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C4M5T2

- C4M5T2_ENTHI

UniProt

C4M5T2 - C4M5T2_ENTHI

Protein
Submitted name:

Ubiquitin-conjugating enzyme family protein

Gene

EHI_070750

Organism
Entamoeba histolytica
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 35 (01 Oct 2014)
      Sequence version 1 (07 Jul 2009)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi32 – 321Cobalt; via tele nitrogenImported
    Metal bindingi53 – 531CobaltImported
    Metal bindingi55 – 551Cobalt; via tele nitrogenImported

    GO - Molecular functioni

    1. acid-amino acid ligase activity Source: InterPro
    2. metal ion binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    LigaseSAAS annotation

    Keywords - Biological processi

    Ubl conjugation pathwaySAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Ubiquitin-conjugating enzyme family proteinImported
    Gene namesi
    ORF Names:EHI_070750Imported, EHI_083560Imported
    OrganismiEntamoeba histolyticaImported
    Taxonomic identifieri5759 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaArchamoebaeEntamoebidaeEntamoeba
    ProteomesiUP000001926: Partially assembled WGS sequence

    Interactioni

    Protein-protein interaction databases

    STRINGi294381.C4M5T2.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4GPRX-ray1.60A1-148[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ubiquitin-conjugating enzyme family.UniRule annotation

    Phylogenomic databases

    KOiK06689.

    Family and domain databases

    Gene3Di3.10.110.10. 1 hit.
    InterProiIPR000608. UBQ-conjugat_E2.
    IPR023313. UBQ-conjugating_AS.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view]
    PfamiPF00179. UQ_con. 1 hit.
    [Graphical view]
    SUPFAMiSSF54495. SSF54495. 1 hit.
    PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
    PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C4M5T2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAMRRIQKEL REIQQDPPCN CSAGPVGDDI FHWTATITGP DDSPYQGGLF    50
    FLDVHFPVDY PFKAPRVTFM TKVYHPNINK NGVICLDILK DQWSPALTLS 100
    RVLLSISSLL TDPNPSDPLD PEVANVLRAN KKQFEDTARE WTRMYARP 148
    Length:148
    Mass (Da):16,831
    Last modified:July 7, 2009 - v1
    Checksum:i1DD179CFDB003139
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS571388 Genomic DNA. Translation: EAL47305.1.
    DS571284 Genomic DNA. Translation: EAL49024.1.
    RefSeqiXP_652691.1. XM_647599.1.
    XP_654416.1. XM_649324.2.

    Genome annotation databases

    EnsemblProtistsirna_EHI_070750-1; rna_EHI_070750-1; EHI_070750.
    rna_EHI_083560-1; rna_EHI_083560-1; EHI_083560.
    GeneIDi3407002.
    3408716.
    KEGGiehi:EHI_070750.
    ehi:EHI_083560.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS571388 Genomic DNA. Translation: EAL47305.1 .
    DS571284 Genomic DNA. Translation: EAL49024.1 .
    RefSeqi XP_652691.1. XM_647599.1.
    XP_654416.1. XM_649324.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4GPR X-ray 1.60 A 1-148 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 294381.C4M5T2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi rna_EHI_070750-1 ; rna_EHI_070750-1 ; EHI_070750 .
    rna_EHI_083560-1 ; rna_EHI_083560-1 ; EHI_083560 .
    GeneIDi 3407002.
    3408716.
    KEGGi ehi:EHI_070750.
    ehi:EHI_083560.

    Phylogenomic databases

    KOi K06689.

    Family and domain databases

    Gene3Di 3.10.110.10. 1 hit.
    InterProi IPR000608. UBQ-conjugat_E2.
    IPR023313. UBQ-conjugating_AS.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view ]
    Pfami PF00179. UQ_con. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54495. SSF54495. 1 hit.
    PROSITEi PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
    PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 30459 / HM-1:IMSSImported.
    2. Lorenzi H., Amedeo P., Inman J., Schobel S., Caler E.
      Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: ATCC 30459 / HM-1:IMSSImported.
    3. "Structural determinants of ubiquitin conjugation in Entamoeba histolytica."
      Bosch D.E., Siderovski D.P.
      J. Biol. Chem. 288:2290-2302(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS).

    Entry informationi

    Entry nameiC4M5T2_ENTHI
    AccessioniPrimary (citable) accession number: C4M5T2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 7, 2009
    Last sequence update: July 7, 2009
    Last modified: October 1, 2014
    This is version 35 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3