CASP 3

Functionⁱ

GO - Molecular functionⁱ

cysteine-type endopeptidase activity Source: InterPro

Complete GO annotation...

GO - Biological processⁱ

apoptotic process Source: InterPro

Complete GO annotation...

Keywordsⁱ

Molecular function	Hydrolase, Protease, Thiol proteaseSAAS annotation

Molecular function

Hydrolase, Protease, Thiol proteaseSAAS annotation

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	C14.003.

MEROPSⁱ

C14.003.

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Caspase 3Imported
Gene namesⁱ	Name:CASP 3Imported
Organismⁱ	Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)Imported
Taxonomic identifierⁱ	10029 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Cricetidae › Cricetinae › Cricetulus

Subcellular locationⁱ

GO - Cellular componentⁱ

cytoplasm Source: InterPro

Complete GO annotation...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	43 – 167	CASPASE_P20InterPro annotationAdd BLAST		125
Domainⁱ	183 – 277	CASPASE_P10InterPro annotationAdd BLAST		95

Sequence similaritiesⁱ

Belongs to the peptidase C14A family.UniRule annotationSAAS annotation

Phylogenomic databases

KEGG Orthology (KO) More...KOⁱ	K02187.

KOⁱ

K02187.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00032. CASc. 1 hit.
InterProⁱ	View protein in InterPro IPR029030. Caspase-like_dom. IPR015470. Caspase_3. IPR033139. Caspase_cys_AS. IPR016129. Caspase_his_AS. IPR002138. Pept_C14_p10. IPR001309. Pept_C14_p20. IPR015917. Pept_C14A.
PANTHERⁱ	PTHR10454:SF178. PTHR10454:SF178. 1 hit.
PRINTSⁱ	PR00376. IL1BCENZYME.
SMARTⁱ	View protein in SMART SM00115. CASc. 1 hit.
SUPFAMⁱ	SSF52129. SSF52129. 1 hit.
PROSITEⁱ	View protein in PROSITE PS01122. CASPASE_CYS. 1 hit. PS01121. CASPASE_HIS. 1 hit. PS50207. CASPASE_P10. 1 hit. PS50208. CASPASE_P20. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

C4PFX6-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MENNETSVDS KSIKNFEVKT IHGSKSMDSG MYLDNSYKMD YPEMGVCIII 
        60         70         80         90        100
NNKNFHKSTG MTPRSGTDVD AANLRETFMR LKYEVRNKND LTCGEIVELM 
       110        120        130        140        150
KNVSKEDHSR RSSFICVILS HGEEGVIFGT DGPVDLKKLT TYFRGDYCRS 
       160        170        180        190        200
LTGKPKLFII QACRGTELDC GIETDSGTDD DMACQKIPVE ADFLYAYSTA 
       210        220        230        240        250
PGYYSWRNSK DGSWFIQSLC AMLKLYAHKL EFMHILTRVN RKVAIEFESF 
       260        270 
SLDSTFHAKK QIPCIVSMLT KELYFYQ

Length:277

Mass (Da):31,608

Last modified:July 7, 2009 - v1

Checksum:ⁱ4EF91DB0E744189C

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	FJ940732 mRNA. Translation: ACR25272.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001230975.1. NM_001244046.1. XP_007639414.1. XM_007641224.2.

Genome annotation databases

GeneIDⁱ	100689061.
KEGGⁱ	cge:100689061.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	FJ940732 mRNA. Translation: ACR25272.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001230975.1. NM_001244046.1. XP_007639414.1. XM_007641224.2.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	C14.003.

MEROPSⁱ

C14.003.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	100689061.
KEGGⁱ	cge:100689061.

Organism-specific databases

CTDⁱ	836.

CTDⁱ

836.

Phylogenomic databases

KEGG Orthology (KO) More...KOⁱ	K02187.

KOⁱ

K02187.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00032. CASc. 1 hit.
InterProⁱ	View protein in InterPro IPR029030. Caspase-like_dom. IPR015470. Caspase_3. IPR033139. Caspase_cys_AS. IPR016129. Caspase_his_AS. IPR002138. Pept_C14_p10. IPR001309. Pept_C14_p20. IPR015917. Pept_C14A.
PANTHERⁱ	PTHR10454:SF178. PTHR10454:SF178. 1 hit.
PRINTSⁱ	PR00376. IL1BCENZYME.
SMARTⁱ	View protein in SMART SM00115. CASc. 1 hit.
SUPFAMⁱ	SSF52129. SSF52129. 1 hit.
PROSITEⁱ	View protein in PROSITE PS01122. CASPASE_CYS. 1 hit. PS01121. CASPASE_HIS. 1 hit. PS50207. CASPASE_P10. 1 hit. PS50208. CASPASE_P20. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	C4PFX6_CRIGR
Accessionⁱ	C4PFX6Primary (citable) accession number: C4PFX6
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	July 7, 2009
	Last sequence update:	July 7, 2009
	Last modified:	June 7, 2017
	This is version 32 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

UniProtKB - C4PFX6 (C4PFX6_CRIGR)

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Caspase 3

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Protein family/group databases

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Family & Domainsⁱ

Domains and Repeats

Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protein family/group databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Entry informationⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - C4PFX6 (C4PFX6_CRIGR)

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Caspase 3

CASP 3

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein family/group databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ