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C4M4W4

- C4M4W4_ENTHI

UniProt

C4M4W4 - C4M4W4_ENTHI

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Protein
Submitted name: Rho family GTPase
Gene
EHI_029020
Organism
Entamoeba histolytica
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei29 – 291Sulfate 1; via amide nitrogenImported

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW

GO - Biological processi

  1. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Ligandi

GTP-bindingUniRule annotationSAAS annotations, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Rho family GTPaseImported
Gene namesi
ORF Names:EHI_029020Imported
OrganismiEntamoeba histolytica
Taxonomic identifieri5759 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaArchamoebaeEntamoebidaeEntamoeba
ProteomesiUP000001926: Partially assembled WGS sequence

Organism-specific databases

EuPathDBiAmoebaDB:EHI_029020.

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: InterPro
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

MembraneSAAS annotations

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3REFX-ray1.95A/B1-191[»]
3REGX-ray1.80A/B1-191[»]
4DVGX-ray2.60A2-186[»]
ProteinModelPortaliC4M4W4.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni171 – 1744Sulfate 2 bindingImported

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rho family.UniRule annotation

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003578. Small_GTPase_Rho.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00174. RHO. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51420. RHO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C4M4W4-1 [UniParc]FASTAAdd to Basket

« Hide

MLAFSDMNTG AGKIENGKKA LKIVVVGDGA VGKTCLLLAF SKGEIPTAYV    50
PTVFENFSHV MKYKNEEFIL HLWDTAGQEE YDRLRPLSYA DSDVVLLCFA 100
VNNRTSFDNI STKWEPEIKH YIDTAKTVLV GLKVDLRKDG SDDVTKQEGD 150
DLCQKLGCVA YIEASSVAKI GLNEVFEKSV DCIFSNKPVP KASVTTQAKS 200
QESTQQKKKS KCLLQ 215
Length:215
Mass (Da):23,767
Last modified:July 7, 2009 - v1
Checksum:i5E346169F619617D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS571266 Genomic DNA. Translation: EAL49102.2.
RefSeqiXP_654488.2. XM_649396.2.

Genome annotation databases

EnsemblProtistsirna_EHI_029020-1; rna_EHI_029020-1; EHI_029020.
GeneIDi3408802.
KEGGiehi:EHI_029020.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS571266 Genomic DNA. Translation: EAL49102.2 .
RefSeqi XP_654488.2. XM_649396.2.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3REF X-ray 1.95 A/B 1-191 [» ]
3REG X-ray 1.80 A/B 1-191 [» ]
4DVG X-ray 2.60 A 2-186 [» ]
ProteinModelPortali C4M4W4.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi rna_EHI_029020-1 ; rna_EHI_029020-1 ; EHI_029020 .
GeneIDi 3408802.
KEGGi ehi:EHI_029020.

Organism-specific databases

EuPathDBi AmoebaDB:EHI_029020.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003578. Small_GTPase_Rho.
[Graphical view ]
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00174. RHO. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51420. RHO. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 30459 / HM-1:IMSS.
  2. Lorenzi H., Amedeo P., Inman J., Schobel S., Caler E.
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: ATCC 30459 / HM-1:IMSS.
  3. "Unique structural and nucleotide exchange features of the Rho1 GTPase of Entamoeba histolytica."
    Bosch D.E., Wittchen E.S., Qiu C., Burridge K., Siderovski D.P.
    J. Biol. Chem. 286:39236-39246(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 1-191.
  4. "Entamoeba histolytica Rho1 regulates actin polymerization through a divergent, diaphanous-related formin."
    Bosch D.E., Yang B., Siderovski D.P.
    Biochemistry 51:8791-8801(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 2-186.

Entry informationi

Entry nameiC4M4W4_ENTHI
AccessioniPrimary (citable) accession number: C4M4W4
Entry historyi
Integrated into UniProtKB/TrEMBL: July 7, 2009
Last sequence update: July 7, 2009
Last modified: September 3, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteome

External Data

Dasty 3

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