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C4M622

- C4M622_ENTHI

UniProt

C4M622 - C4M622_ENTHI

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Protein
Submitted name:

Diaphanous protein, putative

Gene

EHI_125300

Organism
Entamoeba histolytica
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. actin cytoskeleton organization Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Diaphanous protein, putativeImported
Gene namesi
ORF Names:EHI_125300Imported
OrganismiEntamoeba histolyticaImported
Taxonomic identifieri5759 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaArchamoebaeEntamoebidaeEntamoeba
ProteomesiUP000001926: Partially assembled WGS sequence

Organism-specific databases

EuPathDBiAmoebaDB:EHI_125300.

Interactioni

Protein-protein interaction databases

STRINGi294381.C4M622.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4DVGX-ray2.60B69-418[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains FH(formin homology 2) domain.SAAS annotation
Contains FH2 (formin homology 2) domain.SAAS annotation

Phylogenomic databases

InParanoidiC4M622.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR015425. FH2_Formin.
IPR010472. FH3_dom.
IPR010473. GTPase-bd.
IPR014768. GTPase-bd/formin_homology_3.
[Graphical view]
PfamiPF06367. Drf_FH3. 1 hit.
PF06371. Drf_GBD. 1 hit.
PF02181. FH2. 1 hit.
[Graphical view]
SMARTiSM00498. FH2. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS51444. FH2. 1 hit.
PS51232. GBD_FH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C4M622-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDKIPHTFKD CTQPVENKKC VYCNKEIKKK QKAVYCTVCN IYLHEKKCID
60 70 80 90 100
KFRKEPTSCK RPIKVEVEMP PEEVVQQKFA IVAKEMKIDN PELITIPNQW
110 120 130 140 150
KLVQEYEKKQ KKDIRIQLNA QKTGNWRNAI TDPKYLADLL KTRDDMDLLN
160 170 180 190 200
EMVVVFRSSS VSFIKTFVSV GGLANLMAIY KKKIEAENSN TAIDEERKCC
210 220 230 240 250
EVLRYVFAEE DATVALIEID GGVELLLKGM NSKRITPDNQ LDILLEITLT
260 270 280 290 300
SSMVEHPSQE GLYLGGDVCV MNAFSNLVSE GVDMKKFLSF FSLFSKSKSE
310 320 330 340 350
KFKHASLVLI NNLIDQPELE HRMDVRNSFI EIGLVNELEN MKNTEWMKID
360 370 380 390 400
KIKDSINDFF DSWEEDKKEV ESRFDDLKQV VDFESTKSLN NYVTEQMDKF
410 420 430 440 450
ECNDILTNVH KEILFFAKVK DDNLLLIKKI VILTGIIRQI SLQVTKNNNE
460 470 480 490 500
KSNKKKIESG DNEEERIKID EVFDRMKLDW EKVTVDQSIL EDLNKKKQDL
510 520 530 540 550
KNSKEQLQIT LEKIKTIEKE VSSIDQENSE VNKELNDKKE KIQQIDTESK
560 570 580 590 600
KINDEIEEVK KKIEQTKKEL ASKPKGVSVS GTSSLAPPPP PPGATSVPPP
610 620 630 640 650
PPPPGASSIP PPPPPPGASS VPPPPPPPGM PGMPGMPPPP PPPGMPGMPP
660 670 680 690 700
PPPPPGMPGM PPPPPGMPGM PPPPPGMPGM PGMPPPPPGM PGMPPPPPGM
710 720 730 740 750
PGMPPPPPGG FGFRPAAPVI NGLVDTLPKP KSKVKNFMWQ KMNDKNLSGT
760 770 780 790 800
LFTKLDTLDK TKQKLDLSLI EAAFKVPEKV KPVADAAPKE TKKQGPICIL
810 820 830 840 850
DAKNNQTFTI LLKGFKNKTP EEVCAAINSV DQTVFEETST IKTMLKALED
860 870 880 890 900
AKEEIGQVEE HIKEKGTDNL GSAEMFVHAL NGVSNITLKL NSFQSKMELP
910 920 930 940 950
VKLEEVGPNI KHVIKASNQL LDSKKFIHLM EVILLMGNFL NSGTAKGNVA
960 970 980 990 1000
GFKFETLNKT LDTKTGDNKR TLLHIIQEYA AEKLKEEVDG WQNEVTEIPL
1010 1020 1030 1040 1050
AAKVPGAQFE SDIKSLEKMY NDIQTAVGKI PEDGSKFHPI MKKFLEETRG
1060 1070 1080 1090 1100
KLDAVAKDFA EMNEIYKKAI QYMALDIAKP PPPEEFFTTL STFISNWNRV
1110 1120 1130 1140 1150
TEENKKLQAQ REKEAKKAEA AAAKKAGKKK TSLAPIPGEE GNMVKGRRQN
1160 1170 1180
PLAMEAAANV GGLKKTGFTF KKKTTKVLKT MDI
Length:1,183
Mass (Da):131,980
Last modified:July 7, 2009 - v1
Checksum:iB059B50F50CFB75A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS571290 Genomic DNA. Translation: EAL48366.2.
RefSeqiXP_653752.2. XM_648660.2.

Genome annotation databases

EnsemblProtistsirna_EHI_125300-1; rna_EHI_125300-1; EHI_125300.
GeneIDi3408052.
KEGGiehi:EHI_125300.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS571290 Genomic DNA. Translation: EAL48366.2 .
RefSeqi XP_653752.2. XM_648660.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4DVG X-ray 2.60 B 69-418 [» ]
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 294381.C4M622.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi rna_EHI_125300-1 ; rna_EHI_125300-1 ; EHI_125300 .
GeneIDi 3408052.
KEGGi ehi:EHI_125300.

Organism-specific databases

EuPathDBi AmoebaDB:EHI_125300.

Phylogenomic databases

InParanoidi C4M622.

Family and domain databases

InterProi IPR016024. ARM-type_fold.
IPR015425. FH2_Formin.
IPR010472. FH3_dom.
IPR010473. GTPase-bd.
IPR014768. GTPase-bd/formin_homology_3.
[Graphical view ]
Pfami PF06367. Drf_FH3. 1 hit.
PF06371. Drf_GBD. 1 hit.
PF02181. FH2. 1 hit.
[Graphical view ]
SMARTi SM00498. FH2. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
PROSITEi PS51444. FH2. 1 hit.
PS51232. GBD_FH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 30459 / HM-1:IMSSImported.
  2. Lorenzi H., Amedeo P., Inman J., Schobel S., Caler E.
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: ATCC 30459 / HM-1:IMSSImported.
  3. "Entamoeba histolytica Rho1 regulates actin polymerization through a divergent, diaphanous-related formin."
    Bosch D.E., Yang B., Siderovski D.P.
    Biochemistry 51:8791-8801(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 69-418.

Entry informationi

Entry nameiC4M622_ENTHI
AccessioniPrimary (citable) accession number: C4M622
Entry historyi
Integrated into UniProtKB/TrEMBL: July 7, 2009
Last sequence update: July 7, 2009
Last modified: November 26, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteomeImported

External Data

Dasty 3