Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

C4M4W4 (C4M4W4_ENTHI) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
ORF Names:EHI_029020 EMBL EAL49102.2
OrganismEntamoeba histolytica [Reference proteome]
Taxonomic identifier5759 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaArchamoebaeEntamoebidaeEntamoeba

Protein attributes

Sequence length215 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the small GTPase superfamily. Rho family. RuleBase RU003317

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region171 – 1744Sulfate 2 binding PDB 3REF

Sites

Binding site291Sulfate 1; via amide nitrogen PDB 3REF

Sequences

Sequence LengthMass (Da)Tools
C4M4W4 [UniParc].

Last modified July 7, 2009. Version 1.
Checksum: 5E346169F619617D

FASTA21523,767
        10         20         30         40         50         60 
MLAFSDMNTG AGKIENGKKA LKIVVVGDGA VGKTCLLLAF SKGEIPTAYV PTVFENFSHV 

        70         80         90        100        110        120 
MKYKNEEFIL HLWDTAGQEE YDRLRPLSYA DSDVVLLCFA VNNRTSFDNI STKWEPEIKH 

       130        140        150        160        170        180 
YIDTAKTVLV GLKVDLRKDG SDDVTKQEGD DLCQKLGCVA YIEASSVAKI GLNEVFEKSV 

       190        200        210 
DCIFSNKPVP KASVTTQAKS QESTQQKKKS KCLLQ 

« Hide

References

« Hide 'large scale' references
[1]"The genome of the protist parasite Entamoeba histolytica."
Loftus B.J., Anderson I., Davies R., Alsmark U.C., Samuelson J., Amedeo P., Roncaglia P., Berriman M., Hirt R.P., Mann B.J., Nozaki T., Suh B., Pop M., Duchene M., Ackers J., Tannich E., Leippe M., Hofer M. expand/collapse author list , Bruchhaus I., Willhoeft U., Bhattacharya A., Chillingworth T., Churcher C.M., Hance Z., Harris B., Harris D., Jagels K., Moule S., Mungall K.L., Ormond D., Squares R., Whitehead S., Quail M.A., Rabbinowitsch E., Norbertczak H., Price C., Wang Z., Guillen N., Gilchrist C., Stroup S.E., Bhattacharya S., Lohia A., Foster P.G., Sicheritz-Ponten T., Weber C., Singh U., Mukherjee C., El-Sayed N.M.A., Petri W.A., Clark C.G., Embley T.M., Barrell B.G., Fraser C.M., Hall N.
Nature 433:865-868(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 30459 / HM-1:IMSS.
[2]Lorenzi H., Amedeo P., Inman J., Schobel S., Caler E.
Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 30459 / HM-1:IMSS.
[3]"Unique structural and nucleotide exchange features of the Rho1 GTPase of Entamoeba histolytica."
Bosch D.E., Wittchen E.S., Qiu C., Burridge K., Siderovski D.P.
J. Biol. Chem. 286:39236-39246(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 1-191 IN COMPLEX WITH SULFATE.
[4]"Entamoeba histolytica Rho1 regulates actin polymerization through a divergent, diaphanous-related formin."
Bosch D.E., Yang B., Siderovski D.P.
Biochemistry 51:8791-8801(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 2-186.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DS571266 Genomic DNA. Translation: EAL49102.2.
RefSeqXP_654488.2. XM_649396.2.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3REFX-ray1.95A/B1-191[»]
3REGX-ray1.80A/B1-191[»]
4DVGX-ray2.60A2-186[»]
ProteinModelPortalC4M4W4.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsrna_EHI_029020-1; rna_EHI_029020-1; EHI_029020.
GeneID3408802.
KEGGehi:EHI_029020.

Organism-specific databases

EuPathDBAmoebaDB:EHI_029020.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003578. Small_GTPase_Rho.
[Graphical view]
PfamPF00071. Ras. 1 hit.
[Graphical view]
PRINTSPR00449. RASTRNSFRMNG.
SMARTSM00174. RHO. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00231. small_GTP. 1 hit.
PROSITEPS51420. RHO. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC4M4W4_ENTHI
AccessionPrimary (citable) accession number: C4M4W4
Entry history
Integrated into UniProtKB/TrEMBL: July 7, 2009
Last sequence update: July 7, 2009
Last modified: June 11, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)