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C4M622

- C4M622_ENTHI

UniProt

C4M622 - C4M622_ENTHI

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Protein
Submitted name:

Diaphanous protein, putative

Gene
EHI_125300
Organism
Entamoeba histolytica
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. actin cytoskeleton organization Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Diaphanous protein, putativeImported
Gene namesi
ORF Names:EHI_125300Imported
OrganismiEntamoeba histolytica
Taxonomic identifieri5759 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaArchamoebaeEntamoebidaeEntamoeba
ProteomesiUP000001926: Partially assembled WGS sequence

Organism-specific databases

EuPathDBiAmoebaDB:EHI_125300.

Interactioni

Protein-protein interaction databases

STRINGi294381.C4M622.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4DVGX-ray2.60B69-418[»]

Family & Domainsi

Sequence similaritiesi

Contains FH(formin homology 2) domain.SAAS annotations
Contains FH2 (formin homology 2) domain.SAAS annotations

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR015425. FH2_Formin.
IPR010472. FH3_dom.
IPR010473. GTPase-bd.
IPR014768. GTPase-bd/formin_homology_3.
[Graphical view]
PfamiPF06367. Drf_FH3. 1 hit.
PF06371. Drf_GBD. 1 hit.
PF02181. FH2. 1 hit.
[Graphical view]
SMARTiSM00498. FH2. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS51444. FH2. 1 hit.
PS51232. GBD_FH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C4M622-1 [UniParc]FASTAAdd to Basket

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MDKIPHTFKD CTQPVENKKC VYCNKEIKKK QKAVYCTVCN IYLHEKKCID     50
KFRKEPTSCK RPIKVEVEMP PEEVVQQKFA IVAKEMKIDN PELITIPNQW 100
KLVQEYEKKQ KKDIRIQLNA QKTGNWRNAI TDPKYLADLL KTRDDMDLLN 150
EMVVVFRSSS VSFIKTFVSV GGLANLMAIY KKKIEAENSN TAIDEERKCC 200
EVLRYVFAEE DATVALIEID GGVELLLKGM NSKRITPDNQ LDILLEITLT 250
SSMVEHPSQE GLYLGGDVCV MNAFSNLVSE GVDMKKFLSF FSLFSKSKSE 300
KFKHASLVLI NNLIDQPELE HRMDVRNSFI EIGLVNELEN MKNTEWMKID 350
KIKDSINDFF DSWEEDKKEV ESRFDDLKQV VDFESTKSLN NYVTEQMDKF 400
ECNDILTNVH KEILFFAKVK DDNLLLIKKI VILTGIIRQI SLQVTKNNNE 450
KSNKKKIESG DNEEERIKID EVFDRMKLDW EKVTVDQSIL EDLNKKKQDL 500
KNSKEQLQIT LEKIKTIEKE VSSIDQENSE VNKELNDKKE KIQQIDTESK 550
KINDEIEEVK KKIEQTKKEL ASKPKGVSVS GTSSLAPPPP PPGATSVPPP 600
PPPPGASSIP PPPPPPGASS VPPPPPPPGM PGMPGMPPPP PPPGMPGMPP 650
PPPPPGMPGM PPPPPGMPGM PPPPPGMPGM PGMPPPPPGM PGMPPPPPGM 700
PGMPPPPPGG FGFRPAAPVI NGLVDTLPKP KSKVKNFMWQ KMNDKNLSGT 750
LFTKLDTLDK TKQKLDLSLI EAAFKVPEKV KPVADAAPKE TKKQGPICIL 800
DAKNNQTFTI LLKGFKNKTP EEVCAAINSV DQTVFEETST IKTMLKALED 850
AKEEIGQVEE HIKEKGTDNL GSAEMFVHAL NGVSNITLKL NSFQSKMELP 900
VKLEEVGPNI KHVIKASNQL LDSKKFIHLM EVILLMGNFL NSGTAKGNVA 950
GFKFETLNKT LDTKTGDNKR TLLHIIQEYA AEKLKEEVDG WQNEVTEIPL 1000
AAKVPGAQFE SDIKSLEKMY NDIQTAVGKI PEDGSKFHPI MKKFLEETRG 1050
KLDAVAKDFA EMNEIYKKAI QYMALDIAKP PPPEEFFTTL STFISNWNRV 1100
TEENKKLQAQ REKEAKKAEA AAAKKAGKKK TSLAPIPGEE GNMVKGRRQN 1150
PLAMEAAANV GGLKKTGFTF KKKTTKVLKT MDI 1183
Length:1,183
Mass (Da):131,980
Last modified:July 7, 2009 - v1
Checksum:iB059B50F50CFB75A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS571290 Genomic DNA. Translation: EAL48366.2.
RefSeqiXP_653752.2. XM_648660.2.

Genome annotation databases

EnsemblProtistsirna_EHI_125300-1; rna_EHI_125300-1; EHI_125300.
GeneIDi3408052.
KEGGiehi:EHI_125300.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS571290 Genomic DNA. Translation: EAL48366.2 .
RefSeqi XP_653752.2. XM_648660.2.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4DVG X-ray 2.60 B 69-418 [» ]
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 294381.C4M622.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi rna_EHI_125300-1 ; rna_EHI_125300-1 ; EHI_125300 .
GeneIDi 3408052.
KEGGi ehi:EHI_125300.

Organism-specific databases

EuPathDBi AmoebaDB:EHI_125300.

Family and domain databases

InterProi IPR016024. ARM-type_fold.
IPR015425. FH2_Formin.
IPR010472. FH3_dom.
IPR010473. GTPase-bd.
IPR014768. GTPase-bd/formin_homology_3.
[Graphical view ]
Pfami PF06367. Drf_FH3. 1 hit.
PF06371. Drf_GBD. 1 hit.
PF02181. FH2. 1 hit.
[Graphical view ]
SMARTi SM00498. FH2. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
PROSITEi PS51444. FH2. 1 hit.
PS51232. GBD_FH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 30459 / HM-1:IMSS.
  2. Lorenzi H., Amedeo P., Inman J., Schobel S., Caler E.
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: ATCC 30459 / HM-1:IMSS.
  3. "Entamoeba histolytica Rho1 regulates actin polymerization through a divergent, diaphanous-related formin."
    Bosch D.E., Yang B., Siderovski D.P.
    Biochemistry 51:8791-8801(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 69-418.

Entry informationi

Entry nameiC4M622_ENTHI
AccessioniPrimary (citable) accession number: C4M622
Entry historyi
Integrated into UniProtKB/TrEMBL: July 7, 2009
Last sequence update: July 7, 2009
Last modified: May 14, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteome

External Data

Dasty 3

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