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C4M5H3

- C4M5H3_ENTHI

UniProt

C4M5H3 - C4M5H3_ENTHI

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Protein

DNA ligase

Gene

EHI_111060

Organism
Entamoeba histolytica
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA biosynthetic process Source: InterPro
  2. DNA ligation involved in DNA repair Source: InterPro
  3. DNA recombination Source: UniProtKB-KW
  4. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
ORF Names:EHI_111060Imported
OrganismiEntamoeba histolyticaImported
Taxonomic identifieri5759 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaArchamoebaeEntamoebidaeEntamoeba
ProteomesiUP000001926: Partially assembled WGS sequence

Organism-specific databases

EuPathDBiAmoebaDB:EHI_111060.

Interactioni

Protein-protein interaction databases

STRINGi294381.C4M5H3.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

InParanoidiC4M5H3.
KOiK10747.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C4M5H3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKRQSSLSR FFKPAKRATV GGQNNGENKS DEKGNEKKKQ ESIEEKNQSL
60 70 80 90 100
QIKEEGNSFP EQKVKTLPFK GLADCFDALE NESGKLKKRE IYANYLKTVI
110 120 130 140 150
TICPNDLTDV LNLTTGQIAP TWEGKELGIG DAILKDVVKS VTGLKLSQLN
160 170 180 190 200
DKIKELGDIG IVAQNSKKNQ KLLVQPKPLT IQGVVLRMKE ILEADNSDIK
210 220 230 240 250
KNKITALLVA AIGNEIRFIL RILKGVFRIG FTDRSLPPAI AQAVCSIRKE
260 270 280 290 300
NNRIEELTEL ITNAVARVPS FQYLSEHITA NDPFEEFAKT NSVQLFIPFR
310 320 330 340 350
PMLAKPKKSI TDITSRFKFP FTAEYKYDGE RGQIHFNKNK IMVFTRNLEN
360 370 380 390 400
YTEKYPDVIE AVKDAVNPNI QSFIIDCEIV AFNRETNEFQ EFQILGRRAK
410 420 430 440 450
KGVSVHSIAI NVCVNVFDIV YLNGKDLMDK PLKERRDILH STFHEVSQRF
460 470 480 490 500
LFARFKNIEN EEDILPFFEE AINHRTEGLM CKTLIYDAEY IPDKRTDTWY
510 520 530 540 550
KLKKDYLNGL ADTVDLVPVG AWMGEGKRAG VYGAFLLACR DEDSGDFETV
560 570 580 590 600
TKVGTGFSDE ALQKLYEHLK TLECKEKKNV KHGDNLPDVW FEPKDVWEIK
610 620 630 640 650
GADLSLSLQY KAGTKLVNTE GRGVCLRFPR YIRSRDDKEV NDITTNKQIY
660 670 680
DLYKDQPSVR ETKDGQMKII NNDNEEESQE SEEKE
Length:685
Mass (Da):78,164
Last modified:July 7, 2009 - v1
Checksum:i594BA9A4207F93B7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS571279 Genomic DNA. Translation: EAL52210.1.
RefSeqiXP_657595.1. XM_652503.2.

Genome annotation databases

EnsemblProtistsirna_EHI_111060-1; rna_EHI_111060-1; EHI_111060.
GeneIDi3411902.
KEGGiehi:EHI_111060.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS571279 Genomic DNA. Translation: EAL52210.1 .
RefSeqi XP_657595.1. XM_652503.2.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 294381.C4M5H3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi rna_EHI_111060-1 ; rna_EHI_111060-1 ; EHI_111060 .
GeneIDi 3411902.
KEGGi ehi:EHI_111060.

Organism-specific databases

EuPathDBi AmoebaDB:EHI_111060.

Phylogenomic databases

InParanoidi C4M5H3.
KOi K10747.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProi IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 30459 / HM-1:IMSSImported.
  2. Lorenzi H., Amedeo P., Inman J., Schobel S., Caler E.
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: ATCC 30459 / HM-1:IMSSImported.

Entry informationi

Entry nameiC4M5H3_ENTHI
AccessioniPrimary (citable) accession number: C4M5H3
Entry historyi
Integrated into UniProtKB/TrEMBL: July 7, 2009
Last sequence update: July 7, 2009
Last modified: October 29, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3