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Protein

Hsc70-interacting protein 1

Gene

HIP

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

One HIP oligomer binds the ATPase domains of at least two Hsc70 molecules dependent on activation of the Hsc70 ATPase by Hsp40. Stabilizes the ADP state of Hsc70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of Hsc70 with various target proteins (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-DME-3371453 Regulation of HSF1-mediated heat shock response

Names & Taxonomyi

Protein namesi
Recommended name:
Hsc70-interacting protein 11 Publication
Gene namesi
Name:HIP1 Publication
ORF Names:CG32789
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0260484 HIP

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003935841 – 377Hsc70-interacting protein 1Add BLAST377

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei80Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiC4NYP8

PTM databases

iPTMnetiC4NYP8

Expressioni

Gene expression databases

BgeeiFBgn0029676
ExpressionAtlasiC4NYP8 differential
GenevisibleiC4NYP8 DM

Interactioni

Subunit structurei

Homotetramer. Interacts with Hsc70 as well as DNAJ homologs and Hsp90 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi57855, 50 interactors
76808, 1 interactor
STRINGi7227.FBpp0070575

Structurei

3D structure databases

ProteinModelPortaliC4NYP8
SMRiC4NYP8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati126 – 159TPR 1Sequence analysisAdd BLAST34
Repeati161 – 193TPR 2Sequence analysisAdd BLAST33
Repeati195 – 227TPR 3Sequence analysisAdd BLAST33
Domaini294 – 336STI1Sequence analysisAdd BLAST43

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili239 – 276Sequence analysisAdd BLAST38

Sequence similaritiesi

Belongs to the FAM10 family.Sequence analysis

Keywords - Domaini

Coiled coil, Repeat, TPR repeat

Phylogenomic databases

eggNOGiENOG410IN5Q Eukaryota
COG0457 LUCA
InParanoidiC4NYP8
KOiK09560
OMAiTVLNMPQ
OrthoDBiEOG091G0KXF
PhylomeDBiC4NYP8

Family and domain databases

CDDicd14438 Hip_N, 1 hit
Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR034649 Hip_N
IPR006636 STI1_HS-bd
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
SMARTiView protein in SMART
SM00727 STI1, 1 hit
SM00028 TPR, 3 hits
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50005 TPR, 2 hits
PS50293 TPR_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

C4NYP8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFTMQTGDL KKLKYFIDFA LENPTFLNMP QLQFVKDFVE KFGGTVPPGQ
60 70 80 90 100
FNGGSAGGKC PFGGVAGAKA NEPANAPEDS EDEKSLSDPE SDVELDMEGV
110 120 130 140 150
IEADSDPAQP MGNYSKKATE EEVEQASELR AQAASAYGQQ KFDEAIALYT
160 170 180 190 200
KAIELSPGNA LFHAKRGQAF LKLKKPNACI RDCDVALELN SDLAAGYKFR
210 220 230 240 250
GRARRLLGDF ELAAHDLRQA CKLDFDEETD EWLKEVTPNA KKIEQHRLKQ
260 270 280 290 300
ERRQAERKIK ERQRDQRRAR KEQEKHNASS GGSSGEFSGG NPGNGNMSDI
310 320 330 340 350
LGAMSDPEVS AAIQDILSNP GNITKYASNP KIYNLIKKIV PGGDVGAAFG
360 370
QAGEKAGKPS EPKPKKDSAD FVDDGLD
Length:377
Mass (Da):41,037
Last modified:April 20, 2010 - v2
Checksum:iD62D41198348A786
GO

Sequence cautioni

The sequence ACX32977 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti105S → N in strain: XCPA112. 1 Publication1
Natural varianti227E → D in strain: XCPA25. 1 Publication1
Natural varianti290G → A in strain: XCPA77, XCPA93 and XCPA126. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ686088 Genomic DNA Translation: ACQ66626.1
FJ686092 Genomic DNA Translation: ACQ66627.1
FJ686093 Genomic DNA Translation: ACQ66628.1
FJ686094 Genomic DNA Translation: ACQ66629.1
FJ686095 Genomic DNA Translation: ACQ66630.1
AE014298 Genomic DNA Translation: AAN09108.2
BT099906 mRNA Translation: ACX32977.1 Different initiation.
RefSeqiNP_001014719.2, NM_001014719.2
NP_570074.3, NM_130718.5
NP_726885.1, NM_166988.4
NP_726886.1, NM_166989.5
UniGeneiDm.33464

Genome annotation databases

EnsemblMetazoaiFBtr0070597; FBpp0070572; FBgn0029676
FBtr0070598; FBpp0070573; FBgn0029676
FBtr0070600; FBpp0070575; FBgn0260484
FBtr0333764; FBpp0305905; FBgn0029676
GeneIDi31335
318211
KEGGidme:Dmel_CG2947
dme:Dmel_CG32789

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiF10A1_DROME
AccessioniPrimary (citable) accession number: C4NYP8
Secondary accession number(s): C0L9I4
, C0L9I8, C9QP24, Q8IRT4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: April 20, 2010
Last modified: April 25, 2018
This is version 63 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health