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C4M5T2

- C4M5T2_ENTHI

UniProt

C4M5T2 - C4M5T2_ENTHI

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Protein
Submitted name:

Ubiquitin-conjugating enzyme family protein

Gene

EHI_070750

Organism
Entamoeba histolytica
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi32 – 321Cobalt; via tele nitrogenImported
Metal bindingi53 – 531CobaltImported
Metal bindingi55 – 551Cobalt; via tele nitrogenImported

GO - Molecular functioni

  1. acid-amino acid ligase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LigaseSAAS annotation

Keywords - Biological processi

Ubl conjugation pathwaySAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Ubiquitin-conjugating enzyme family proteinImported
Gene namesi
ORF Names:EHI_070750Imported, EHI_083560Imported
OrganismiEntamoeba histolyticaImported
Taxonomic identifieri5759 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaArchamoebaeEntamoebidaeEntamoeba
ProteomesiUP000001926: Partially assembled WGS sequence

Interactioni

Protein-protein interaction databases

STRINGi294381.C4M5T2.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4GPRX-ray1.60A1-148[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.UniRule annotation

Phylogenomic databases

KOiK06689.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C4M5T2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAMRRIQKEL REIQQDPPCN CSAGPVGDDI FHWTATITGP DDSPYQGGLF
60 70 80 90 100
FLDVHFPVDY PFKAPRVTFM TKVYHPNINK NGVICLDILK DQWSPALTLS
110 120 130 140
RVLLSISSLL TDPNPSDPLD PEVANVLRAN KKQFEDTARE WTRMYARP
Length:148
Mass (Da):16,831
Last modified:July 7, 2009 - v1
Checksum:i1DD179CFDB003139
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS571388 Genomic DNA. Translation: EAL47305.1.
DS571284 Genomic DNA. Translation: EAL49024.1.
RefSeqiXP_652691.1. XM_647599.1.
XP_654416.1. XM_649324.2.

Genome annotation databases

EnsemblProtistsirna_EHI_070750-1; rna_EHI_070750-1; EHI_070750.
rna_EHI_083560-1; rna_EHI_083560-1; EHI_083560.
GeneIDi3407002.
3408716.
KEGGiehi:EHI_070750.
ehi:EHI_083560.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS571388 Genomic DNA. Translation: EAL47305.1 .
DS571284 Genomic DNA. Translation: EAL49024.1 .
RefSeqi XP_652691.1. XM_647599.1.
XP_654416.1. XM_649324.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4GPR X-ray 1.60 A 1-148 [» ]
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 294381.C4M5T2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi rna_EHI_070750-1 ; rna_EHI_070750-1 ; EHI_070750 .
rna_EHI_083560-1 ; rna_EHI_083560-1 ; EHI_083560 .
GeneIDi 3407002.
3408716.
KEGGi ehi:EHI_070750.
ehi:EHI_083560.

Phylogenomic databases

KOi K06689.

Family and domain databases

Gene3Di 3.10.110.10. 1 hit.
InterProi IPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view ]
Pfami PF00179. UQ_con. 1 hit.
[Graphical view ]
SUPFAMi SSF54495. SSF54495. 1 hit.
PROSITEi PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 30459 / HM-1:IMSSImported.
  2. Lorenzi H., Amedeo P., Inman J., Schobel S., Caler E.
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: ATCC 30459 / HM-1:IMSSImported.
  3. "Structural determinants of ubiquitin conjugation in Entamoeba histolytica."
    Bosch D.E., Siderovski D.P.
    J. Biol. Chem. 288:2290-2302(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS).

Entry informationi

Entry nameiC4M5T2_ENTHI
AccessioniPrimary (citable) accession number: C4M5T2
Entry historyi
Integrated into UniProtKB/TrEMBL: July 7, 2009
Last sequence update: July 7, 2009
Last modified: November 26, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteomeImported

External Data

Dasty 3