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C4M5H3

- C4M5H3_ENTHI

UniProt

C4M5H3 - C4M5H3_ENTHI

Protein

DNA ligase

Gene

EHI_111060

Organism
Entamoeba histolytica
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 34 (01 Oct 2014)
      Sequence version 1 (07 Jul 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA ligation involved in DNA repair Source: InterPro
    2. DNA recombination Source: UniProtKB-KW
    3. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Gene namesi
    ORF Names:EHI_111060Imported
    OrganismiEntamoeba histolyticaImported
    Taxonomic identifieri5759 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaArchamoebaeEntamoebidaeEntamoeba
    ProteomesiUP000001926: Partially assembled WGS sequence

    Organism-specific databases

    EuPathDBiAmoebaDB:EHI_111060.

    Interactioni

    Protein-protein interaction databases

    STRINGi294381.C4M5H3.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    KOiK10747.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    InterProiIPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C4M5H3-1 [UniParc]FASTAAdd to Basket

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    MSKRQSSLSR FFKPAKRATV GGQNNGENKS DEKGNEKKKQ ESIEEKNQSL    50
    QIKEEGNSFP EQKVKTLPFK GLADCFDALE NESGKLKKRE IYANYLKTVI 100
    TICPNDLTDV LNLTTGQIAP TWEGKELGIG DAILKDVVKS VTGLKLSQLN 150
    DKIKELGDIG IVAQNSKKNQ KLLVQPKPLT IQGVVLRMKE ILEADNSDIK 200
    KNKITALLVA AIGNEIRFIL RILKGVFRIG FTDRSLPPAI AQAVCSIRKE 250
    NNRIEELTEL ITNAVARVPS FQYLSEHITA NDPFEEFAKT NSVQLFIPFR 300
    PMLAKPKKSI TDITSRFKFP FTAEYKYDGE RGQIHFNKNK IMVFTRNLEN 350
    YTEKYPDVIE AVKDAVNPNI QSFIIDCEIV AFNRETNEFQ EFQILGRRAK 400
    KGVSVHSIAI NVCVNVFDIV YLNGKDLMDK PLKERRDILH STFHEVSQRF 450
    LFARFKNIEN EEDILPFFEE AINHRTEGLM CKTLIYDAEY IPDKRTDTWY 500
    KLKKDYLNGL ADTVDLVPVG AWMGEGKRAG VYGAFLLACR DEDSGDFETV 550
    TKVGTGFSDE ALQKLYEHLK TLECKEKKNV KHGDNLPDVW FEPKDVWEIK 600
    GADLSLSLQY KAGTKLVNTE GRGVCLRFPR YIRSRDDKEV NDITTNKQIY 650
    DLYKDQPSVR ETKDGQMKII NNDNEEESQE SEEKE 685
    Length:685
    Mass (Da):78,164
    Last modified:July 7, 2009 - v1
    Checksum:i594BA9A4207F93B7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS571279 Genomic DNA. Translation: EAL52210.1.
    RefSeqiXP_657595.1. XM_652503.2.

    Genome annotation databases

    EnsemblProtistsirna_EHI_111060-1; rna_EHI_111060-1; EHI_111060.
    GeneIDi3411902.
    KEGGiehi:EHI_111060.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS571279 Genomic DNA. Translation: EAL52210.1 .
    RefSeqi XP_657595.1. XM_652503.2.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 294381.C4M5H3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi rna_EHI_111060-1 ; rna_EHI_111060-1 ; EHI_111060 .
    GeneIDi 3411902.
    KEGGi ehi:EHI_111060.

    Organism-specific databases

    EuPathDBi AmoebaDB:EHI_111060.

    Phylogenomic databases

    KOi K10747.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    InterProi IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 30459 / HM-1:IMSSImported.
    2. Lorenzi H., Amedeo P., Inman J., Schobel S., Caler E.
      Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: ATCC 30459 / HM-1:IMSSImported.

    Entry informationi

    Entry nameiC4M5H3_ENTHI
    AccessioniPrimary (citable) accession number: C4M5H3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 7, 2009
    Last sequence update: July 7, 2009
    Last modified: October 1, 2014
    This is version 34 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3