C4M5T2 (C4M5T2_ENTHI) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Ubiquitin-conjugating enzyme family protein EMBL EAL49024.1

Gene names

ORF Names:

EHI_070750 EMBL EAL49024.1, EHI_083560 EMBL EAL47305.1

Organism

Entamoeba histolytica [Reference proteome]

Taxonomic identifier

5759 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Amoebozoa › Archamoebae › Entamoebidae › Entamoeba

Protein attributes

Sequence length	148 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the ubiquitin-conjugating enzyme family. RuleBase RU004027

Ontologies

Keywords
Biological process	Ubl conjugation pathway SAAS SAAS023313
Molecular function	Ligase SAAS SAAS023313
Technical term	3D-structure PDB 4GPR Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	acid-amino acid ligase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	C4M5T2 [UniParc]. Last modified July 7, 2009. Version 1. Checksum: 1DD179CFDB003139	FASTA	148	16,831
	10 20 30 40 50 60 MAMRRIQKEL REIQQDPPCN CSAGPVGDDI FHWTATITGP DDSPYQGGLF FLDVHFPVDY 70 80 90 100 110 120 PFKAPRVTFM TKVYHPNINK NGVICLDILK DQWSPALTLS RVLLSISSLL TDPNPSDPLD 130 140 PEVANVLRAN KKQFEDTARE WTRMYARP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome of the protist parasite Entamoeba histolytica." Loftus B.J., Anderson I., Davies R., Alsmark U.C., Samuelson J., Amedeo P., Roncaglia P., Berriman M., Hirt R.P., Mann B.J., Nozaki T., Suh B., Pop M., Duchene M., Ackers J., Tannich E., Leippe M., Hofer M. , Bruchhaus I., Willhoeft U., Bhattacharya A., Chillingworth T., Churcher C.M., Hance Z., Harris B., Harris D., Jagels K., Moule S., Mungall K.L., Ormond D., Squares R., Whitehead S., Quail M.A., Rabbinowitsch E., Norbertczak H., Price C., Wang Z., Guillen N., Gilchrist C., Stroup S.E., Bhattacharya S., Lohia A., Foster P.G., Sicheritz-Ponten T., Weber C., Singh U., Mukherjee C., El-Sayed N.M.A., Petri W.A., Clark C.G., Embley T.M., Barrell B.G., Fraser C.M., Hall N. Nature 433:865-868(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 30459 / HM-1:IMSS.
[2]	Lorenzi H., Amedeo P., Inman J., Schobel S., Caler E. Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 30459 / HM-1:IMSS.
[3]	"Structural determinants of ubiquitin conjugation in Entamoeba histolytica." Bosch D.E., Siderovski D.P. J. Biol. Chem. 288:2290-2302(2013) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

DS571388 Genomic DNA. Translation: EAL47305.1.
DS571284 Genomic DNA. Translation: EAL49024.1.

RefSeq

XP_652691.1. XM_647599.1.
XP_654416.1. XM_649324.2.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
4GPR	X-ray	1.60	A	1-148	[»]

SMR

C4M5T2. Positions 1-146.

ModBase

Search...

Protein-protein interaction databases

STRING

294381.C4M5T2.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblProtists

rna_EHI_070750-1; rna_EHI_070750-1; EHI_070750.
rna_EHI_083560-1; rna_EHI_083560-1; EHI_083560.

GeneID

3407002.
3408716.

KEGG

ehi:EHI_070750.
ehi:EHI_083560.

Phylogenomic databases

KO

K06689.

ProtClustDB

CLSZ2731260.

Family and domain databases

Gene3D

3.10.110.10. 1 hit.

InterPro

IPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]

Pfam

PF00179. UQ_con. 1 hit.
[Graphical view]

SUPFAM

SSF54495. UBQ-conjugat/RWD-like. 1 hit.

PROSITE

PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

C4M5T2_ENTHI

Accession

Primary (citable) accession number: C4M5T2

Entry history

Integrated into UniProtKB/TrEMBL:	July 7, 2009
Last sequence update:	July 7, 2009
Last modified:	May 1, 2013
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)