Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

DNA ligase

Gene

EHI_111060

Organism
Entamoeba histolytica
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported
Biological processDNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BRENDAi6.5.1.1 2080

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
ORF Names:EHI_111060Imported
OrganismiEntamoeba histolyticaImported
Taxonomic identifieri5759 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaArchamoebaeEntamoebidaeEntamoeba
Proteomesi
  • UP000001926 Componenti: Partially assembled WGS sequence

Organism-specific databases

EuPathDBiAmoebaDB:EHI_111060

Subcellular locationi

GO - Cellular componenti

Interactioni

Protein-protein interaction databases

STRINGi5759.rna_EHI_111060-1

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili240 – 267Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0967 Eukaryota
COG1793 LUCA
InParanoidiC4M5H3
KOiK10747
OMAiWIKYKRD

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
InterProiView protein in InterPro
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00697 DNA_LIGASE_A1, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

C4M5H3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKRQSSLSR FFKPAKRATV GGQNNGENKS DEKGNEKKKQ ESIEEKNQSL
60 70 80 90 100
QIKEEGNSFP EQKVKTLPFK GLADCFDALE NESGKLKKRE IYANYLKTVI
110 120 130 140 150
TICPNDLTDV LNLTTGQIAP TWEGKELGIG DAILKDVVKS VTGLKLSQLN
160 170 180 190 200
DKIKELGDIG IVAQNSKKNQ KLLVQPKPLT IQGVVLRMKE ILEADNSDIK
210 220 230 240 250
KNKITALLVA AIGNEIRFIL RILKGVFRIG FTDRSLPPAI AQAVCSIRKE
260 270 280 290 300
NNRIEELTEL ITNAVARVPS FQYLSEHITA NDPFEEFAKT NSVQLFIPFR
310 320 330 340 350
PMLAKPKKSI TDITSRFKFP FTAEYKYDGE RGQIHFNKNK IMVFTRNLEN
360 370 380 390 400
YTEKYPDVIE AVKDAVNPNI QSFIIDCEIV AFNRETNEFQ EFQILGRRAK
410 420 430 440 450
KGVSVHSIAI NVCVNVFDIV YLNGKDLMDK PLKERRDILH STFHEVSQRF
460 470 480 490 500
LFARFKNIEN EEDILPFFEE AINHRTEGLM CKTLIYDAEY IPDKRTDTWY
510 520 530 540 550
KLKKDYLNGL ADTVDLVPVG AWMGEGKRAG VYGAFLLACR DEDSGDFETV
560 570 580 590 600
TKVGTGFSDE ALQKLYEHLK TLECKEKKNV KHGDNLPDVW FEPKDVWEIK
610 620 630 640 650
GADLSLSLQY KAGTKLVNTE GRGVCLRFPR YIRSRDDKEV NDITTNKQIY
660 670 680
DLYKDQPSVR ETKDGQMKII NNDNEEESQE SEEKE
Length:685
Mass (Da):78,164
Last modified:July 7, 2009 - v1
Checksum:i594BA9A4207F93B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS571279 Genomic DNA Translation: EAL52210.1
RefSeqiXP_657595.1, XM_652503.2

Genome annotation databases

EnsemblProtistsiGAT96687; GAT96687; CL6EHI_111060
rna_EHI_111060-1; rna_EHI_111060-1; EHI_111060
GeneIDi3411902
KEGGiehi:EHI_111060

Similar proteinsi

Entry informationi

Entry nameiC4M5H3_ENTHI
AccessioniPrimary (citable) accession number: C4M5H3
Entry historyiIntegrated into UniProtKB/TrEMBL: July 7, 2009
Last sequence update: July 7, 2009
Last modified: March 28, 2018
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health