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C4P0C8

- C4P0C8_HUMAN

UniProt

C4P0C8 - C4P0C8_HUMAN

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Protein
Submitted name:

Disrupted in schizophrenia 1 isoform 41

Gene

DISC1

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. canonical Wnt signaling pathway Source: Ensembl
  2. cell proliferation in forebrain Source: Ensembl
  3. cellular protein localization Source: Ensembl
  4. cerebral cortex radially oriented cell migration Source: Ensembl
  5. mitochondrial calcium ion homeostasis Source: Ensembl
  6. neuron migration Source: Ensembl
  7. positive regulation of neuroblast proliferation Source: Ensembl
  8. positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: Ensembl
  9. positive regulation of Wnt signaling pathway Source: Ensembl
  10. regulation of neuron projection development Source: Ensembl
  11. regulation of synapse maturation Source: Ensembl
  12. TOR signaling Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Disrupted in schizophrenia 1 isoform 41Imported
Gene namesi
Name:DISC1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. centrosome Source: Ensembl
  2. ciliary basal body Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27342.

Expressioni

Gene expression databases

BgeeiC4P0C8.
ExpressionAtlasiC4P0C8. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliC4P0C8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

KOiK16534.

Family and domain databases

InterProiIPR026081. DISC1.
[Graphical view]
PANTHERiPTHR14332. PTHR14332. 1 hit.

Sequencei

Sequence statusi: Complete.

C4P0C8-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MPGGGPQGAP AAAGGGGVSH RAGSRDCLPP AACFRRRRLA RRPGYMRSST
60 70 80 90 100
GPGIGFLSPA VGTLFRFPGG VSGEESHHSE SRARQCGLDS RGLLVRSPVS
110 120 130 140 150
KSAAAPTVTS VRGTSAHFGI QLRGGTRLPD RLSWPCGPGS AGWQQEFAAM
160 170 180 190 200
DSSETLDASW EAACSDGARR VRAAGSLPSA ELSSNSCSPG CGPEVPPTPP
210 220 230 240 250
GSHSAFTSSF SFIRLSLGSA GERGEAEGCP PSREAESHCQ SPQEMGAKAA
260 270 280 290 300
SLDGPHEDPR CLSRPFSLLA TRVSADLAQA ARNSSRPERD MHSLPDMDPG
310 320 330 340 350
SSSSLDPSLA GCGGDGSSGS GDAHSWDTLL RKWEPVLRDC LLRNRRQMEV
360 370 380 390 400
ISLRLKLQKL QEDAVENDDY DKAETLQQRL EDLEQEKISL HFQLPSRQPA
410 420
LSSFLGHLAA QVQAALRRGA TQQ
Length:423
Mass (Da):44,655
Last modified:July 7, 2009 - v1
Checksum:i9BE445052FCFF7FA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FJ804211 mRNA. Translation: ACR40077.1.
RefSeqiNP_001158023.1. NM_001164551.1.
UniGeneiHs.13318.

Genome annotation databases

GeneIDi27185.
KEGGihsa:27185.
UCSCiuc010pwp.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FJ804211 mRNA. Translation: ACR40077.1 .
RefSeqi NP_001158023.1. NM_001164551.1.
UniGenei Hs.13318.

3D structure databases

ProteinModelPortali C4P0C8.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 27185.
KEGGi hsa:27185.
UCSCi uc010pwp.2. human.

Organism-specific databases

CTDi 27185.
PharmGKBi PA27342.

Phylogenomic databases

KOi K16534.

Miscellaneous databases

GenomeRNAii 27185.
NextBioi 50024.

Gene expression databases

Bgeei C4P0C8.
ExpressionAtlasi C4P0C8. baseline and differential.

Family and domain databases

InterProi IPR026081. DISC1.
[Graphical view ]
PANTHERi PTHR14332. PTHR14332. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "DISC1 splice variants are upregulated in schizophrenia and associated with risk polymorphisms."
    Nakata K., Lipska B.L., Hyde T.M., Ye T., Newburn E.N., Morita Y., Vakkalanka R., Barenboim M., Sei Y., Weinberger D.R., Kleinman J.E.
    Proc. Natl. Acad. Sci. U.S.A. 106:15873-15878(2009)
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Novel Fetal DISC1 Splice Variants Are Upregulated in Schizophrenia and Associated with Risk Polymorphisms."
    Nakata K., Lipska B.K., Hyde T.M., Ye T., Fink E.N., Morita Y., Vakkalanka R., Barenboim M., Sei Y., Weinberger D.R., Kleinman J.E.
    Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiC4P0C8_HUMAN
AccessioniPrimary (citable) accession number: C4P0C8
Entry historyi
Integrated into UniProtKB/TrEMBL: July 7, 2009
Last sequence update: July 7, 2009
Last modified: October 29, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.