C4M4W4 (C4M4W4_ENTHI) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Rho family GTPase EMBL EAL49102.2

Gene names

ORF Names:

EHI_029020 EMBL EAL49102.2

Organism

Entamoeba histolytica [Reference proteome]

Taxonomic identifier

5759 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Amoebozoa › Archamoebae › Entamoebidae › Entamoeba

Protein attributes

Sequence length	215 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the small GTPase superfamily. Rho family. RuleBase RU003317

Ontologies

Keywords
Cellular component	Membrane SAAS SAAS003578
Ligand	GTP-binding RuleBase RU003312 SAAS SAAS003578 Nucleotide-binding
Technical term	3D-structure PDB 3REF PDB 3REG PDB 4DVG Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	intracellular Inferred from electronic annotation. Source: InterPro membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	C4M4W4 [UniParc]. Last modified July 7, 2009. Version 1. Checksum: 5E346169F619617D	FASTA	215	23,767
	10 20 30 40 50 60 MLAFSDMNTG AGKIENGKKA LKIVVVGDGA VGKTCLLLAF SKGEIPTAYV PTVFENFSHV 70 80 90 100 110 120 MKYKNEEFIL HLWDTAGQEE YDRLRPLSYA DSDVVLLCFA VNNRTSFDNI STKWEPEIKH 130 140 150 160 170 180 YIDTAKTVLV GLKVDLRKDG SDDVTKQEGD DLCQKLGCVA YIEASSVAKI GLNEVFEKSV 190 200 210 DCIFSNKPVP KASVTTQAKS QESTQQKKKS KCLLQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome of the protist parasite Entamoeba histolytica." Loftus B.J., Anderson I., Davies R., Alsmark U.C., Samuelson J., Amedeo P., Roncaglia P., Berriman M., Hirt R.P., Mann B.J., Nozaki T., Suh B., Pop M., Duchene M., Ackers J., Tannich E., Leippe M., Hofer M. , Bruchhaus I., Willhoeft U., Bhattacharya A., Chillingworth T., Churcher C.M., Hance Z., Harris B., Harris D., Jagels K., Moule S., Mungall K.L., Ormond D., Squares R., Whitehead S., Quail M.A., Rabbinowitsch E., Norbertczak H., Price C., Wang Z., Guillen N., Gilchrist C., Stroup S.E., Bhattacharya S., Lohia A., Foster P.G., Sicheritz-Ponten T., Weber C., Singh U., Mukherjee C., El-Sayed N.M.A., Petri W.A., Clark C.G., Embley T.M., Barrell B.G., Fraser C.M., Hall N. Nature 433:865-868(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 30459 / HM-1:IMSS.
[2]	Lorenzi H., Amedeo P., Inman J., Schobel S., Caler E. Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 30459 / HM-1:IMSS.
[3]	"Unique structural and nucleotide exchange features of the Rho1 GTPase of Entamoeba histolytica." Bosch D.E., Wittchen E.S., Qiu C., Burridge K., Siderovski D.P. J. Biol. Chem. 286:39236-39246(2011) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 1-191.
[4]	"Entamoeba histolytica Rho1 regulates actin polymerization through a divergent, diaphanous-related formin." Bosch D.E., Yang B., Siderovski D.P. Biochemistry 51:8791-8801(2012) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 2-186.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

DS571266 Genomic DNA. Translation: EAL49102.2.

RefSeq

XP_654488.2. XM_649396.2.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3REF	X-ray	1.95	A/B	1-191	[»]
3REG	X-ray	1.80	A/B	1-191	[»]

ProteinModelPortal

C4M4W4.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblProtists

rna_EHI_029020-1; rna_EHI_029020-1; EHI_029020.

GeneID

3408802.

KEGG

ehi:EHI_029020.

Organism-specific databases

EuPathDB

AmoebaDB:EHI_029020.

Phylogenomic databases

ProtClustDB

CLSZ2735146.

Family and domain databases

InterPro

IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003578. Small_GTPase_Rho.
[Graphical view]

Pfam

PF00071. Ras. 1 hit.
[Graphical view]

PRINTS

PR00449. RASTRNSFRMNG.

SMART

SM00174. RHO. 1 hit.
[Graphical view]

TIGRFAMs

TIGR00231. small_GTP. 1 hit.

PROSITE

PS51420. RHO. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

C4M4W4_ENTHI

Accession

Primary (citable) accession number: C4M4W4

Entry history

Integrated into UniProtKB/TrEMBL:	July 7, 2009
Last sequence update:	July 7, 2009
Last modified:	May 1, 2013
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)