9.
    SMRi C4PQR9. Positions 7-66.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 580049.JALI_2421.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAX10696 ; CAX10696 ; JALI_2421 .
    GeneIDi 7881633.
    KEGGi ctj:JALI_2421.
    PATRICi 20378012. VBIChlTra100303_0285.

    Phylogenomic databases

    eggNOGi COG0508.
    HOGENOMi HOG000281566.
    KOi K00627.
    OMAi PISNIRK.
    OrthoDBi EOG610413.

    Enzyme and pathway databases

    BioCyci CTRA580049:GH1T-261-MONOMER.

    Family and domain databases

    Gene3Di 3.30.559.10. 1 hit.
    4.10.320.10. 1 hit.
    InterProi IPR001078. 2-oxoacid_DH_actylTfrase.
    IPR000089. Biotin_lipoyl.
    IPR023213. CAT-like_dom.
    IPR004167. E3-bd.
    IPR006257. LAT1.
    IPR011053. Single_hybrid_motif.
    [Graphical view ]
    Pfami PF00198. 2-oxoacid_dh. 1 hit.
    PF00364. Biotin_lipoyl. 1 hit.
    PF02817. E3_binding. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47005. SSF47005. 1 hit.
    SSF51230. SSF51230. 1 hit.
    TIGRFAMsi TIGR01349. PDHac_trf_mito. 1 hit.
    PROSITEi PS50968. BIOTINYL_LIPOYL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Jali20/OTImported.

    Entry informationi

    Entry nameiC4PQR9_CHLTJ
    AccessioniPrimary (citable) accession number: C4PQR9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 3, 2009
    Last sequence update: November 3, 2009
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3