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Protein
Submitted name:

Rho family GTPase

Gene

EHI_029020

Organism
Entamoeba histolytica
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW

GO - Biological processi

  1. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Ligandi

GTP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Rho family GTPaseImported
Gene namesi
ORF Names:EHI_029020Imported
OrganismiEntamoeba histolyticaImported
Taxonomic identifieri5759 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaArchamoebaeEntamoebidaeEntamoeba
ProteomesiUP000001926: Partially assembled WGS sequence

Organism-specific databases

EuPathDBiAmoebaDB:EHI_029020.

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: InterPro
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

MembraneSAAS annotation

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3REFX-ray1.95A/B1-191[»]
3REGX-ray1.80A/B1-191[»]
4DVGX-ray2.60A2-186[»]
ProteinModelPortaliC4M4W4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rho family.UniRule annotation

Phylogenomic databases

InParanoidiC4M4W4.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003578. Small_GTPase_Rho.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00174. RHO. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51420. RHO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C4M4W4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLAFSDMNTG AGKIENGKKA LKIVVVGDGA VGKTCLLLAF SKGEIPTAYV
60 70 80 90 100
PTVFENFSHV MKYKNEEFIL HLWDTAGQEE YDRLRPLSYA DSDVVLLCFA
110 120 130 140 150
VNNRTSFDNI STKWEPEIKH YIDTAKTVLV GLKVDLRKDG SDDVTKQEGD
160 170 180 190 200
DLCQKLGCVA YIEASSVAKI GLNEVFEKSV DCIFSNKPVP KASVTTQAKS
210
QESTQQKKKS KCLLQ
Length:215
Mass (Da):23,767
Last modified:July 7, 2009 - v1
Checksum:i5E346169F619617D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS571266 Genomic DNA. Translation: EAL49102.2.
RefSeqiXP_654488.2. XM_649396.2.

Genome annotation databases

EnsemblProtistsirna_EHI_029020-1; rna_EHI_029020-1; EHI_029020.
GeneIDi3408802.
KEGGiehi:EHI_029020.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS571266 Genomic DNA. Translation: EAL49102.2.
RefSeqiXP_654488.2. XM_649396.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3REFX-ray1.95A/B1-191[»]
3REGX-ray1.80A/B1-191[»]
4DVGX-ray2.60A2-186[»]
ProteinModelPortaliC4M4W4.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsirna_EHI_029020-1; rna_EHI_029020-1; EHI_029020.
GeneIDi3408802.
KEGGiehi:EHI_029020.

Organism-specific databases

EuPathDBiAmoebaDB:EHI_029020.

Phylogenomic databases

InParanoidiC4M4W4.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003578. Small_GTPase_Rho.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00174. RHO. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51420. RHO. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 30459 / HM-1:IMSSImported.
  2. Lorenzi H., Amedeo P., Inman J., Schobel S., Caler E.
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: ATCC 30459 / HM-1:IMSSImported.
  3. "Unique structural and nucleotide exchange features of the Rho1 GTPase of Entamoeba histolytica."
    Bosch D.E., Wittchen E.S., Qiu C., Burridge K., Siderovski D.P.
    J. Biol. Chem. 286:39236-39246(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 1-191.
  4. "Entamoeba histolytica Rho1 regulates actin polymerization through a divergent, diaphanous-related formin."
    Bosch D.E., Yang B., Siderovski D.P.
    Biochemistry 51:8791-8801(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 2-186.

Entry informationi

Entry nameiC4M4W4_ENTHI
AccessioniPrimary (citable) accession number: C4M4W4
Entry historyi
Integrated into UniProtKB/TrEMBL: July 7, 2009
Last sequence update: July 7, 2009
Last modified: January 7, 2015
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.