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C4PNU3 (C4PNU3_CHLTZ) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Cysteine--tRNA ligase HAMAP-Rule MF_00041
EC=6.1.1.16 HAMAP-Rule MF_00041
Alternative name(s):
Cysteinyl-tRNA synthetase HAMAP-Rule MF_00041
Gene names
Name:cysS HAMAP-Rule MF_00041 EMBL CAX10348.1
Ordered Locus Names:CTB_7871 EMBL CAX10348.1
OrganismChlamydia trachomatis serovar B (strain TZ1A828/OT) [Complete proteome] [HAMAP] EMBL CAX10348.1
Taxonomic identifier672161 [NCBI]
Taxonomic lineageBacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydia ›

Protein attributes

Sequence length497 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys). HAMAP-Rule MF_00041 SAAS SAAS015273

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP-Rule MF_00041

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00041

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00041 SAAS SAAS015273.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family. HAMAP-Rule MF_00041

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Motif50 – 6011"HIGH" region By similarity HAMAP-Rule MF_00041
Motif290 – 2945"KMSKS" region By similarity HAMAP-Rule MF_00041

Sites

Metal binding481Zinc By similarity HAMAP-Rule MF_00041
Metal binding2331Zinc By similarity HAMAP-Rule MF_00041
Metal binding2581Zinc By similarity HAMAP-Rule MF_00041
Metal binding2621Zinc By similarity HAMAP-Rule MF_00041
Binding site2931ATP By similarity HAMAP-Rule MF_00041

Sequences

Sequence LengthMass (Da)Tools
C4PNU3 [UniParc].

Last modified July 7, 2009. Version 1.
Checksum: F9D633171A964339

FASTA49757,210
        10         20         30         40         50         60 
MKGWIRSNST KTRPFRMNTA MDLFLYNTLS REKERFLPVN DPVKLYTCGP TVYDYAHIGN 

        70         80         90        100        110        120 
FRTYIFEDLL KRVLLFLGYS VYHVMNITDV DDKTLAGARK KGCSLEKYCQ PYIHAFFADL 

       130        140        150        160        170        180 
ETLHILKADA YPHATHYIPQ MIEAIQQLIN QGVAYIGQDQ SVYFSISQFP NYGALSHLNL 

       190        200        210        220        230        240 
EELRNSARID ADEYDKDNLC DFVLWKAYDP DRDGEIFWES PFGKGRPGWH LECSIMSISL 

       250        260        270        280        290        300 
LGQSLDIHAG GVDNIFPHHE NEIAQSESLS HKPFVRYWLH SHHLLVDRKK MSKSLGNFFT 

       310        320        330        340        350        360 
LRDLLDQGFS GEEVRYLLLQ GHYRTQLNFT QEGLHASRQS LKRLRDFICR LEDPSYPDDI 

       370        380        390        400        410        420 
IHPEVATACQ SFLETFITSL TNDLNISSSL AALFDFIRKI NSSIDQHTGI QTETDSSVFS 

       430        440        450        460        470        480 
KQDAQHILAL LRKIDQVLGV LPFSQPDIPE EVLLLVEQRE AARKVKNWQE ADRLRDEILS 

       490 
RGFAIEDGKT GMKVKKL

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References

[1]"Co-evolution of genomes and plasmids within Chlamydia trachomatis and the emergence in Sweden of a new variant strain."
Seth-Smith H.M., Harris S.R., Persson K., Marsh P., Barron A., Bignell A., Bjartling C., Clark L., Cutcliffe L.T., Lambden P.R., Lennard N., Lockey S.J., Quail M.A., Salim O., Skilton R.J., Wang Y., Holland M.J., Parkhill J., Thomson N.R., Clarke I.N.
BMC Genomics 10:239-239(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: TZ1A828/OT.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FM872307 Genomic DNA. Translation: CAX10348.1.
RefSeqYP_002889287.1. NC_012687.1.

3D structure databases

ProteinModelPortalC4PNU3.
ModBaseSearch...

Protein-protein interaction databases

STRING672161.CTB_7871.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAX10348; CAX10348; CTB_7871.
GeneID7883169.
KEGGctz:CTB_7871.
PATRIC20375185. VBIChlTra130039_0864.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0215.
HOGENOMHOG000245250.
KOK01883.
ProtClustDBPRK00260.

Enzyme and pathway databases

BioCycCTRA672161:GHKJ-468-MONOMER.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
HAMAPMF_00041. Cys_tRNA_synth.
InterProIPR015803. Cys-tRNA-ligase.
IPR015273. Cys-tRNA-synt_Ia_DALR.
IPR024909. Cys-tRNA/MSH_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR10890. PTHR10890. 1 hit.
PfamPF09190. DALR_2. 1 hit.
PF01406. tRNA-synt_1e. 1 hit.
[Graphical view]
PRINTSPR00983. TRNASYNTHCYS.
SMARTSM00840. DALR_2. 1 hit.
[Graphical view]
SUPFAMSSF47323. tRNAsyn_1a_bind. 1 hit.
TIGRFAMsTIGR00435. cysS. 1 hit.
ProtoNetSearch...

Entry information

Entry nameC4PNU3_CHLTZ
AccessionPrimary (citable) accession number: C4PNU3
Entry history
Integrated into UniProtKB/TrEMBL: July 7, 2009
Last sequence update: July 7, 2009
Last modified: May 1, 2013
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info