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C4LJE7

- C4LJE7_CORK4

UniProt

C4LJE7 - C4LJE7_CORK4

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Protein
D-alanine--D-alanine ligase
Gene
ddlA, ddl, ckrop_1208
Organism
Corynebacterium kroppenstedtii (strain DSM 44385 / CCUG 35717)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cell wall formation By similarity.UniRule annotationSAAS annotations

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotationSAAS annotations

Cofactori

Binds 2 magnesium or manganese ions per subunit By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi358 – 3581Magnesium or manganese 1 By similarityUniRule annotation
Metal bindingi370 – 3701Magnesium or manganese 1 By similarityUniRule annotation
Metal bindingi370 – 3701Magnesium or manganese 2 By similarityUniRule annotation
Metal bindingi372 – 3721Magnesium or manganese 2 By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi226 – 28156ATP By similarityUniRule annotation
Add
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. D-alanine-D-alanine ligase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. manganese ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
  2. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationSAAS annotationsImported

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotations, Peptidoglycan synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, MagnesiumUniRule annotationSAAS annotations, ManganeseUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding

Enzyme and pathway databases

BioCyciCKRO645127:GI7D-1196-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotation (EC:6.3.2.4UniRule annotation)
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene namesi
Name:ddlAImported
Synonyms:ddlUniRule annotation
Ordered Locus Names:ckrop_1208Imported
OrganismiCorynebacterium kroppenstedtii (strain DSM 44385 / CCUG 35717)Imported
Taxonomic identifieri645127 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000001473: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Protein-protein interaction databases

STRINGi645127.ckrop_1208.

Structurei

3D structure databases

ProteinModelPortaliC4LJE7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini199 – 403205ATP-grasp By similarityUniRule annotation
Add
BLAST

Sequence similaritiesi

Contains 1 ATP-grasp domain.UniRule annotation
Contains ATP-grasp domain.SAAS annotations

Phylogenomic databases

eggNOGiCOG1181.
HOGENOMiHOG000011593.
KOiK01921.
OMAiIECGVLG.
OrthoDBiEOG64BQ73.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPiMF_00047. Dala_Dala_lig.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERiPTHR23132. PTHR23132. 1 hit.
PfamiPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C4LJE7-1 [UniParc]FASTAAdd to Basket

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MPLHLVPVTT SEPSSASSAD ITSQSASPLV ASTQSGPGAG GERDENSGHN    50
EHSRIRVAVV YGGRSSEHSI SCVSAGAVIS HLDPDRYQVV PIGITRDGRW 100
VVGSSDPKEL SIRERQLPEV KAGTSLSLSL DPQHAGRFVY ADGPDVGQVF 150
ADVDVIFPVL HGGFGEDGTV QGLFDMASVP YVGAGVLASA ASMDKEFTKK 200
LAAAEGLPIG RDVVLRETRS LTEEEKNLLG LPVFVKPARG GSSIGISKVD 250
QWDELDDALD LARQHDSKVI VESMIVGTEV ECGVLQRPDG TVEASLPAQL 300
EDTESGDEGF YGFDTKYLDN VITAQIPPHF DDDTIRHIRE LAVETFHALD 350
CEGLARIDFF VTDRGPVLNE INTMPGFTPI SMYPQMFGAM GIDYPDLLDL 400
LIQRAMVAHP GA 412
Length:412
Mass (Da):44,106
Last modified:July 7, 2009 - v1
Checksum:iDE3FA1DA38DD33E5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001620 Genomic DNA. Translation: ACR17952.1.
RefSeqiWP_012731839.1. NC_012704.1.
YP_002906495.1. NC_012704.1.

Genome annotation databases

EnsemblBacteriaiACR17952; ACR17952; ckrop_1208.
GeneIDi7876550.
KEGGickp:ckrop_1208.
PATRICi21517757. VBICorKro120627_1243.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001620 Genomic DNA. Translation: ACR17952.1 .
RefSeqi WP_012731839.1. NC_012704.1.
YP_002906495.1. NC_012704.1.

3D structure databases

ProteinModelPortali C4LJE7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 645127.ckrop_1208.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACR17952 ; ACR17952 ; ckrop_1208 .
GeneIDi 7876550.
KEGGi ckp:ckrop_1208.
PATRICi 21517757. VBICorKro120627_1243.

Phylogenomic databases

eggNOGi COG1181.
HOGENOMi HOG000011593.
KOi K01921.
OMAi IECGVLG.
OrthoDBi EOG64BQ73.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci CKRO645127:GI7D-1196-MONOMER.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPi MF_00047. Dala_Dala_lig.
InterProi IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view ]
PANTHERi PTHR23132. PTHR23132. 1 hit.
Pfami PF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view ]
SUPFAMi SSF52440. SSF52440. 1 hit.
TIGRFAMsi TIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Ultrafast pyrosequencing of Corynebacterium kroppenstedtii DSM44385 revealed insights into the physiology of a lipophilic corynebacterium that lacks mycolic acids."
    Tauch A., Schneider J., Szczepanowski R., Tilker A., Viehoever P., Gartemann K.H., Arnold W., Blom J., Brinkrolf K., Brune I., Gotker S., Weisshaar B., Goesmann A., Droge M., Puhler A.
    J. Biotechnol. 136:22-30(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 44385 / CCUG 35717.

Entry informationi

Entry nameiC4LJE7_CORK4
AccessioniPrimary (citable) accession number: C4LJE7
Entry historyi
Integrated into UniProtKB/TrEMBL: July 7, 2009
Last sequence update: July 7, 2009
Last modified: September 3, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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