C4M483 (C4M483_ENTHI) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
G protein alpha subunit, putative EMBL EAL46350.2

Gene names

ORF Names:

EHI_140350 EMBL EAL46350.2

Organism

Entamoeba histolytica [Reference proteome]

Taxonomic identifier

5759 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Amoebozoa › Archamoebae › Entamoebidae › Entamoeba

Protein attributes

Sequence length	358 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Ligand	GTP-binding SAAS SAAS011025 Nucleotide-binding
Technical term	3D-structure PDB 4FID Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	G-protein coupled receptor signaling pathway Inferred from electronic annotation. Source: InterPro GTP catabolic process Inferred from electronic annotation. Source: GOC
Molecular_function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activity Inferred from electronic annotation. Source: InterPro signal transducer activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	C4M483 [UniParc]. Last modified July 7, 2009. Version 1. Checksum: 49A45E19F5364765	FASTA	358	39,947
	10 20 30 40 50 60 MGCGQSKDNS IDKQIVEMAK SKPITVMLLG SGESGKSTIA KQLKILFGGG FPEQERATHK 70 80 90 100 110 120 SSICSNVVTC MRTLIEQSAI LNHPMKYQPK SKEFTTEDPV TLPFSPELVG DVEALWADEG 130 140 150 160 170 180 IQATYEESAK FQLPDCAKYL FENVKRIAME DYVPTEEDLI HNRTKTTGIH EYDFVVKDIP 190 200 210 220 230 240 FHLIDVGGQR SERKKWVSFF SDVDCAIFVT SLAEYDMKLY EDGNTSRLTE SIAVFKDIMT 250 260 270 280 290 300 NEFLKGAVKL IFLNKMDLFE EKLTKVPLNT IFPEYTGGDN AVMGAQYIQQ LFTGKLQTEE 310 320 330 340 350 MNISGADGTA NIEGAVNEKV YTNPTNATDG SNIKRVFMLA VDVIMKNMAA NGKMRPTK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome of the protist parasite Entamoeba histolytica." Loftus B.J., Anderson I., Davies R., Alsmark U.C., Samuelson J., Amedeo P., Roncaglia P., Berriman M., Hirt R.P., Mann B.J., Nozaki T., Suh B., Pop M., Duchene M., Ackers J., Tannich E., Leippe M., Hofer M. , Bruchhaus I., Willhoeft U., Bhattacharya A., Chillingworth T., Churcher C.M., Hance Z., Harris B., Harris D., Jagels K., Moule S., Mungall K.L., Ormond D., Squares R., Whitehead S., Quail M.A., Rabbinowitsch E., Norbertczak H., Price C., Wang Z., Guillen N., Gilchrist C., Stroup S.E., Bhattacharya S., Lohia A., Foster P.G., Sicheritz-Ponten T., Weber C., Singh U., Mukherjee C., El-Sayed N.M.A., Petri W.A., Clark C.G., Embley T.M., Barrell B.G., Fraser C.M., Hall N. Nature 433:865-868(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 30459 / HM-1:IMSS.
[2]	Lorenzi H., Amedeo P., Inman J., Schobel S., Caler E. Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 30459 / HM-1:IMSS.
[3]	"Heterotrimeric G-protein signaling is critical to pathogenic processes in Entamoeba histolytica." Bosch D.E., Kimple A.J., Muller R.E., Giguere P.M., Machius M., Willard F.S., Temple B.R., Siderovski D.P. PLoS Pathog. 8:e1003040-e1003040(2012) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.62 ANGSTROMS) OF 22-358.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

DS571254 Genomic DNA. Translation: EAL46350.2.

RefSeq

XP_651737.2. XM_646645.2.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
4FID	X-ray	2.62	A/B	22-358	[»]

ProteinModelPortal

C4M483.

ModBase

Search...

Protein-protein interaction databases

STRING

294381.C4M483.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblProtists

rna_EHI_140350-1; rna_EHI_140350-1; EHI_140350.

GeneID

3406047.

KEGG

ehi:EHI_140350.

Organism-specific databases

EuPathDB

AmoebaDB:EHI_140350.

Phylogenomic databases

ProtClustDB

CLSZ2735494.

Family and domain databases

Gene3D

1.10.400.10. 1 hit.

InterPro

IPR001019. Gprotein_alpha_su.
IPR011025. GproteinA_insert.
[Graphical view]

PANTHER

PTHR10218. PTHR10218. 1 hit.

Pfam

PF00503. G-alpha. 1 hit.
[Graphical view]

PRINTS

PR00318. GPROTEINA.

SMART

SM00275. G_alpha. 1 hit.
[Graphical view]

SUPFAM

SSF47895. Transducn_insert. 1 hit.

ProtoNet

Search...

Entry information

Entry name

C4M483_ENTHI

Accession

Primary (citable) accession number: C4M483

Entry history

Integrated into UniProtKB/TrEMBL:	July 7, 2009
Last sequence update:	July 7, 2009
Last modified:	May 1, 2013
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)