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C4LYV4

- C4LYV4_ENTHI

UniProt

C4LYV4 - C4LYV4_ENTHI

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Protein
Submitted name:

Putative uncharacterized protein

Gene

EHI_010670

Organism
Entamoeba histolytica
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. Rho guanyl-nucleotide exchange factor activity Source: InterPro

GO - Biological processi

  1. termination of G-protein coupled receptor signaling pathway Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized proteinImported
Gene namesi
ORF Names:EHI_010670Imported
OrganismiEntamoeba histolyticaImported
Taxonomic identifieri5759 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaArchamoebaeEntamoebidaeEntamoeba
ProteomesiUP000001926: Partially assembled WGS sequence

Organism-specific databases

EuPathDBiAmoebaDB:EHI_010670.

Interactioni

Protein-protein interaction databases

DIPiDIP-60101N.
STRINGi294381.C4LYV4.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4GOUX-ray2.30A2-517[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
InterProiIPR000219. DH-domain.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
[Graphical view]
PfamiPF00615. RGS. 1 hit.
PF00621. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF48097. SSF48097. 1 hit.
PROSITEiPS50010. DH_2. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C4LYV4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAATETAILE GWPTLQEVLE DSFMKRLLRC YLSDERSEEN LDFLESVGLY
60 70 80 90 100
ESQFDKLTPK VRLEALNFIK DQFLDRNSER QVNLSYQIQQ SILKKLSEVT
110 120 130 140 150
SNAPKDVFNE AKKATEYLLY TEQYTYFINK LNANTIGTGK KDVYSLYLNQ
160 170 180 190 200
FPKTNPQPLY KPTLNKIIEI EKKSWNEDEV KRNTESIKSL VESLIQDECN
210 220 230 240 250
YVGVLTSLSE FSEIMTKKQI LGPDVLKELF DHIPVLIQHH QKFISSLQEA
260 270 280 290 300
KADEKVGEKL NSGLHFLVLY RYYLRHVPKN IAKLCSIGMT DEIEVGRELY
310 320 330 340 350
PLPVIEEFDK QQKMTKKMSV LQMLVYPYFR VRTYQAYVDD FIKITKKDSQ
360 370 380 390 400
EVKELEVVHS QLAIFQELIN TYSDINKIER ISDALKLLFP FSFTSIMPLF
410 420 430 440 450
EGKNGICGIA SLDRFDKTDI NQLSMSLNSR KKLTLIILYR GVVVTDVPVI
460 470 480 490 500
RKKGNVSNSI DKSFYSFTLI GDIRDFGTED STETIYIDVP EIKKRIWFGC
510
ESTEEFKSCV EALRTILSN
Length:519
Mass (Da):60,137
Last modified:July 7, 2009 - v1
Checksum:i90DB6E8764F14109
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS571182 Genomic DNA. Translation: EAL47674.1.
RefSeqiXP_653063.1. XM_647971.1.

Genome annotation databases

EnsemblProtistsirna_EHI_010670-1; rna_EHI_010670-1; EHI_010670.
GeneIDi3407367.
KEGGiehi:EHI_010670.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS571182 Genomic DNA. Translation: EAL47674.1 .
RefSeqi XP_653063.1. XM_647971.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4GOU X-ray 2.30 A 2-517 [» ]
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-60101N.
STRINGi 294381.C4LYV4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi rna_EHI_010670-1 ; rna_EHI_010670-1 ; EHI_010670 .
GeneIDi 3407367.
KEGGi ehi:EHI_010670.

Organism-specific databases

EuPathDBi AmoebaDB:EHI_010670.

Family and domain databases

Gene3Di 1.20.900.10. 1 hit.
InterProi IPR000219. DH-domain.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
[Graphical view ]
Pfami PF00615. RGS. 1 hit.
PF00621. RhoGEF. 1 hit.
[Graphical view ]
SUPFAMi SSF48065. SSF48065. 1 hit.
SSF48097. SSF48097. 1 hit.
PROSITEi PS50010. DH_2. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 30459 / HM-1:IMSSImported.
  2. Lorenzi H., Amedeo P., Inman J., Schobel S., Caler E.
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: ATCC 30459 / HM-1:IMSSImported.
  3. "Structural determinants of RGS-RhoGEF signaling critical to Entamoeba histolytica pathogenesis."
    Bosch D.E., Kimple A.J., Manning A.J., Muller R.E., Willard F.S., Machius M., Rogers S.L., Siderovski D.P.
    Structure 21:65-75(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 2-517.

Entry informationi

Entry nameiC4LYV4_ENTHI
AccessioniPrimary (citable) accession number: C4LYV4
Entry historyi
Integrated into UniProtKB/TrEMBL: July 7, 2009
Last sequence update: July 7, 2009
Last modified: October 1, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteomeImported

External Data

Dasty 3