ID   C4P0D0_HUMAN            Unreviewed;       387 AA.
AC   C4P0D0;
DT   07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   07-JUL-2009, sequence version 1.
DT   22-FEB-2023, entry version 54.
DE   SubName: Full=Disrupted in schizophrenia 1 isoform 43 {ECO:0000313|EMBL:ACR40079.1};
GN   Name=DISC1 {ECO:0000313|EMBL:ACR40079.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:ACR40079.1};
RN   [1] {ECO:0000313|EMBL:ACR40079.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Nakata K., Lipska B.L., Hyde T.M., Ye T., Newburn E.N., Morita Y.,
RA   Vakkalanka R., Barenboim M., Sei Y., Weinberger D.R., Kleinman J.E.;
RT   "DISC1 splice variants are upregulated in schizophrenia and associated with
RT   risk polymorphisms.";
RL   Proc. Natl. Acad. Sci. U.S.A. 106:15873-15878(2009).
RN   [2] {ECO:0000313|EMBL:ACR40079.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Nakata K., Lipska B.K., Hyde T.M., Ye T., Fink E.N., Morita Y.,
RA   Vakkalanka R., Barenboim M., Sei Y., Weinberger D.R., Kleinman J.E.;
RT   "Novel Fetal DISC1 Splice Variants Are Upregulated in Schizophrenia and
RT   Associated with Risk Polymorphisms.";
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; FJ804213; ACR40079.1; -; mRNA.
DR   RefSeq; NP_001158025.1; NM_001164553.1.
DR   AlphaFoldDB; C4P0D0; -.
DR   PeptideAtlas; C4P0D0; -.
DR   DNASU; 27185; -.
DR   GeneID; 27185; -.
DR   CTD; 27185; -.
DR   PharmGKB; PA27342; -.
DR   OrthoDB; 4251541at2759; -.
DR   BioGRID-ORCS; 27185; 7 hits in 1143 CRISPR screens.
DR   GenomeRNAi; 27185; -.
DR   InterPro; IPR026081; DISC1.
DR   PANTHER; PTHR14332; DISRUPTED IN SCHIZOPHRENIA 1 PROTEIN; 1.
DR   PANTHER; PTHR14332:SF3; DISRUPTED IN SCHIZOPHRENIA 1 PROTEIN; 1.
DR   Genevisible; C4P0D0; HS.
PE   2: Evidence at transcript level;
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          179..205
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          221..257
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          278..323
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   387 AA;  40407 MW;  2B40BA509C9CDB24 CRC64;
     MPGGGPQGAP AAAGGGGVSH RAGSRDCLPP AACFRRRRLA RRPGYMRSST GPGIGFLSPA
     VGTLFRFPGG VSGEESHHSE SRARQCGLDS RGLLVRSPVS KSAAAPTVTS VRGTSAHFGI
     QLRGGTRLPD RLSWPCGPGS AGWQQEFAAM DSSETLDASW EAACSDGARR VRAAGSLPSA
     ELSSNSCSPG CGPEVPPTPP GSHSAFTSSF SFIRLSLGSA GERGEAEGCP PSREAESHCQ
     SPQEMGAKAA SLDGPHEDPR CLSRPFSLLA TRVSADLAQA ARNSSRPERD MHSLPDMDPG
     SSSSLDPSLA GCGGDGSSGS GDAHSWDTLL RKWEPVLRDC LLRNRRQMEV ISLRLKLQKL
     QEDAVENDDY DKAGTNCFGS TMEASTS
//