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Protein

Peptide methionine sulfoxide reductase MsrA

Gene

msrA

Organism
Corynebacterium kroppenstedtii (strain DSM 44385 / JCM 11950 / CIP 105744 / CCUG 35717)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.UniRule annotation

Catalytic activityi

Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin.UniRule annotation
L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei59UniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase

Enzyme and pathway databases

BioCyciCKRO645127:G1GEV-113-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide methionine sulfoxide reductase MsrAUniRule annotation (EC:1.8.4.11UniRule annotation)
Short name:
Protein-methionine-S-oxide reductaseUniRule annotation
Alternative name(s):
Peptide-methionine (S)-S-oxide reductaseUniRule annotation
Short name:
Peptide Met(O) reductaseUniRule annotation
Gene namesi
Name:msrAUniRule annotation
Ordered Locus Names:ckrop_0108
OrganismiCorynebacterium kroppenstedtii (strain DSM 44385 / JCM 11950 / CIP 105744 / CCUG 35717)
Taxonomic identifieri645127 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000001473 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002151861 – 220Peptide methionine sulfoxide reductase MsrAAdd BLAST220

Proteomic databases

PRIDEiC4LG69

Interactioni

Protein-protein interaction databases

STRINGi645127.ckrop_0108

Structurei

3D structure databases

ProteinModelPortaliC4LG69
SMRiC4LG69
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MsrA Met sulfoxide reductase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108HW8 Bacteria
COG0225 LUCA
HOGENOMiHOG000263862
KOiK07304
OMAiMRQGGDI
OrthoDBiPOG091H059H

Family and domain databases

Gene3Di3.30.1060.10, 1 hit
HAMAPiMF_01401 MsrA, 1 hit
InterProiView protein in InterPro
IPR002569 Met_Sox_Rdtase_MsrA
IPR036509 Met_Sox_Rdtase_MsrA_sf
PfamiView protein in Pfam
PF01625 PMSR, 1 hit
SUPFAMiSSF55068 SSF55068, 1 hit
TIGRFAMsiTIGR00401 msrA, 1 hit

Sequencei

Sequence statusi: Complete.

C4LG69-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFLFGTRPT PTSIVNREDA LPGRDEPILP HPAPHTVLGT PIDGPWKDGQ
60 70 80 90 100
RSVVVGLGCF WGAEKLFWQI DGVESTAVGY AGGYTPNPTY REVCTGRTGH
110 120 130 140 150
AETVRVIYDP QEVSFEDLIR TFFEAHDPTQ GFRQGNDVGT QYRSVIYAQT
160 170 180 190 200
DDEVQKAREI AESFSHSLAD AGYGGITTDI SLLSDTPTKT MYLAEDEHQQ
210 220
YLDKNPNGYC PVHSTGVACR
Length:220
Mass (Da):24,202
Last modified:July 7, 2009 - v1
Checksum:i73176FC288ED16C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001620 Genomic DNA Translation: ACR16905.1
RefSeqiWP_012730793.1, NC_012704.1

Genome annotation databases

EnsemblBacteriaiACR16905; ACR16905; ckrop_0108
KEGGickp:ckrop_0108

Similar proteinsi

Entry informationi

Entry nameiMSRA_CORK4
AccessioniPrimary (citable) accession number: C4LG69
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 7, 2009
Last modified: May 23, 2018
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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