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Protein

Mycothiol acetyltransferase

Gene

mshD

Organism
Corynebacterium kroppenstedtii (strain DSM 44385 / JCM 11950 / CIP 105744 / CCUG 35717)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.UniRule annotation

Catalytic activityi

Desacetylmycothiol + acetyl-CoA = CoA + mycothiol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei59Desacetylmycothiol; via amide nitrogenUniRule annotation1
Binding sitei229DesacetylmycothiolUniRule annotation1
Binding sitei280DesacetylmycothiolUniRule annotation1
Binding sitei295DesacetylmycothiolUniRule annotation1
Binding sitei333Desacetylmycothiol; via carbonyl oxygenUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionAcyltransferase, Transferase

Enzyme and pathway databases

BioCyciCKRO645127:G1GEV-386-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Mycothiol acetyltransferaseUniRule annotation (EC:2.3.1.189UniRule annotation)
Short name:
MSH acetyltransferaseUniRule annotation
Alternative name(s):
Mycothiol synthaseUniRule annotation
Gene namesi
Name:mshDUniRule annotation
Ordered Locus Names:ckrop_0397
OrganismiCorynebacterium kroppenstedtii (strain DSM 44385 / JCM 11950 / CIP 105744 / CCUG 35717)
Taxonomic identifieri645127 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000001473 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004002531 – 361Mycothiol acetyltransferaseAdd BLAST361

Proteomic databases

PRIDEiC4LH71

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi645127.ckrop_0397

Structurei

3D structure databases

ProteinModelPortaliC4LH71
SMRiC4LH71
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 173N-acetyltransferase 1UniRule annotationAdd BLAST149
Domaini195 – 361N-acetyltransferase 2UniRule annotationAdd BLAST167

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni98 – 100Acetyl-CoA binding 1UniRule annotation3
Regioni299 – 301Acetyl-CoA binding 2UniRule annotation3
Regioni306 – 312Acetyl-CoA binding 2UniRule annotation7
Regioni338 – 343Acetyl-CoA binding 2UniRule annotation6

Sequence similaritiesi

Belongs to the acetyltransferase family. MshD subfamily.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4108RTV Bacteria
COG0456 LUCA
HOGENOMiHOG000248937
KOiK15520
OMAiAEPWFDP
OrthoDBiPOG091H09IL

Family and domain databases

HAMAPiMF_01698 MshD, 1 hit
InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR000182 GNAT_dom
IPR017813 Mycothiol_AcTrfase
PfamiView protein in Pfam
PF00583 Acetyltransf_1, 1 hit
PIRSFiPIRSF021524 MSH_acetyltransferase, 1 hit
SUPFAMiSSF55729 SSF55729, 2 hits
TIGRFAMsiTIGR03448 mycothiol_MshD, 1 hit
PROSITEiView protein in PROSITE
PS51186 GNAT, 2 hits

Sequencei

Sequence statusi: Complete.

C4LH71-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADAPTFNAQ PCDIITQLVL GPVSPRVRNA RQASADRWME IETILHESTR
60 70 80 90 100
HDGVAPFSEQ FLRGMEEPDL NHWHALVRVD GHVRGIAAVD PSGPAVELAV
110 120 130 140 150
HPSYRRGGLA TALQRAVRAH ASSLGLGDER DIHTNGIGLT WWAHGDLPPA
160 170 180 190 200
RAAAEHIGAT ADRELLVMEL PGSVVKDESD NNPVAQAAAT LPDDVTVLSW
210 220 230 240 250
TESARRWGKD AVDAAWLAVN NEAFDWHPEQ GGWDQARLDQ ARRASWYDPD
260 270 280 290 300
GVLLLWGSEG DQKDGDTDSL PPLLGFHWTK LAREGDDETG RKVGEVYVIG
310 320 330 340 350
LARKAQGRGL GRASTAKGIQ YLASNDAAYV ELYVEADNAP AVHAYEALGF
360
TVVERHTAWK F
Length:361
Mass (Da):39,370
Last modified:July 7, 2009 - v1
Checksum:i26B69FDF3F78A99F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001620 Genomic DNA Translation: ACR17176.1
RefSeqiWP_012731064.1, NC_012704.1

Genome annotation databases

EnsemblBacteriaiACR17176; ACR17176; ckrop_0397
KEGGickp:ckrop_0397

Similar proteinsi

Entry informationi

Entry nameiMSHD_CORK4
AccessioniPrimary (citable) accession number: C4LH71
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: July 7, 2009
Last modified: May 23, 2018
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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