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Protein
Submitted name:

G protein alpha subunit, putative

Gene

EHI_140350

Organism
Entamoeba histolytica
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. GTPase activity Source: InterPro
  2. GTP binding Source: UniProtKB-KW
  3. signal transducer activity Source: InterPro

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Ligandi

GTP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
G protein alpha subunit, putativeImported
Gene namesi
ORF Names:EHI_140350Imported
OrganismiEntamoeba histolyticaImported
Taxonomic identifieri5759 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaArchamoebaeEntamoebidaeEntamoeba
ProteomesiUP000001926: Partially assembled WGS sequence

Organism-specific databases

EuPathDBiAmoebaDB:EHI_140350.

Interactioni

Protein-protein interaction databases

DIPiDIP-60100N.
STRINGi294381.C4M483.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4FIDX-ray2.62A/B22-358[»]
ProteinModelPortaliC4M483.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

KOiK04640.

Family and domain databases

Gene3Di1.10.400.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR001019. Gprotein_alpha_su.
IPR011025. GproteinA_insert.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10218. PTHR10218. 1 hit.
PfamiPF00503. G-alpha. 1 hit.
[Graphical view]
PRINTSiPR00318. GPROTEINA.
SMARTiSM00275. G_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF47895. SSF47895. 1 hit.
SSF52540. SSF52540. 2 hits.

Sequencei

Sequence statusi: Complete.

C4M483-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGCGQSKDNS IDKQIVEMAK SKPITVMLLG SGESGKSTIA KQLKILFGGG
60 70 80 90 100
FPEQERATHK SSICSNVVTC MRTLIEQSAI LNHPMKYQPK SKEFTTEDPV
110 120 130 140 150
TLPFSPELVG DVEALWADEG IQATYEESAK FQLPDCAKYL FENVKRIAME
160 170 180 190 200
DYVPTEEDLI HNRTKTTGIH EYDFVVKDIP FHLIDVGGQR SERKKWVSFF
210 220 230 240 250
SDVDCAIFVT SLAEYDMKLY EDGNTSRLTE SIAVFKDIMT NEFLKGAVKL
260 270 280 290 300
IFLNKMDLFE EKLTKVPLNT IFPEYTGGDN AVMGAQYIQQ LFTGKLQTEE
310 320 330 340 350
MNISGADGTA NIEGAVNEKV YTNPTNATDG SNIKRVFMLA VDVIMKNMAA

NGKMRPTK
Length:358
Mass (Da):39,947
Last modified:July 7, 2009 - v1
Checksum:i49A45E19F5364765
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK420232 mRNA. Translation: BAN38853.1.
AK421528 mRNA. Translation: BAN40068.1.
DS571254 Genomic DNA. Translation: EAL46350.2.
RefSeqiXP_651737.2. XM_646645.2.

Genome annotation databases

EnsemblProtistsirna_EHI_140350-1; rna_EHI_140350-1; EHI_140350.
GeneIDi3406047.
KEGGiehi:EHI_140350.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK420232 mRNA. Translation: BAN38853.1.
AK421528 mRNA. Translation: BAN40068.1.
DS571254 Genomic DNA. Translation: EAL46350.2.
RefSeqiXP_651737.2. XM_646645.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4FIDX-ray2.62A/B22-358[»]
ProteinModelPortaliC4M483.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60100N.
STRINGi294381.C4M483.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsirna_EHI_140350-1; rna_EHI_140350-1; EHI_140350.
GeneIDi3406047.
KEGGiehi:EHI_140350.

Organism-specific databases

EuPathDBiAmoebaDB:EHI_140350.

Phylogenomic databases

KOiK04640.

Family and domain databases

Gene3Di1.10.400.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR001019. Gprotein_alpha_su.
IPR011025. GproteinA_insert.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10218. PTHR10218. 1 hit.
PfamiPF00503. G-alpha. 1 hit.
[Graphical view]
PRINTSiPR00318. GPROTEINA.
SMARTiSM00275. G_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF47895. SSF47895. 1 hit.
SSF52540. SSF52540. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 30459 / HM-1:IMSSImported.
  2. Lorenzi H., Amedeo P., Inman J., Schobel S., Caler E.
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: ATCC 30459 / HM-1:IMSSImported.
  3. "Heterotrimeric G-protein signaling is critical to pathogenic processes in Entamoeba histolytica."
    Bosch D.E., Kimple A.J., Muller R.E., Giguere P.M., Machius M., Willard F.S., Temple B.R., Siderovski D.P.
    PLoS Pathog. 8:e1003040-e1003040(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.62 ANGSTROMS) OF 22-358.
  4. "Short 5' UTR of Entamoeba genes."
    Hiranuka K., Kumagai M., Wakaguri H., Suzuki Y., Sugano S., Watanabe J., Makioka A.
    Submitted (JUN-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: HM-1:IMSSImported.

Entry informationi

Entry nameiC4M483_ENTHI
AccessioniPrimary (citable) accession number: C4M483
Entry historyi
Integrated into UniProtKB/TrEMBL: July 7, 2009
Last sequence update: July 7, 2009
Last modified: February 4, 2015
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.