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Protein

L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase

Gene

mshC

Organism
Corynebacterium kroppenstedtii (strain DSM 44385 / JCM 11950 / CIP 105744 / CCUG 35717)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins.UniRule annotation

Catalytic activityi

1-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + L-cysteine + ATP = 1-O-(2-(L-cysteinamido)-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + AMP + diphosphate.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi48ZincUniRule annotation1
Binding sitei63Cysteinyl adenylateUniRule annotation1
Binding sitei232Cysteinyl adenylateUniRule annotation1
Metal bindingi236ZincUniRule annotation1
Metal bindingi261ZincUniRule annotation1
Binding sitei288Cysteinyl adenylate; via amide nitrogen and carbonyl oxygenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligaseUniRule annotation (EC:6.3.1.13UniRule annotation)
Short name:
L-Cys:GlcN-Ins ligaseUniRule annotation
Alternative name(s):
Mycothiol ligaseUniRule annotation
Short name:
MSH ligaseUniRule annotation
Gene namesi
Name:mshCUniRule annotation
Ordered Locus Names:ckrop_0920
OrganismiCorynebacterium kroppenstedtii (strain DSM 44385 / JCM 11950 / CIP 105744 / CCUG 35717)
Taxonomic identifieri645127 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000001473 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004004411 – 520L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligaseAdd BLAST520

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi645127.ckrop_0920

Structurei

3D structure databases

ProteinModelPortaliC4LIL9
SMRiC4LIL9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni48 – 51Cysteinyl adenylate bindingUniRule annotation4
Regioni86 – 88Cysteinyl adenylate bindingUniRule annotation3
Regioni254 – 256Cysteinyl adenylate bindingUniRule annotation3

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi50 – 60"HIGH" regionUniRule annotationAdd BLAST11
Motifi192 – 197"ERGGDP" regionUniRule annotation6
Motifi294 – 298"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8N Bacteria
COG0215 LUCA
HOGENOMiHOG000245251
KOiK15526
OMAiKVERMAG
OrthoDBiPOG091H004K

Family and domain databases

CDDicd00672 CysRS_core, 1 hit
Gene3Di3.40.50.620, 1 hit
HAMAPiMF_01697 MshC, 1 hit
InterProiView protein in InterPro
IPR024909 Cys-tRNA/MSH_ligase
IPR017812 Mycothiol_ligase_MshC
IPR014729 Rossmann-like_a/b/a_fold
IPR032678 tRNA-synt_1_cat_dom
PANTHERiPTHR10890 PTHR10890, 2 hits
PTHR10890:SF13 PTHR10890:SF13, 2 hits
PfamiView protein in Pfam
PF01406 tRNA-synt_1e, 1 hit
PRINTSiPR00983 TRNASYNTHCYS
TIGRFAMsiTIGR03447 mycothiol_MshC, 1 hit

Sequencei

Sequence statusi: Complete.

C4LIL9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSWQKPLVA DFRSVVGEDQ PVPLHMWDTA SREVTPLTPS DEATVYVCGI
60 70 80 90 100
TPYDSTHLGH AATYVTFDVL NRQLLANGHR VNFVQNVTDV DDPLFERAQR
110 120 130 140 150
DGVDWQELGE EQTDLFRQDM ANLGVIPPTS YIGAVEAIPD VIDMVSTLLD
160 170 180 190 200
NGSAYVVDDP TYPDVYADRT ATPQFGYESR YDEATMEQFF AERGGDPDRP
210 220 230 240 250
GKRDPLDSLL WRAERPGEPA WDSPFGRGRP GWHIECAAIA ARYLGSHFDV
260 270 280 290 300
QGGGEDLIFP HHEYSAAHVE AACGVERMAD HYMHTGLIAL GGVKMSKSLG
310 320 330 340 350
NLVFVSRLCN AGTDPSSIRL ALYAGHYRDQ RNWSDALLAA ASRRLALWRT
360 370 380 390 400
AVETVHAHND ADSEARARRL VDDVRQALAT DLDTPAAVDL VDEWAGSIVD
410 420 430 440 450
KEKIWDLPGV DGKNAHESLS VPVPCAAPAT DDKLSVAQGK ITILDDGKDS
460 470 480 490 500
EADAKSVELA SATAGTQRCG AHSHASGELT VDLLPAPHQR GDAPSALYSH
510 520
LSPAAALVAG CVDALLGLKL
Length:520
Mass (Da):56,394
Last modified:July 7, 2009 - v1
Checksum:iF59AF8023549161E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001620 Genomic DNA Translation: ACR17674.1

Genome annotation databases

EnsemblBacteriaiACR17674; ACR17674; ckrop_0920
KEGGickp:ckrop_0920

Similar proteinsi

Entry informationi

Entry nameiMSHC_CORK4
AccessioniPrimary (citable) accession number: C4LIL9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: July 7, 2009
Last modified: March 28, 2018
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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