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C4M622

- C4M622_ENTHI

UniProt

C4M622 - C4M622_ENTHI

Protein
Submitted name:

Diaphanous protein, putative

Gene

EHI_125300

Organism
Entamoeba histolytica
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 33 (01 Oct 2014)
      Sequence version 1 (07 Jul 2009)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. actin cytoskeleton organization Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Diaphanous protein, putativeImported
    Gene namesi
    ORF Names:EHI_125300Imported
    OrganismiEntamoeba histolyticaImported
    Taxonomic identifieri5759 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaArchamoebaeEntamoebidaeEntamoeba
    ProteomesiUP000001926: Partially assembled WGS sequence

    Organism-specific databases

    EuPathDBiAmoebaDB:EHI_125300.

    Interactioni

    Protein-protein interaction databases

    STRINGi294381.C4M622.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4DVGX-ray2.60B69-418[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains FH2 (formin homology 2) domain.SAAS annotation

    Family and domain databases

    InterProiIPR016024. ARM-type_fold.
    IPR015425. FH2_Formin.
    IPR010472. FH3_dom.
    IPR010473. GTPase-bd.
    IPR014768. GTPase-bd/formin_homology_3.
    [Graphical view]
    PfamiPF06367. Drf_FH3. 1 hit.
    PF06371. Drf_GBD. 1 hit.
    PF02181. FH2. 1 hit.
    [Graphical view]
    SMARTiSM00498. FH2. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.
    PROSITEiPS51444. FH2. 1 hit.
    PS51232. GBD_FH3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C4M622-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDKIPHTFKD CTQPVENKKC VYCNKEIKKK QKAVYCTVCN IYLHEKKCID     50
    KFRKEPTSCK RPIKVEVEMP PEEVVQQKFA IVAKEMKIDN PELITIPNQW 100
    KLVQEYEKKQ KKDIRIQLNA QKTGNWRNAI TDPKYLADLL KTRDDMDLLN 150
    EMVVVFRSSS VSFIKTFVSV GGLANLMAIY KKKIEAENSN TAIDEERKCC 200
    EVLRYVFAEE DATVALIEID GGVELLLKGM NSKRITPDNQ LDILLEITLT 250
    SSMVEHPSQE GLYLGGDVCV MNAFSNLVSE GVDMKKFLSF FSLFSKSKSE 300
    KFKHASLVLI NNLIDQPELE HRMDVRNSFI EIGLVNELEN MKNTEWMKID 350
    KIKDSINDFF DSWEEDKKEV ESRFDDLKQV VDFESTKSLN NYVTEQMDKF 400
    ECNDILTNVH KEILFFAKVK DDNLLLIKKI VILTGIIRQI SLQVTKNNNE 450
    KSNKKKIESG DNEEERIKID EVFDRMKLDW EKVTVDQSIL EDLNKKKQDL 500
    KNSKEQLQIT LEKIKTIEKE VSSIDQENSE VNKELNDKKE KIQQIDTESK 550
    KINDEIEEVK KKIEQTKKEL ASKPKGVSVS GTSSLAPPPP PPGATSVPPP 600
    PPPPGASSIP PPPPPPGASS VPPPPPPPGM PGMPGMPPPP PPPGMPGMPP 650
    PPPPPGMPGM PPPPPGMPGM PPPPPGMPGM PGMPPPPPGM PGMPPPPPGM 700
    PGMPPPPPGG FGFRPAAPVI NGLVDTLPKP KSKVKNFMWQ KMNDKNLSGT 750
    LFTKLDTLDK TKQKLDLSLI EAAFKVPEKV KPVADAAPKE TKKQGPICIL 800
    DAKNNQTFTI LLKGFKNKTP EEVCAAINSV DQTVFEETST IKTMLKALED 850
    AKEEIGQVEE HIKEKGTDNL GSAEMFVHAL NGVSNITLKL NSFQSKMELP 900
    VKLEEVGPNI KHVIKASNQL LDSKKFIHLM EVILLMGNFL NSGTAKGNVA 950
    GFKFETLNKT LDTKTGDNKR TLLHIIQEYA AEKLKEEVDG WQNEVTEIPL 1000
    AAKVPGAQFE SDIKSLEKMY NDIQTAVGKI PEDGSKFHPI MKKFLEETRG 1050
    KLDAVAKDFA EMNEIYKKAI QYMALDIAKP PPPEEFFTTL STFISNWNRV 1100
    TEENKKLQAQ REKEAKKAEA AAAKKAGKKK TSLAPIPGEE GNMVKGRRQN 1150
    PLAMEAAANV GGLKKTGFTF KKKTTKVLKT MDI 1183
    Length:1,183
    Mass (Da):131,980
    Last modified:July 7, 2009 - v1
    Checksum:iB059B50F50CFB75A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS571290 Genomic DNA. Translation: EAL48366.2.
    RefSeqiXP_653752.2. XM_648660.2.

    Genome annotation databases

    EnsemblProtistsirna_EHI_125300-1; rna_EHI_125300-1; EHI_125300.
    GeneIDi3408052.
    KEGGiehi:EHI_125300.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS571290 Genomic DNA. Translation: EAL48366.2 .
    RefSeqi XP_653752.2. XM_648660.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4DVG X-ray 2.60 B 69-418 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 294381.C4M622.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi rna_EHI_125300-1 ; rna_EHI_125300-1 ; EHI_125300 .
    GeneIDi 3408052.
    KEGGi ehi:EHI_125300.

    Organism-specific databases

    EuPathDBi AmoebaDB:EHI_125300.

    Family and domain databases

    InterProi IPR016024. ARM-type_fold.
    IPR015425. FH2_Formin.
    IPR010472. FH3_dom.
    IPR010473. GTPase-bd.
    IPR014768. GTPase-bd/formin_homology_3.
    [Graphical view ]
    Pfami PF06367. Drf_FH3. 1 hit.
    PF06371. Drf_GBD. 1 hit.
    PF02181. FH2. 1 hit.
    [Graphical view ]
    SMARTi SM00498. FH2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    PROSITEi PS51444. FH2. 1 hit.
    PS51232. GBD_FH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 30459 / HM-1:IMSSImported.
    2. Lorenzi H., Amedeo P., Inman J., Schobel S., Caler E.
      Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: ATCC 30459 / HM-1:IMSSImported.
    3. "Entamoeba histolytica Rho1 regulates actin polymerization through a divergent, diaphanous-related formin."
      Bosch D.E., Yang B., Siderovski D.P.
      Biochemistry 51:8791-8801(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 69-418.

    Entry informationi

    Entry nameiC4M622_ENTHI
    AccessioniPrimary (citable) accession number: C4M622
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 7, 2009
    Last sequence update: July 7, 2009
    Last modified: October 1, 2014
    This is version 33 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3