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C4P0C8

- C4P0C8_HUMAN

UniProt

C4P0C8 - C4P0C8_HUMAN

Protein
Submitted name:

Disrupted in schizophrenia 1 isoform 41

Gene

DISC1

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 33 (01 Oct 2014)
      Sequence version 1 (07 Jul 2009)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. canonical Wnt signaling pathway Source: Ensembl
    2. cell proliferation in forebrain Source: Ensembl
    3. cerebral cortex radially oriented cell migration Source: Ensembl
    4. mitochondrial calcium ion homeostasis Source: Ensembl
    5. neuron migration Source: Ensembl
    6. positive regulation of neuroblast proliferation Source: Ensembl
    7. positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: Ensembl
    8. positive regulation of Wnt signaling pathway Source: Ensembl
    9. protein localization Source: Ensembl
    10. regulation of neuron projection development Source: Ensembl
    11. regulation of synapse maturation Source: Ensembl
    12. TOR signaling Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Disrupted in schizophrenia 1 isoform 41Imported
    Gene namesi
    Name:DISC1Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. centrosome Source: Ensembl

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA27342.

    Expressioni

    Gene expression databases

    ArrayExpressiC4P0C8.
    BgeeiC4P0C8.

    Structurei

    3D structure databases

    ProteinModelPortaliC4P0C8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    KOiK16534.

    Family and domain databases

    InterProiIPR026081. DISC1.
    [Graphical view]
    PANTHERiPTHR14332. PTHR14332. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C4P0C8-1 [UniParc]FASTAAdd to Basket

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    MPGGGPQGAP AAAGGGGVSH RAGSRDCLPP AACFRRRRLA RRPGYMRSST    50
    GPGIGFLSPA VGTLFRFPGG VSGEESHHSE SRARQCGLDS RGLLVRSPVS 100
    KSAAAPTVTS VRGTSAHFGI QLRGGTRLPD RLSWPCGPGS AGWQQEFAAM 150
    DSSETLDASW EAACSDGARR VRAAGSLPSA ELSSNSCSPG CGPEVPPTPP 200
    GSHSAFTSSF SFIRLSLGSA GERGEAEGCP PSREAESHCQ SPQEMGAKAA 250
    SLDGPHEDPR CLSRPFSLLA TRVSADLAQA ARNSSRPERD MHSLPDMDPG 300
    SSSSLDPSLA GCGGDGSSGS GDAHSWDTLL RKWEPVLRDC LLRNRRQMEV 350
    ISLRLKLQKL QEDAVENDDY DKAETLQQRL EDLEQEKISL HFQLPSRQPA 400
    LSSFLGHLAA QVQAALRRGA TQQ 423
    Length:423
    Mass (Da):44,655
    Last modified:July 7, 2009 - v1
    Checksum:i9BE445052FCFF7FA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FJ804211 mRNA. Translation: ACR40077.1.
    RefSeqiNP_001158023.1. NM_001164551.1.
    UniGeneiHs.13318.

    Genome annotation databases

    GeneIDi27185.
    KEGGihsa:27185.
    UCSCiuc010pwp.2. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FJ804211 mRNA. Translation: ACR40077.1 .
    RefSeqi NP_001158023.1. NM_001164551.1.
    UniGenei Hs.13318.

    3D structure databases

    ProteinModelPortali C4P0C8.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 27185.
    KEGGi hsa:27185.
    UCSCi uc010pwp.2. human.

    Organism-specific databases

    CTDi 27185.
    PharmGKBi PA27342.

    Phylogenomic databases

    KOi K16534.

    Miscellaneous databases

    GenomeRNAii 27185.
    NextBioi 50024.

    Gene expression databases

    ArrayExpressi C4P0C8.
    Bgeei C4P0C8.

    Family and domain databases

    InterProi IPR026081. DISC1.
    [Graphical view ]
    PANTHERi PTHR14332. PTHR14332. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "DISC1 splice variants are upregulated in schizophrenia and associated with risk polymorphisms."
      Nakata K., Lipska B.L., Hyde T.M., Ye T., Newburn E.N., Morita Y., Vakkalanka R., Barenboim M., Sei Y., Weinberger D.R., Kleinman J.E.
      Proc. Natl. Acad. Sci. U.S.A. 106:15873-15878(2009)
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "Novel Fetal DISC1 Splice Variants Are Upregulated in Schizophrenia and Associated with Risk Polymorphisms."
      Nakata K., Lipska B.K., Hyde T.M., Ye T., Fink E.N., Morita Y., Vakkalanka R., Barenboim M., Sei Y., Weinberger D.R., Kleinman J.E.
      Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiC4P0C8_HUMAN
    AccessioniPrimary (citable) accession number: C4P0C8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 7, 2009
    Last sequence update: July 7, 2009
    Last modified: October 1, 2014
    This is version 33 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.