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C4LJE7 (C4LJE7_CORK4) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddlA EMBL ACR17952.1
Synonyms:ddl HAMAP-Rule MF_00047
Ordered Locus Names:ckrop_1208 EMBL ACR17952.1
OrganismCorynebacterium kroppenstedtii (strain DSM 44385 / CCUG 35717) [Complete proteome] [HAMAP] EMBL ACR17952.1
Taxonomic identifier645127 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium

Protein attributes

Sequence length412 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS011095

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS011095

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS011095.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS011095

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain199 – 403205ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding226 – 28156ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding3581Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3701Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3701Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding3721Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
C4LJE7 [UniParc].

Last modified July 7, 2009. Version 1.
Checksum: DE3FA1DA38DD33E5

FASTA41244,106
        10         20         30         40         50         60 
MPLHLVPVTT SEPSSASSAD ITSQSASPLV ASTQSGPGAG GERDENSGHN EHSRIRVAVV 

        70         80         90        100        110        120 
YGGRSSEHSI SCVSAGAVIS HLDPDRYQVV PIGITRDGRW VVGSSDPKEL SIRERQLPEV 

       130        140        150        160        170        180 
KAGTSLSLSL DPQHAGRFVY ADGPDVGQVF ADVDVIFPVL HGGFGEDGTV QGLFDMASVP 

       190        200        210        220        230        240 
YVGAGVLASA ASMDKEFTKK LAAAEGLPIG RDVVLRETRS LTEEEKNLLG LPVFVKPARG 

       250        260        270        280        290        300 
GSSIGISKVD QWDELDDALD LARQHDSKVI VESMIVGTEV ECGVLQRPDG TVEASLPAQL 

       310        320        330        340        350        360 
EDTESGDEGF YGFDTKYLDN VITAQIPPHF DDDTIRHIRE LAVETFHALD CEGLARIDFF 

       370        380        390        400        410 
VTDRGPVLNE INTMPGFTPI SMYPQMFGAM GIDYPDLLDL LIQRAMVAHP GA 

« Hide

References

[1]"Ultrafast pyrosequencing of Corynebacterium kroppenstedtii DSM44385 revealed insights into the physiology of a lipophilic corynebacterium that lacks mycolic acids."
Tauch A., Schneider J., Szczepanowski R., Tilker A., Viehoever P., Gartemann K.H., Arnold W., Blom J., Brinkrolf K., Brune I., Gotker S., Weisshaar B., Goesmann A., Droge M., Puhler A.
J. Biotechnol. 136:22-30(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 44385 / CCUG 35717.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001620 Genomic DNA. Translation: ACR17952.1.
RefSeqYP_002906495.1. NC_012704.1.

3D structure databases

ProteinModelPortalC4LJE7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING645127.ckrop_1208.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACR17952; ACR17952; ckrop_1208.
GeneID7876550.
KEGGckp:ckrop_1208.
PATRIC21517757. VBICorKro120627_1243.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000011593.
KOK01921.
OMAIECGVLG.
OrthoDBEOG64BQ73.

Enzyme and pathway databases

BioCycCKRO645127:GI7D-1196-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC4LJE7_CORK4
AccessionPrimary (citable) accession number: C4LJE7
Entry history
Integrated into UniProtKB/TrEMBL: July 7, 2009
Last sequence update: July 7, 2009
Last modified: June 11, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)