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C4M483

- C4M483_ENTHI

UniProt

C4M483 - C4M483_ENTHI

Protein
Submitted name:

G protein alpha subunit, putative

Gene

EHI_140350

Organism
Entamoeba histolytica
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (07 Jul 2009)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. GTPase activity Source: InterPro
    2. GTP binding Source: UniProtKB-KW
    3. signal transducer activity Source: InterPro

    GO - Biological processi

    1. G-protein coupled receptor signaling pathway Source: InterPro

    Keywords - Ligandi

    GTP-bindingSAAS annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    G protein alpha subunit, putativeImported
    Gene namesi
    ORF Names:EHI_140350Imported
    OrganismiEntamoeba histolyticaImported
    Taxonomic identifieri5759 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaArchamoebaeEntamoebidaeEntamoeba
    ProteomesiUP000001926: Partially assembled WGS sequence

    Organism-specific databases

    EuPathDBiAmoebaDB:EHI_140350.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-60100N.
    STRINGi294381.C4M483.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4FIDX-ray2.62A/B22-358[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    KOiK04640.

    Family and domain databases

    Gene3Di1.10.400.10. 1 hit.
    3.40.50.300. 2 hits.
    InterProiIPR001019. Gprotein_alpha_su.
    IPR011025. GproteinA_insert.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PANTHERiPTHR10218. PTHR10218. 1 hit.
    PfamiPF00503. G-alpha. 1 hit.
    [Graphical view]
    PRINTSiPR00318. GPROTEINA.
    SMARTiSM00275. G_alpha. 1 hit.
    [Graphical view]
    SUPFAMiSSF47895. SSF47895. 1 hit.
    SSF52540. SSF52540. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    C4M483-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGCGQSKDNS IDKQIVEMAK SKPITVMLLG SGESGKSTIA KQLKILFGGG    50
    FPEQERATHK SSICSNVVTC MRTLIEQSAI LNHPMKYQPK SKEFTTEDPV 100
    TLPFSPELVG DVEALWADEG IQATYEESAK FQLPDCAKYL FENVKRIAME 150
    DYVPTEEDLI HNRTKTTGIH EYDFVVKDIP FHLIDVGGQR SERKKWVSFF 200
    SDVDCAIFVT SLAEYDMKLY EDGNTSRLTE SIAVFKDIMT NEFLKGAVKL 250
    IFLNKMDLFE EKLTKVPLNT IFPEYTGGDN AVMGAQYIQQ LFTGKLQTEE 300
    MNISGADGTA NIEGAVNEKV YTNPTNATDG SNIKRVFMLA VDVIMKNMAA 350
    NGKMRPTK 358
    Length:358
    Mass (Da):39,947
    Last modified:July 7, 2009 - v1
    Checksum:i49A45E19F5364765
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK420232 mRNA. Translation: BAN38853.1.
    AK421528 mRNA. Translation: BAN40068.1.
    DS571254 Genomic DNA. Translation: EAL46350.2.
    RefSeqiXP_651737.2. XM_646645.2.

    Genome annotation databases

    EnsemblProtistsirna_EHI_140350-1; rna_EHI_140350-1; EHI_140350.
    GeneIDi3406047.
    KEGGiehi:EHI_140350.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK420232 mRNA. Translation: BAN38853.1 .
    AK421528 mRNA. Translation: BAN40068.1 .
    DS571254 Genomic DNA. Translation: EAL46350.2 .
    RefSeqi XP_651737.2. XM_646645.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4FID X-ray 2.62 A/B 22-358 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-60100N.
    STRINGi 294381.C4M483.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi rna_EHI_140350-1 ; rna_EHI_140350-1 ; EHI_140350 .
    GeneIDi 3406047.
    KEGGi ehi:EHI_140350.

    Organism-specific databases

    EuPathDBi AmoebaDB:EHI_140350.

    Phylogenomic databases

    KOi K04640.

    Family and domain databases

    Gene3Di 1.10.400.10. 1 hit.
    3.40.50.300. 2 hits.
    InterProi IPR001019. Gprotein_alpha_su.
    IPR011025. GproteinA_insert.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    PANTHERi PTHR10218. PTHR10218. 1 hit.
    Pfami PF00503. G-alpha. 1 hit.
    [Graphical view ]
    PRINTSi PR00318. GPROTEINA.
    SMARTi SM00275. G_alpha. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47895. SSF47895. 1 hit.
    SSF52540. SSF52540. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 30459 / HM-1:IMSSImported.
    2. Lorenzi H., Amedeo P., Inman J., Schobel S., Caler E.
      Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: ATCC 30459 / HM-1:IMSSImported.
    3. "Heterotrimeric G-protein signaling is critical to pathogenic processes in Entamoeba histolytica."
      Bosch D.E., Kimple A.J., Muller R.E., Giguere P.M., Machius M., Willard F.S., Temple B.R., Siderovski D.P.
      PLoS Pathog. 8:e1003040-e1003040(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.62 ANGSTROMS) OF 22-358.
    4. "Short 5' UTR of Entamoeba genes."
      Hiranuka K., Kumagai M., Wakaguri H., Suzuki Y., Sugano S., Watanabe J., Makioka A.
      Submitted (JUN-2012) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: HM-1:IMSSImported.

    Entry informationi

    Entry nameiC4M483_ENTHI
    AccessioniPrimary (citable) accession number: C4M483
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 7, 2009
    Last sequence update: July 7, 2009
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3