ID   C4P0A5_HUMAN            Unreviewed;       551 AA.
AC   C4P0A5;
DT   07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   07-JUL-2009, sequence version 1.
DT   13-SEP-2023, entry version 62.
DE   SubName: Full=Disrupted in schizophrenia 1 isoform 17 {ECO:0000313|EMBL:ACR40054.1};
DE   SubName: Full=Disrupted in schizophrenia 1 isoform 32 {ECO:0000313|EMBL:ACR40068.1};
GN   Name=DISC1 {ECO:0000313|EMBL:ACR40054.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:ACR40054.1};
RN   [1] {ECO:0000313|EMBL:ACR40054.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Nakata K., Lipska B.L., Hyde T.M., Ye T., Newburn E.N., Morita Y.,
RA   Vakkalanka R., Barenboim M., Sei Y., Weinberger D.R., Kleinman J.E.;
RT   "DISC1 splice variants are upregulated in schizophrenia and associated with
RT   risk polymorphisms.";
RL   Proc. Natl. Acad. Sci. U.S.A. 106:15873-15878(2009).
RN   [2] {ECO:0000313|EMBL:ACR40054.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Nakata K., Lipska B.K., Hyde T.M., Ye T., Fink E.N., Morita Y.,
RA   Vakkalanka R., Barenboim M., Sei Y., Weinberger D.R., Kleinman J.E.;
RT   "Novel Fetal DISC1 Splice Variants Are Upregulated in Schizophrenia and
RT   Associated with Risk Polymorphisms.";
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; FJ804188; ACR40054.1; -; mRNA.
DR   EMBL; FJ804202; ACR40068.1; -; mRNA.
DR   RefSeq; NP_001158020.1; NM_001164548.1.
DR   AlphaFoldDB; C4P0A5; -.
DR   SMR; C4P0A5; -.
DR   MaxQB; C4P0A5; -.
DR   PeptideAtlas; C4P0A5; -.
DR   DNASU; 27185; -.
DR   GeneID; 27185; -.
DR   CTD; 27185; -.
DR   PharmGKB; PA27342; -.
DR   OrthoDB; 4251541at2759; -.
DR   BioGRID-ORCS; 27185; 7 hits in 1143 CRISPR screens.
DR   GenomeRNAi; 27185; -.
DR   InterPro; IPR026081; DISC1.
DR   PANTHER; PTHR14332; DISRUPTED IN SCHIZOPHRENIA 1 PROTEIN; 1.
DR   PANTHER; PTHR14332:SF3; DISRUPTED IN SCHIZOPHRENIA 1 PROTEIN; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil {ECO:0000256|SAM:Coils}.
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          179..205
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          221..257
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          278..323
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          531..551
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          366..393
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          455..496
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   551 AA;  59299 MW;  23BC3EE366CD87A0 CRC64;
     MPGGGPQGAP AAAGGGGVSH RAGSRDCLPP AACFRRRRLA RRPGYMRSST GPGIGFLSPA
     VGTLFRFPGG VSGEESHHSE SRARQCGLDS RGLLVRSPVS KSAAAPTVTS VRGTSAHFGI
     QLRGGTRLPD RLSWPCGPGS AGWQQEFAAM DSSETLDASW EAACSDGARR VRAAGSLPSA
     ELSSNSCSPG CGPEVPPTPP GSHSAFTSSF SFIRLSLGSA GERGEAEGCP PSREAESHCQ
     SPQEMGAKAA SLDGPHEDPR CLSRPFSLLA TRVSADLAQA ARNSSRPERD MHSLPDMDPG
     SSSSLDPSLA GCGGDGSSGS GDAHSWDTLL RKWEPVLRDC LLRNRRQMEV ISLRLKLQKL
     QEDAVENDDY DKAETLQQRL EDLEQEKISL HFQLPSRQPA LSSFLGHLAA QVQAALRRGA
     TQQASGDDTH TPLRMEPRLL EPTAQDSLHV SITRRDWLLQ EKQQLQKEIE ALQARMFVLE
     AKDQQLRREI EEQEQQLQWQ GCDLTPLVGQ LSLGQLQEVS KALQDTLASA GQIPFHAEPP
     ETIRRKPFLD G
//