C4LYV4 (C4LYV4_ENTHI) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Putative uncharacterized protein EMBL EAL47674.1

Gene names

ORF Names:

EHI_010670 EMBL EAL47674.1

Organism

Entamoeba histolytica [Reference proteome]

Taxonomic identifier

5759 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Amoebozoa › Archamoebae › Entamoebidae › Entamoeba

Protein attributes

Sequence length	519 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Technical term	3D-structure PDB 4GOU Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of Rho protein signal transduction Inferred from electronic annotation. Source: InterPro termination of G-protein coupled receptor signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular_component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular_function	Rho guanyl-nucleotide exchange factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	C4LYV4 [UniParc]. Last modified July 7, 2009. Version 1. Checksum: 90DB6E8764F14109	FASTA	519	60,137
	10 20 30 40 50 60 MAATETAILE GWPTLQEVLE DSFMKRLLRC YLSDERSEEN LDFLESVGLY ESQFDKLTPK 70 80 90 100 110 120 VRLEALNFIK DQFLDRNSER QVNLSYQIQQ SILKKLSEVT SNAPKDVFNE AKKATEYLLY 130 140 150 160 170 180 TEQYTYFINK LNANTIGTGK KDVYSLYLNQ FPKTNPQPLY KPTLNKIIEI EKKSWNEDEV 190 200 210 220 230 240 KRNTESIKSL VESLIQDECN YVGVLTSLSE FSEIMTKKQI LGPDVLKELF DHIPVLIQHH 250 260 270 280 290 300 QKFISSLQEA KADEKVGEKL NSGLHFLVLY RYYLRHVPKN IAKLCSIGMT DEIEVGRELY 310 320 330 340 350 360 PLPVIEEFDK QQKMTKKMSV LQMLVYPYFR VRTYQAYVDD FIKITKKDSQ EVKELEVVHS 370 380 390 400 410 420 QLAIFQELIN TYSDINKIER ISDALKLLFP FSFTSIMPLF EGKNGICGIA SLDRFDKTDI 430 440 450 460 470 480 NQLSMSLNSR KKLTLIILYR GVVVTDVPVI RKKGNVSNSI DKSFYSFTLI GDIRDFGTED 490 500 510 STETIYIDVP EIKKRIWFGC ESTEEFKSCV EALRTILSN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome of the protist parasite Entamoeba histolytica." Loftus B.J., Anderson I., Davies R., Alsmark U.C., Samuelson J., Amedeo P., Roncaglia P., Berriman M., Hirt R.P., Mann B.J., Nozaki T., Suh B., Pop M., Duchene M., Ackers J., Tannich E., Leippe M., Hofer M. , Bruchhaus I., Willhoeft U., Bhattacharya A., Chillingworth T., Churcher C.M., Hance Z., Harris B., Harris D., Jagels K., Moule S., Mungall K.L., Ormond D., Squares R., Whitehead S., Quail M.A., Rabbinowitsch E., Norbertczak H., Price C., Wang Z., Guillen N., Gilchrist C., Stroup S.E., Bhattacharya S., Lohia A., Foster P.G., Sicheritz-Ponten T., Weber C., Singh U., Mukherjee C., El-Sayed N.M.A., Petri W.A., Clark C.G., Embley T.M., Barrell B.G., Fraser C.M., Hall N. Nature 433:865-868(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 30459 / HM-1:IMSS.
[2]	Lorenzi H., Amedeo P., Inman J., Schobel S., Caler E. Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 30459 / HM-1:IMSS.
[3]	"Structural determinants of RGS-RhoGEF signaling critical to Entamoeba histolytica pathogenesis." Bosch D.E., Kimple A.J., Manning A.J., Muller R.E., Willard F.S., Machius M., Rogers S.L., Siderovski D.P. Structure 21:65-75(2013) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 2-517.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

DS571182 Genomic DNA. Translation: EAL47674.1.

RefSeq

XP_653063.1. XM_647971.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
4GOU	X-ray	2.30	A	2-517	[»]

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblProtists

rna_EHI_010670-1; rna_EHI_010670-1; EHI_010670.

GeneID

3407367.

KEGG

ehi:EHI_010670.

Organism-specific databases

EuPathDB

AmoebaDB:EHI_010670.

Phylogenomic databases

ProtClustDB

CLSZ2731413.

Family and domain databases

Gene3D

1.20.900.10. 1 hit.

InterPro

IPR000219. DH-domain.
IPR000342. Regulat_G_prot_signal.
IPR016137. Regulat_G_prot_signal_superfam.
[Graphical view]

Pfam

PF00615. RGS. 1 hit.
PF00621. RhoGEF. 1 hit.
[Graphical view]

SUPFAM

SSF48065. DH-domain. 1 hit.
SSF48097. Regulat_G_prot_signal_superfam. 1 hit.

PROSITE

PS50010. DH_2. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

C4LYV4_ENTHI

Accession

Primary (citable) accession number: C4LYV4

Entry history

Integrated into UniProtKB/TrEMBL:	July 7, 2009
Last sequence update:	July 7, 2009
Last modified:	May 1, 2013
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)