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Protein

Cobalt-precorrin-5B C(1)-methyltransferase

Gene

cbiD

Organism
Tolumonas auensis (strain DSM 9187 / TA4)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.UniRule annotation

Catalytic activityi

Cobalt-precorrin-5B + S-adenosyl-L-methionine = cobalt-precorrin-6A + S-adenosyl-L-homocysteine.UniRule annotation

Pathwayi: adenosylcobalamin biosynthesis

This protein is involved in step 6 of the subpathway that synthesizes cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route).UniRule annotation
Proteins known to be involved in the 10 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. no protein annotated in this organism
  6. Cobalt-precorrin-5B C(1)-methyltransferase (cbiD)
  7. no protein annotated in this organism
  8. no protein annotated in this organism
  9. no protein annotated in this organism
  10. Cobyrinate a,c-diamide synthase (cbiA)
This subpathway is part of the pathway adenosylcobalamin biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route), the pathway adenosylcobalamin biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processCobalamin biosynthesis
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00148; UER00227

Names & Taxonomyi

Protein namesi
Recommended name:
Cobalt-precorrin-5B C(1)-methyltransferaseUniRule annotation (EC:2.1.1.195UniRule annotation)
Alternative name(s):
Cobalt-precorrin-6A synthaseUniRule annotation
Gene namesi
Name:cbiDUniRule annotation
Ordered Locus Names:Tola_1678
OrganismiTolumonas auensis (strain DSM 9187 / TA4)
Taxonomic identifieri595494 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeTolumonas
Proteomesi
  • UP000009073 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002129461 – 378Cobalt-precorrin-5B C(1)-methyltransferaseAdd BLAST378

Interactioni

Protein-protein interaction databases

STRINGi595494.Tola_1678

Structurei

3D structure databases

SMRiC4LFC1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CbiD family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EE8 Bacteria
COG1903 LUCA
HOGENOMiHOG000009126
KOiK02188
OMAiGGIFHTH
OrthoDBiPOG091H02QJ

Family and domain databases

Gene3Di3.30.2110.10, 1 hit
HAMAPiMF_00787 CbiD, 1 hit
InterProiView protein in InterPro
IPR002748 CbiD
IPR036074 CbiD_sf
PANTHERiPTHR35863 PTHR35863, 1 hit
PfamiView protein in Pfam
PF01888 CbiD, 1 hit
PIRSFiPIRSF026782 CbiD, 1 hit
SUPFAMiSSF111342 SSF111342, 1 hit
TIGRFAMsiTIGR00312 cbiD, 1 hit

Sequencei

Sequence statusi: Complete.

C4LFC1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIALADDKV WHKGKSYRKG YTTGSCATAA AKVATLMILR QQVIHQVSIV
60 70 80 90 100
TPSGVTLQLN VEEPLIHGLQ ASAAIRKDGG DDVDATHGML IYAQVVLRND
110 120 130 140 150
ATITISGGTG VGKVTRKGIG LPVGNAAINK TPLQTIEAAV REVLGPERGA
160 170 180 190 200
DITIFAPEGE ERAQRTYNGR LGIEGGISII GTTGIVTPMS EESWKRSLAL
210 220 230 240 250
ELEQKRAQGM EKIILVPGNH GERFVREQMQ LDSELVVTMS NFVGYMLQEA
260 270 280 290 300
ERLAFRHVVL IGHLGKLIKV AAGIFHTHSH IADGRMETLI THLALLGAPN
310 320 330 340 350
SLLQAIYACN TTEAAMELIE AQGYQEVYNT IATRICERIN QMLRYSPQPF
360 370
QCDAILFSLD NQPLGSNRPI TDIVEALR
Length:378
Mass (Da):41,095
Last modified:July 7, 2009 - v1
Checksum:i55DD4ED0517C5309
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001616 Genomic DNA Translation: ACQ93288.1

Genome annotation databases

EnsemblBacteriaiACQ93288; ACQ93288; Tola_1678
KEGGitau:Tola_1678

Similar proteinsi

Entry informationi

Entry nameiCBID_TOLAT
AccessioniPrimary (citable) accession number: C4LFC1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 7, 2009
Last modified: March 28, 2018
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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