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Protein

Glucose-1-phosphate adenylyltransferase

Gene

glgC

Organism
Corynebacterium kroppenstedtii (strain DSM 44385 / JCM 11950 / CIP 105744 / CCUG 35717)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.UniRule annotation

Catalytic activityi

ATP + alpha-D-glucose 1-phosphate = diphosphate + ADP-glucose.UniRule annotation

Pathwayi: glycogen biosynthesis

This protein is involved in the pathway glycogen biosynthesis, which is part of Glycan biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway glycogen biosynthesis and in Glycan biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei164Alpha-D-glucose 1-phosphate; via amide nitrogenUniRule annotation1
Binding sitei197Alpha-D-glucose 1-phosphate; via carbonyl oxygenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processCarbohydrate metabolism, Glycogen biosynthesis, Glycogen metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00164

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-1-phosphate adenylyltransferaseUniRule annotation (EC:2.7.7.27UniRule annotation)
Alternative name(s):
ADP-glucose pyrophosphorylaseUniRule annotation
Short name:
ADPGlc PPaseUniRule annotation
ADP-glucose synthaseUniRule annotation
Gene namesi
Name:glgCUniRule annotation
Ordered Locus Names:ckrop_0641
OrganismiCorynebacterium kroppenstedtii (strain DSM 44385 / JCM 11950 / CIP 105744 / CCUG 35717)
Taxonomic identifieri645127 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000001473 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002122971 – 411Glucose-1-phosphate adenylyltransferaseAdd BLAST411

Proteomic databases

PRIDEiC4LHU9

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi645127.ckrop_0641

Structurei

3D structure databases

ProteinModelPortaliC4LHU9
SMRiC4LHU9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni179 – 180Alpha-D-glucose 1-phosphate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QQ4 Bacteria
COG0448 LUCA
HOGENOMiHOG000278607
KOiK00975
OMAiHCVLGVR
OrthoDBiPOG091H09L2

Family and domain databases

Gene3Di3.90.550.10, 1 hit
HAMAPiMF_00624 GlgC, 1 hit
InterProiView protein in InterPro
IPR011831 ADP-Glc_PPase
IPR005836 ADP_Glu_pyroP_CS
IPR023049 GlgC_bac
IPR005835 NTP_transferase_dom
IPR029044 Nucleotide-diphossugar_trans
IPR011004 Trimer_LpxA-like_sf
PfamiView protein in Pfam
PF00483 NTP_transferase, 1 hit
SUPFAMiSSF51161 SSF51161, 1 hit
SSF53448 SSF53448, 2 hits
TIGRFAMsiTIGR02091 glgC, 1 hit
PROSITEiView protein in PROSITE
PS00809 ADP_GLC_PYROPHOSPH_2, 1 hit
PS00810 ADP_GLC_PYROPHOSPH_3, 1 hit

Sequencei

Sequence statusi: Complete.

C4LHU9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSQPHVLSI VLAGGEGKRL FPFTADRAKP AVPFGGSYRL IDFVLSNLVN
60 70 80 90 100
AGYMKVCVLT QYKSHSLDRH ISQSWQLSGL AGEYITPVPA QQRLGKRWFT
110 120 130 140 150
GSADAILQSL NLIYDEDPEY IIVFGADHVY RMDPEQMVKE HIESGAACSV
160 170 180 190 200
AGIRVPRKEA TAFGCIQADD DGTITEFLEK PADPPATPDD PDVTFASMGN
210 220 230 240 250
YVFTTQALID ALKEDSEDEN SAHDMGGNII PYFVNRGEAH VHDFSRNVVP
260 270 280 290 300
GETDRDHGYW RDVGTVDAFY EAHMDLISVY PVFNLYNRKW PIHTSDDSNL
310 320 330 340 350
PPAKFVKGGI AQSSIVAAGC IISAGTVRNS VLGPGVVVEE GASVEGCVLM
360 370 380 390 400
DGVRIGKGAV VRHAILDKNV RVGDNALIGV DRARDSERFT LSQGGVVCVP
410
KNYELHGADE D
Length:411
Mass (Da):44,769
Last modified:July 7, 2009 - v1
Checksum:i123E176409C5F5A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001620 Genomic DNA Translation: ACR17404.1
RefSeqiWP_012731291.1, NC_012704.1

Genome annotation databases

EnsemblBacteriaiACR17404; ACR17404; ckrop_0641
KEGGickp:ckrop_0641

Similar proteinsi

Entry informationi

Entry nameiGLGC_CORK4
AccessioniPrimary (citable) accession number: C4LHU9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 7, 2009
Last modified: May 23, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health