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C4M1C3

- C4M1C3_ENTHI

UniProt

C4M1C3 - C4M1C3_ENTHI

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Protein

Probable acetate kinase

Gene

EHI_170010

Organism
Entamoeba histolytica
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + acetate = ADP + acetyl phosphate.UniRule annotation

Cofactori

Note: Mg(2+).UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi8 – 81MagnesiumUniRule annotation
Binding sitei85 – 851SubstrateUniRule annotation
Active sitei142 – 1421Proton donor/acceptorUniRule annotation
Sitei172 – 1721Transition state stabilizerUniRule annotation
Sitei232 – 2321Transition state stabilizerUniRule annotation
Metal bindingi378 – 3781MagnesiumUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi272 – 2743ATPUniRule annotation

GO - Molecular functioni

  1. acetate kinase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-KW
  3. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. acetyl-CoA biosynthetic process Source: UniProtKB-UniPathway
  2. organic acid metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationImported, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00340; UER00458.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable acetate kinaseUniRule annotation (EC:2.7.2.1UniRule annotation)
Alternative name(s):
AcetokinaseUniRule annotation
Gene namesi
ORF Names:EHI_170010Imported
OrganismiEntamoeba histolyticaImported
Taxonomic identifieri5759 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaArchamoebaeEntamoebidaeEntamoeba
ProteomesiUP000001926: Partially assembled WGS sequence

Organism-specific databases

EuPathDBiAmoebaDB:EHI_170010.

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: InterPro
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi294381.C4M1C3.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4H0OX-ray2.40A/B1-392[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetokinase family.UniRule annotation

Phylogenomic databases

InParanoidiC4M1C3.
KOiK00925.

Family and domain databases

HAMAPiMF_00020. Acetate_kinase.
InterProiIPR004372. Ac/Proprionate_kinase.
IPR000890. Aliphatic_acid_kin_short-chain.
[Graphical view]
PANTHERiPTHR21060. PTHR21060. 1 hit.
PfamiPF00871. Acetate_kinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000722. Acetate_prop_kin. 1 hit.
PRINTSiPR00471. ACETATEKNASE.
TIGRFAMsiTIGR00016. ackA. 1 hit.

Sequencei

Sequence statusi: Complete.

C4M1C3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSNVLIFNVG SSSLTYKVFC SDNIVCSGKS NRVNVTGTEK PFIEHHLNGQ
60 70 80 90 100
IIKIETPILN HPQAAKLIIQ FLKENHISIA FVGHRFVHGG SYFKKSAVID
110 120 130 140 150
EVVLKELKEC LPLAPIHNPS SFGVIEISMK ELPTTRQYVA IDTAFHSTIS
160 170 180 190 200
QAERTYAIPQ PYQSQYLKFG FHGLSYEYVI NSLKNVIDVS HSKIIACHLG
210 220 230 240 250
TGGSSCCGIV NGKSFDTSMG NSTLAGLVMS TRCGDIDPTI PIDMIQQVGI
260 270 280 290 300
EKVVDILNKK SGLLGVSELS SDMRDILHEI ETRGPKAKTC QLAFDVYIKQ
310 320 330 340 350
LAKTIGGLMV EIGGLDLLVF TDQMGLEVWQ VRKAICDKMK FLGIELDDSL
360 370 380 390
NEKSMGKKIE FLTMPSSKVQ VCVAPNDEEL VILQKGKELF QF
Length:392
Mass (Da):43,247
Last modified:July 7, 2009 - v1
Checksum:i55ED2FE3B0836FF1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS571207 Genomic DNA. Translation: EAL50605.1.
RefSeqiXP_655990.1. XM_650898.1.

Genome annotation databases

EnsemblProtistsirna_EHI_170010-1; rna_EHI_170010-1; EHI_170010.
GeneIDi3410291.
KEGGiehi:EHI_170010.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS571207 Genomic DNA. Translation: EAL50605.1 .
RefSeqi XP_655990.1. XM_650898.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4H0O X-ray 2.40 A/B 1-392 [» ]
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 294381.C4M1C3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi rna_EHI_170010-1 ; rna_EHI_170010-1 ; EHI_170010 .
GeneIDi 3410291.
KEGGi ehi:EHI_170010.

Organism-specific databases

EuPathDBi AmoebaDB:EHI_170010.

Phylogenomic databases

InParanoidi C4M1C3.
KOi K00925.

Enzyme and pathway databases

UniPathwayi UPA00340 ; UER00458 .

Family and domain databases

HAMAPi MF_00020. Acetate_kinase.
InterProi IPR004372. Ac/Proprionate_kinase.
IPR000890. Aliphatic_acid_kin_short-chain.
[Graphical view ]
PANTHERi PTHR21060. PTHR21060. 1 hit.
Pfami PF00871. Acetate_kinase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000722. Acetate_prop_kin. 1 hit.
PRINTSi PR00471. ACETATEKNASE.
TIGRFAMsi TIGR00016. ackA. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 30459 / HM-1:IMSSImported.
  2. Lorenzi H., Amedeo P., Inman J., Schobel S., Caler E.
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: ATCC 30459 / HM-1:IMSSImported.
  3. "Crystal structures of acetate kinases from the eukaryotic pathogens Entamoeba histolytica and Cryptococcus neoformans."
    Thaker T.M., Tanabe M., Fowler M.L., Preininger A.M., Ingram-Smith C., Smith K.S., Iverson T.M.
    J. Struct. Biol. 181:185-189(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS).

Entry informationi

Entry nameiC4M1C3_ENTHI
AccessioniPrimary (citable) accession number: C4M1C3
Entry historyi
Integrated into UniProtKB/TrEMBL: July 7, 2009
Last sequence update: July 7, 2009
Last modified: November 26, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteomeImported

External Data

Dasty 3