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Protein

Adenine phosphoribosyltransferase

Gene

apt

Organism
Corynebacterium kroppenstedtii (strain DSM 44385 / CCUG 35717)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.UniRule annotation

Catalytic activityi

AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Pathwayi: AMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes AMP from adenine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Adenine phosphoribosyltransferase (apt)
This subpathway is part of the pathway AMP biosynthesis via salvage pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes AMP from adenine, the pathway AMP biosynthesis via salvage pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Purine salvage

Enzyme and pathway databases

BioCyciCKRO645127:GI7D-1014-MONOMER.
UniPathwayiUPA00588; UER00646.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenine phosphoribosyltransferaseUniRule annotation (EC:2.4.2.7UniRule annotation)
Short name:
APRTUniRule annotation
Gene namesi
Name:aptUniRule annotation
Ordered Locus Names:ckrop_1024
OrganismiCorynebacterium kroppenstedtii (strain DSM 44385 / CCUG 35717)
Taxonomic identifieri645127 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000001473 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 183183Adenine phosphoribosyltransferasePRO_1000201658Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi645127.ckrop_1024.

Structurei

3D structure databases

ProteinModelPortaliC4LIX2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the purine/pyrimidine phosphoribosyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4109003. Bacteria.
COG0503. LUCA.
HOGENOMiHOG000036776.
KOiK00759.
OMAiATVEIHA.
OrthoDBiEOG6T4S55.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_00004. Aden_phosphoribosyltr.
InterProiIPR005764. Ade_phspho_trans.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
PROSITEiPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C4LIX2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDSEYSSAA DAVANLVRRV PGFPSEGVVF EDLTPVLADA GAFRLIVDEL
60 70 80 90 100
AEAARSYHAD IIGGLDARGF LLGSAVAYQL GLGILAVRKE GKLPPPVFHR
110 120 130 140 150
GYDLEYGHAA LEIPREGLNI QGKNIVLIDD VLATGGTLCA SRALLEEAGA
160 170 180
NVAGLAVILE VEALEGRKRL ADLPLTVVGE RSE
Length:183
Mass (Da):19,261
Last modified:July 7, 2009 - v1
Checksum:i1A65C4FCB51DACA2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001620 Genomic DNA. Translation: ACR17777.1.
RefSeqiWP_012731664.1. NC_012704.1.

Genome annotation databases

EnsemblBacteriaiACR17777; ACR17777; ckrop_1024.
KEGGickp:ckrop_1024.
PATRICi21517375. VBICorKro120627_1057.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001620 Genomic DNA. Translation: ACR17777.1.
RefSeqiWP_012731664.1. NC_012704.1.

3D structure databases

ProteinModelPortaliC4LIX2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi645127.ckrop_1024.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACR17777; ACR17777; ckrop_1024.
KEGGickp:ckrop_1024.
PATRICi21517375. VBICorKro120627_1057.

Phylogenomic databases

eggNOGiENOG4109003. Bacteria.
COG0503. LUCA.
HOGENOMiHOG000036776.
KOiK00759.
OMAiATVEIHA.
OrthoDBiEOG6T4S55.

Enzyme and pathway databases

UniPathwayiUPA00588; UER00646.
BioCyciCKRO645127:GI7D-1014-MONOMER.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_00004. Aden_phosphoribosyltr.
InterProiIPR005764. Ade_phspho_trans.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
PROSITEiPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Ultrafast pyrosequencing of Corynebacterium kroppenstedtii DSM44385 revealed insights into the physiology of a lipophilic corynebacterium that lacks mycolic acids."
    Tauch A., Schneider J., Szczepanowski R., Tilker A., Viehoever P., Gartemann K.-H., Arnold W., Blom J., Brinkrolf K., Brune I., Goetker S., Weisshaar B., Goesmann A., Droege M., Puehler A.
    J. Biotechnol. 136:22-30(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 44385 / CCUG 35717.

Entry informationi

Entry nameiAPT_CORK4
AccessioniPrimary (citable) accession number: C4LIX2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 7, 2009
Last modified: November 11, 2015
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.