Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

C4M4W4

- C4M4W4_ENTHI

UniProt

C4M4W4 - C4M4W4_ENTHI

Protein
Submitted name:

Rho family GTPase

Gene

EHI_029020

Organism
Entamoeba histolytica
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (07 Jul 2009)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei29 – 291Sulfate 1; via amide nitrogenImported

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW

    GO - Biological processi

    1. small GTPase mediated signal transduction Source: InterPro

    Keywords - Ligandi

    GTP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Rho family GTPaseImported
    Gene namesi
    ORF Names:EHI_029020Imported
    OrganismiEntamoeba histolyticaImported
    Taxonomic identifieri5759 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaArchamoebaeEntamoebidaeEntamoeba
    ProteomesiUP000001926: Partially assembled WGS sequence

    Organism-specific databases

    EuPathDBiAmoebaDB:EHI_029020.

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: InterPro
    2. membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    MembraneSAAS annotation

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3REFX-ray1.95A/B1-191[»]
    3REGX-ray1.80A/B1-191[»]
    4DVGX-ray2.60A2-186[»]
    ProteinModelPortaliC4M4W4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni171 – 1744Sulfate 2 bindingImported

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Rho family.UniRule annotation

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003578. Small_GTPase_Rho.
    [Graphical view]
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00174. RHO. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51420. RHO. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C4M4W4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLAFSDMNTG AGKIENGKKA LKIVVVGDGA VGKTCLLLAF SKGEIPTAYV    50
    PTVFENFSHV MKYKNEEFIL HLWDTAGQEE YDRLRPLSYA DSDVVLLCFA 100
    VNNRTSFDNI STKWEPEIKH YIDTAKTVLV GLKVDLRKDG SDDVTKQEGD 150
    DLCQKLGCVA YIEASSVAKI GLNEVFEKSV DCIFSNKPVP KASVTTQAKS 200
    QESTQQKKKS KCLLQ 215
    Length:215
    Mass (Da):23,767
    Last modified:July 7, 2009 - v1
    Checksum:i5E346169F619617D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS571266 Genomic DNA. Translation: EAL49102.2.
    RefSeqiXP_654488.2. XM_649396.2.

    Genome annotation databases

    EnsemblProtistsirna_EHI_029020-1; rna_EHI_029020-1; EHI_029020.
    GeneIDi3408802.
    KEGGiehi:EHI_029020.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS571266 Genomic DNA. Translation: EAL49102.2 .
    RefSeqi XP_654488.2. XM_649396.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3REF X-ray 1.95 A/B 1-191 [» ]
    3REG X-ray 1.80 A/B 1-191 [» ]
    4DVG X-ray 2.60 A 2-186 [» ]
    ProteinModelPortali C4M4W4.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi rna_EHI_029020-1 ; rna_EHI_029020-1 ; EHI_029020 .
    GeneIDi 3408802.
    KEGGi ehi:EHI_029020.

    Organism-specific databases

    EuPathDBi AmoebaDB:EHI_029020.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003578. Small_GTPase_Rho.
    [Graphical view ]
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00174. RHO. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51420. RHO. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 30459 / HM-1:IMSSImported.
    2. Lorenzi H., Amedeo P., Inman J., Schobel S., Caler E.
      Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: ATCC 30459 / HM-1:IMSSImported.
    3. "Unique structural and nucleotide exchange features of the Rho1 GTPase of Entamoeba histolytica."
      Bosch D.E., Wittchen E.S., Qiu C., Burridge K., Siderovski D.P.
      J. Biol. Chem. 286:39236-39246(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 1-191.
    4. "Entamoeba histolytica Rho1 regulates actin polymerization through a divergent, diaphanous-related formin."
      Bosch D.E., Yang B., Siderovski D.P.
      Biochemistry 51:8791-8801(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 2-186.

    Entry informationi

    Entry nameiC4M4W4_ENTHI
    AccessioniPrimary (citable) accession number: C4M4W4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 7, 2009
    Last sequence update: July 7, 2009
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3