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C4M5T2

- C4M5T2_ENTHI

UniProt

C4M5T2 - C4M5T2_ENTHI

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Protein
Submitted name: Ubiquitin-conjugating enzyme family protein
Gene
EHI_070750, EHI_083560
Organism
Entamoeba histolytica
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi32 – 321Cobalt; via tele nitrogenImported
Metal bindingi53 – 531CobaltImported
Metal bindingi55 – 551Cobalt; via tele nitrogenImported

GO - Molecular functioni

  1. acid-amino acid ligase activity Source: InterPro
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseSAAS annotations

Keywords - Biological processi

Ubl conjugation pathwaySAAS annotations

Keywords - Ligandi

CobaltImported, Metal-bindingImported

Names & Taxonomyi

Protein namesi
Submitted name:
Ubiquitin-conjugating enzyme family proteinImported
Gene namesi
ORF Names:EHI_070750Imported, EHI_083560Imported
OrganismiEntamoeba histolytica
Taxonomic identifieri5759 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaArchamoebaeEntamoebidaeEntamoeba
ProteomesiUP000001926: Partially assembled WGS sequence

Interactioni

Protein-protein interaction databases

STRINGi294381.C4M5T2.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4GPRX-ray1.60A1-148[»]

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK06689.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C4M5T2-1 [UniParc]FASTAAdd to Basket

« Hide

MAMRRIQKEL REIQQDPPCN CSAGPVGDDI FHWTATITGP DDSPYQGGLF    50
FLDVHFPVDY PFKAPRVTFM TKVYHPNINK NGVICLDILK DQWSPALTLS 100
RVLLSISSLL TDPNPSDPLD PEVANVLRAN KKQFEDTARE WTRMYARP 148
Length:148
Mass (Da):16,831
Last modified:July 7, 2009 - v1
Checksum:i1DD179CFDB003139
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS571388 Genomic DNA. Translation: EAL47305.1.
DS571284 Genomic DNA. Translation: EAL49024.1.
RefSeqiXP_652691.1. XM_647599.1.
XP_654416.1. XM_649324.2.

Genome annotation databases

EnsemblProtistsirna_EHI_070750-1; rna_EHI_070750-1; EHI_070750.
rna_EHI_083560-1; rna_EHI_083560-1; EHI_083560.
GeneIDi3407002.
3408716.
KEGGiehi:EHI_070750.
ehi:EHI_083560.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS571388 Genomic DNA. Translation: EAL47305.1 .
DS571284 Genomic DNA. Translation: EAL49024.1 .
RefSeqi XP_652691.1. XM_647599.1.
XP_654416.1. XM_649324.2.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4GPR X-ray 1.60 A 1-148 [» ]
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 294381.C4M5T2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi rna_EHI_070750-1 ; rna_EHI_070750-1 ; EHI_070750 .
rna_EHI_083560-1 ; rna_EHI_083560-1 ; EHI_083560 .
GeneIDi 3407002.
3408716.
KEGGi ehi:EHI_070750.
ehi:EHI_083560.

Phylogenomic databases

KOi K06689.

Family and domain databases

Gene3Di 3.10.110.10. 1 hit.
InterProi IPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view ]
Pfami PF00179. UQ_con. 1 hit.
[Graphical view ]
SUPFAMi SSF54495. SSF54495. 1 hit.
PROSITEi PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 30459 / HM-1:IMSS.
  2. Lorenzi H., Amedeo P., Inman J., Schobel S., Caler E.
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: ATCC 30459 / HM-1:IMSS.
  3. "Structural determinants of ubiquitin conjugation in Entamoeba histolytica."
    Bosch D.E., Siderovski D.P.
    J. Biol. Chem. 288:2290-2302(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) IN COMPLEX WITH COBALT.

Entry informationi

Entry nameiC4M5T2_ENTHI
AccessioniPrimary (citable) accession number: C4M5T2
Entry historyi
Integrated into UniProtKB/TrEMBL: July 7, 2009
Last sequence update: July 7, 2009
Last modified: June 11, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteome

External Data

Dasty 3

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