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Protein
Submitted name:

Disrupted in schizophrenia 1 isoform 43

Gene

DISC1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Submitted name:
Disrupted in schizophrenia 1 isoform 43Imported
Gene namesi
Name:DISC1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27342.

Expressioni

Gene expression databases

GenevisibleiC4P0D0. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000355593.

Family & Domainsi

Family and domain databases

InterProiIPR026081. DISC1.
[Graphical view]
PANTHERiPTHR14332. PTHR14332. 1 hit.

Sequencei

Sequence statusi: Complete.

C4P0D0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGGGPQGAP AAAGGGGVSH RAGSRDCLPP AACFRRRRLA RRPGYMRSST
60 70 80 90 100
GPGIGFLSPA VGTLFRFPGG VSGEESHHSE SRARQCGLDS RGLLVRSPVS
110 120 130 140 150
KSAAAPTVTS VRGTSAHFGI QLRGGTRLPD RLSWPCGPGS AGWQQEFAAM
160 170 180 190 200
DSSETLDASW EAACSDGARR VRAAGSLPSA ELSSNSCSPG CGPEVPPTPP
210 220 230 240 250
GSHSAFTSSF SFIRLSLGSA GERGEAEGCP PSREAESHCQ SPQEMGAKAA
260 270 280 290 300
SLDGPHEDPR CLSRPFSLLA TRVSADLAQA ARNSSRPERD MHSLPDMDPG
310 320 330 340 350
SSSSLDPSLA GCGGDGSSGS GDAHSWDTLL RKWEPVLRDC LLRNRRQMEV
360 370 380
ISLRLKLQKL QEDAVENDDY DKAGTNCFGS TMEASTS
Length:387
Mass (Da):40,407
Last modified:July 7, 2009 - v1
Checksum:i2B40BA509C9CDB24
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ804213 mRNA. Translation: ACR40079.1.
RefSeqiNP_001158025.1. NM_001164553.1.
UniGeneiHs.13318.

Genome annotation databases

GeneIDi27185.
UCSCiuc001hvc.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ804213 mRNA. Translation: ACR40079.1.
RefSeqiNP_001158025.1. NM_001164553.1.
UniGeneiHs.13318.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000355593.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi27185.
UCSCiuc001hvc.3. human.

Organism-specific databases

CTDi27185.
PharmGKBiPA27342.

Miscellaneous databases

GenomeRNAii27185.
NextBioi50024.

Gene expression databases

GenevisibleiC4P0D0. HS.

Family and domain databases

InterProiIPR026081. DISC1.
[Graphical view]
PANTHERiPTHR14332. PTHR14332. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "DISC1 splice variants are upregulated in schizophrenia and associated with risk polymorphisms."
    Nakata K., Lipska B.L., Hyde T.M., Ye T., Newburn E.N., Morita Y., Vakkalanka R., Barenboim M., Sei Y., Weinberger D.R., Kleinman J.E.
    Proc. Natl. Acad. Sci. U.S.A. 106:15873-15878(2009)
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Novel Fetal DISC1 Splice Variants Are Upregulated in Schizophrenia and Associated with Risk Polymorphisms."
    Nakata K., Lipska B.K., Hyde T.M., Ye T., Fink E.N., Morita Y., Vakkalanka R., Barenboim M., Sei Y., Weinberger D.R., Kleinman J.E.
    Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiC4P0D0_HUMAN
AccessioniPrimary (citable) accession number: C4P0D0
Entry historyi
Integrated into UniProtKB/TrEMBL: July 7, 2009
Last sequence update: July 7, 2009
Last modified: July 22, 2015
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.