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C4M5H3

- C4M5H3_ENTHI

UniProt

C4M5H3 - C4M5H3_ENTHI

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Protein

DNA ligase

Gene
EHI_111060
Organism
Entamoeba histolytica
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA ligation involved in DNA repair Source: InterPro
  2. DNA recombination Source: UniProtKB-KW
  3. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
ORF Names:EHI_111060Imported
OrganismiEntamoeba histolytica
Taxonomic identifieri5759 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaArchamoebaeEntamoebidaeEntamoeba
ProteomesiUP000001926: Partially assembled WGS sequence

Organism-specific databases

EuPathDBiAmoebaDB:EHI_111060.

Interactioni

Protein-protein interaction databases

STRINGi294381.C4M5H3.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK10747.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C4M5H3-1 [UniParc]FASTAAdd to Basket

« Hide

MSKRQSSLSR FFKPAKRATV GGQNNGENKS DEKGNEKKKQ ESIEEKNQSL    50
QIKEEGNSFP EQKVKTLPFK GLADCFDALE NESGKLKKRE IYANYLKTVI 100
TICPNDLTDV LNLTTGQIAP TWEGKELGIG DAILKDVVKS VTGLKLSQLN 150
DKIKELGDIG IVAQNSKKNQ KLLVQPKPLT IQGVVLRMKE ILEADNSDIK 200
KNKITALLVA AIGNEIRFIL RILKGVFRIG FTDRSLPPAI AQAVCSIRKE 250
NNRIEELTEL ITNAVARVPS FQYLSEHITA NDPFEEFAKT NSVQLFIPFR 300
PMLAKPKKSI TDITSRFKFP FTAEYKYDGE RGQIHFNKNK IMVFTRNLEN 350
YTEKYPDVIE AVKDAVNPNI QSFIIDCEIV AFNRETNEFQ EFQILGRRAK 400
KGVSVHSIAI NVCVNVFDIV YLNGKDLMDK PLKERRDILH STFHEVSQRF 450
LFARFKNIEN EEDILPFFEE AINHRTEGLM CKTLIYDAEY IPDKRTDTWY 500
KLKKDYLNGL ADTVDLVPVG AWMGEGKRAG VYGAFLLACR DEDSGDFETV 550
TKVGTGFSDE ALQKLYEHLK TLECKEKKNV KHGDNLPDVW FEPKDVWEIK 600
GADLSLSLQY KAGTKLVNTE GRGVCLRFPR YIRSRDDKEV NDITTNKQIY 650
DLYKDQPSVR ETKDGQMKII NNDNEEESQE SEEKE 685
Length:685
Mass (Da):78,164
Last modified:July 7, 2009 - v1
Checksum:i594BA9A4207F93B7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS571279 Genomic DNA. Translation: EAL52210.1.
RefSeqiXP_657595.1. XM_652503.2.

Genome annotation databases

EnsemblProtistsirna_EHI_111060-1; rna_EHI_111060-1; EHI_111060.
GeneIDi3411902.
KEGGiehi:EHI_111060.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS571279 Genomic DNA. Translation: EAL52210.1 .
RefSeqi XP_657595.1. XM_652503.2.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 294381.C4M5H3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi rna_EHI_111060-1 ; rna_EHI_111060-1 ; EHI_111060 .
GeneIDi 3411902.
KEGGi ehi:EHI_111060.

Organism-specific databases

EuPathDBi AmoebaDB:EHI_111060.

Phylogenomic databases

KOi K10747.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProi IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 30459 / HM-1:IMSS.
  2. Lorenzi H., Amedeo P., Inman J., Schobel S., Caler E.
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: ATCC 30459 / HM-1:IMSS.

Entry informationi

Entry nameiC4M5H3_ENTHI
AccessioniPrimary (citable) accession number: C4M5H3
Entry historyi
Integrated into UniProtKB/TrEMBL: July 7, 2009
Last sequence update: July 7, 2009
Last modified: May 14, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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