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C4M1C3 (C4M1C3_ENTHI) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable acetate kinase HAMAP-Rule MF_03131

EC=2.7.2.1 HAMAP-Rule MF_03131
Alternative name(s):
Acetokinase HAMAP-Rule MF_03131
Gene names
ORF Names:EHI_170010 EMBL EAL50605.1
OrganismEntamoeba histolytica [Reference proteome]
Taxonomic identifier5759 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaArchamoebaeEntamoebidaeEntamoeba

Protein attributes

Sequence length392 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

ATP + acetate = ADP + acetyl phosphate. HAMAP-Rule MF_03131

Cofactor

Mg2+ By similarity. HAMAP-Rule MF_03131

Pathway

Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2. HAMAP-Rule MF_03131

Sequence similarities

Belongs to the acetokinase family. HAMAP-Rule MF_03131

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding272 – 2743ATP By similarity HAMAP-Rule MF_03131

Sites

Active site1421Proton donor/acceptor By similarity HAMAP-Rule MF_03131
Metal binding81Magnesium By similarity HAMAP-Rule MF_03131
Metal binding3781Magnesium By similarity HAMAP-Rule MF_03131
Binding site851Substrate By similarity HAMAP-Rule MF_03131
Site1721Transition state stabilizer By similarity HAMAP-Rule MF_03131
Site2321Transition state stabilizer By similarity HAMAP-Rule MF_03131

Sequences

Sequence LengthMass (Da)Tools
C4M1C3 [UniParc].

Last modified July 7, 2009. Version 1.
Checksum: 55ED2FE3B0836FF1

FASTA39243,247
        10         20         30         40         50         60 
MSNVLIFNVG SSSLTYKVFC SDNIVCSGKS NRVNVTGTEK PFIEHHLNGQ IIKIETPILN 

        70         80         90        100        110        120 
HPQAAKLIIQ FLKENHISIA FVGHRFVHGG SYFKKSAVID EVVLKELKEC LPLAPIHNPS 

       130        140        150        160        170        180 
SFGVIEISMK ELPTTRQYVA IDTAFHSTIS QAERTYAIPQ PYQSQYLKFG FHGLSYEYVI 

       190        200        210        220        230        240 
NSLKNVIDVS HSKIIACHLG TGGSSCCGIV NGKSFDTSMG NSTLAGLVMS TRCGDIDPTI 

       250        260        270        280        290        300 
PIDMIQQVGI EKVVDILNKK SGLLGVSELS SDMRDILHEI ETRGPKAKTC QLAFDVYIKQ 

       310        320        330        340        350        360 
LAKTIGGLMV EIGGLDLLVF TDQMGLEVWQ VRKAICDKMK FLGIELDDSL NEKSMGKKIE 

       370        380        390 
FLTMPSSKVQ VCVAPNDEEL VILQKGKELF QF 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DS571207 Genomic DNA. Translation: EAL50605.1.
RefSeqXP_655990.1. XM_650898.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4H0OX-ray2.40A/B1-392[»]
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING294381.C4M1C3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsrna_EHI_170010-1; rna_EHI_170010-1; EHI_170010.
GeneID3410291.
KEGGehi:EHI_170010.

Organism-specific databases

EuPathDBAmoebaDB:EHI_170010.

Phylogenomic databases

KOK00925.

Enzyme and pathway databases

UniPathwayUPA00340; UER00458.

Family and domain databases

HAMAPMF_00020. Acetate_kinase.
InterProIPR004372. Ac/Proprionate_kinase.
IPR000890. Aliphatic_acid_kin_short-chain.
[Graphical view]
PANTHERPTHR21060. PTHR21060. 1 hit.
PfamPF00871. Acetate_kinase. 1 hit.
[Graphical view]
PIRSFPIRSF000722. Acetate_prop_kin. 1 hit.
PRINTSPR00471. ACETATEKNASE.
TIGRFAMsTIGR00016. ackA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameC4M1C3_ENTHI
AccessionPrimary (citable) accession number: C4M1C3
Entry history
Integrated into UniProtKB/TrEMBL: July 7, 2009
Last sequence update: July 7, 2009
Last modified: July 9, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)