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C4LYV4

- C4LYV4_ENTHI

UniProt

C4LYV4 - C4LYV4_ENTHI

Protein
Submitted name:

Putative uncharacterized protein

Gene

EHI_010670

Organism
Entamoeba histolytica
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 29 (01 Oct 2014)
      Sequence version 1 (07 Jul 2009)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. Rho guanyl-nucleotide exchange factor activity Source: InterPro

    GO - Biological processi

    1. termination of G-protein coupled receptor signaling pathway Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Putative uncharacterized proteinImported
    Gene namesi
    ORF Names:EHI_010670Imported
    OrganismiEntamoeba histolyticaImported
    Taxonomic identifieri5759 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaArchamoebaeEntamoebidaeEntamoeba
    ProteomesiUP000001926: Partially assembled WGS sequence

    Organism-specific databases

    EuPathDBiAmoebaDB:EHI_010670.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-60101N.
    STRINGi294381.C4LYV4.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4GOUX-ray2.30A2-517[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Family and domain databases

    Gene3Di1.20.900.10. 1 hit.
    InterProiIPR000219. DH-domain.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    [Graphical view]
    PfamiPF00615. RGS. 1 hit.
    PF00621. RhoGEF. 1 hit.
    [Graphical view]
    SUPFAMiSSF48065. SSF48065. 1 hit.
    SSF48097. SSF48097. 1 hit.
    PROSITEiPS50010. DH_2. 1 hit.
    PS50132. RGS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C4LYV4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAATETAILE GWPTLQEVLE DSFMKRLLRC YLSDERSEEN LDFLESVGLY    50
    ESQFDKLTPK VRLEALNFIK DQFLDRNSER QVNLSYQIQQ SILKKLSEVT 100
    SNAPKDVFNE AKKATEYLLY TEQYTYFINK LNANTIGTGK KDVYSLYLNQ 150
    FPKTNPQPLY KPTLNKIIEI EKKSWNEDEV KRNTESIKSL VESLIQDECN 200
    YVGVLTSLSE FSEIMTKKQI LGPDVLKELF DHIPVLIQHH QKFISSLQEA 250
    KADEKVGEKL NSGLHFLVLY RYYLRHVPKN IAKLCSIGMT DEIEVGRELY 300
    PLPVIEEFDK QQKMTKKMSV LQMLVYPYFR VRTYQAYVDD FIKITKKDSQ 350
    EVKELEVVHS QLAIFQELIN TYSDINKIER ISDALKLLFP FSFTSIMPLF 400
    EGKNGICGIA SLDRFDKTDI NQLSMSLNSR KKLTLIILYR GVVVTDVPVI 450
    RKKGNVSNSI DKSFYSFTLI GDIRDFGTED STETIYIDVP EIKKRIWFGC 500
    ESTEEFKSCV EALRTILSN 519
    Length:519
    Mass (Da):60,137
    Last modified:July 7, 2009 - v1
    Checksum:i90DB6E8764F14109
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS571182 Genomic DNA. Translation: EAL47674.1.
    RefSeqiXP_653063.1. XM_647971.1.

    Genome annotation databases

    EnsemblProtistsirna_EHI_010670-1; rna_EHI_010670-1; EHI_010670.
    GeneIDi3407367.
    KEGGiehi:EHI_010670.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS571182 Genomic DNA. Translation: EAL47674.1 .
    RefSeqi XP_653063.1. XM_647971.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4GOU X-ray 2.30 A 2-517 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-60101N.
    STRINGi 294381.C4LYV4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi rna_EHI_010670-1 ; rna_EHI_010670-1 ; EHI_010670 .
    GeneIDi 3407367.
    KEGGi ehi:EHI_010670.

    Organism-specific databases

    EuPathDBi AmoebaDB:EHI_010670.

    Family and domain databases

    Gene3Di 1.20.900.10. 1 hit.
    InterProi IPR000219. DH-domain.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    [Graphical view ]
    Pfami PF00615. RGS. 1 hit.
    PF00621. RhoGEF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48065. SSF48065. 1 hit.
    SSF48097. SSF48097. 1 hit.
    PROSITEi PS50010. DH_2. 1 hit.
    PS50132. RGS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 30459 / HM-1:IMSSImported.
    2. Lorenzi H., Amedeo P., Inman J., Schobel S., Caler E.
      Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: ATCC 30459 / HM-1:IMSSImported.
    3. "Structural determinants of RGS-RhoGEF signaling critical to Entamoeba histolytica pathogenesis."
      Bosch D.E., Kimple A.J., Manning A.J., Muller R.E., Willard F.S., Machius M., Rogers S.L., Siderovski D.P.
      Structure 21:65-75(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 2-517.

    Entry informationi

    Entry nameiC4LYV4_ENTHI
    AccessioniPrimary (citable) accession number: C4LYV4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 7, 2009
    Last sequence update: July 7, 2009
    Last modified: October 1, 2014
    This is version 29 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3