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Protein

1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase

Gene

mshB

Organism
Corynebacterium kroppenstedtii (strain DSM 44385 / JCM 11950 / CIP 105744 / CCUG 35717)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the deacetylation of 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway.UniRule annotation

Catalytic activityi

1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + H2O = 1-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + acetate.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi6 – 61ZincUniRule annotation
Metal bindingi9 – 91ZincUniRule annotation
Metal bindingi144 – 1441ZincUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciCKRO645127:GI7D-617-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylaseUniRule annotation (EC:3.5.1.103UniRule annotation)
Short name:
GlcNAc-Ins deacetylaseUniRule annotation
Alternative name(s):
N-acetyl-1-D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase
Gene namesi
Name:mshBUniRule annotation
Ordered Locus Names:ckrop_0626
OrganismiCorynebacterium kroppenstedtii (strain DSM 44385 / JCM 11950 / CIP 105744 / CCUG 35717)
Taxonomic identifieri645127 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000001473 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3883881D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylasePRO_0000400181Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi645127.ckrop_0626.

Structurei

3D structure databases

ProteinModelPortaliC4LHT4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MshB deacetylase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2120. LUCA.
HOGENOMiHOG000241173.
KOiK15525.
OMAiHATQLWV.
OrthoDBiEOG6NSGK1.

Family and domain databases

Gene3Di3.40.50.10320. 2 hits.
HAMAPiMF_01696. MshB.
InterProiIPR003737. GlcNAc_PI_deacetylase-related.
IPR024078. LmbE-like_dom.
IPR017810. Mycothiol_biosynthesis_MshB.
[Graphical view]
PANTHERiPTHR12993. PTHR12993. 2 hits.
PfamiPF02585. PIG-L. 1 hit.
[Graphical view]
SUPFAMiSSF102588. SSF102588. 1 hit.

Sequencei

Sequence statusi: Complete.

C4LHT4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVHAHPDDE ALWTGGLLAH LSRRGADVRV VTCTLGEQGE VIGEPMQGLI
60 70 80 90 100
ADEADMLGGF RYRELEDSLR ILGVNGVHHR PCVLGGVGCW RDSGMVGTPS
110 120 130 140 150
ADHPRAFVKS GQQAVDALKA LMSEFCPDIV VTYGPDGGYG HPDHIRAHEI
160 170 180 190 200
THAAVAELPH TSAPELGGDN TDLFSAVLAR RHGGRETSAD HGIPDPVVLW
210 220 230 240 250
AVRGETALKQ AGRAISRIPD GWVAPSGMDF SFVDGAAGAV DSASSEKTPD
260 270 280 290 300
KITEPDLAFV PDDLVDLAVQ LSDADIEAQA NAMAAHATQL WIADGRQSWT
310 320 330 340 350
NPESAWAVSD PTVAPKVFAL SNRIAQPLMR EEHYVVAYGG SGPWAKTTPA
360 370 380
RYAYDSSVVR ARGRSAFSLD QADEGAAHDT SEQSGQRR
Length:388
Mass (Da):41,274
Last modified:July 7, 2009 - v1
Checksum:iB1D8AE4D96F9A215
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001620 Genomic DNA. Translation: ACR17389.1.

Genome annotation databases

EnsemblBacteriaiACR17389; ACR17389; ckrop_0626.
KEGGickp:ckrop_0626.
PATRICi21516543. VBICorKro120627_0650.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001620 Genomic DNA. Translation: ACR17389.1.

3D structure databases

ProteinModelPortaliC4LHT4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi645127.ckrop_0626.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACR17389; ACR17389; ckrop_0626.
KEGGickp:ckrop_0626.
PATRICi21516543. VBICorKro120627_0650.

Phylogenomic databases

eggNOGiCOG2120. LUCA.
HOGENOMiHOG000241173.
KOiK15525.
OMAiHATQLWV.
OrthoDBiEOG6NSGK1.

Enzyme and pathway databases

BioCyciCKRO645127:GI7D-617-MONOMER.

Family and domain databases

Gene3Di3.40.50.10320. 2 hits.
HAMAPiMF_01696. MshB.
InterProiIPR003737. GlcNAc_PI_deacetylase-related.
IPR024078. LmbE-like_dom.
IPR017810. Mycothiol_biosynthesis_MshB.
[Graphical view]
PANTHERiPTHR12993. PTHR12993. 2 hits.
PfamiPF02585. PIG-L. 1 hit.
[Graphical view]
SUPFAMiSSF102588. SSF102588. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Ultrafast pyrosequencing of Corynebacterium kroppenstedtii DSM44385 revealed insights into the physiology of a lipophilic corynebacterium that lacks mycolic acids."
    Tauch A., Schneider J., Szczepanowski R., Tilker A., Viehoever P., Gartemann K.-H., Arnold W., Blom J., Brinkrolf K., Brune I., Goetker S., Weisshaar B., Goesmann A., Droege M., Puehler A.
    J. Biotechnol. 136:22-30(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 44385 / JCM 11950 / CIP 105744 / CCUG 35717.

Entry informationi

Entry nameiMSHB_CORK4
AccessioniPrimary (citable) accession number: C4LHT4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: July 7, 2009
Last modified: July 6, 2016
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.