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Protein

Cobalt-precorrin-5B C(1)-methyltransferase

Gene

cbiD

Organism
Tolumonas auensis (strain DSM 9187 / TA4)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.UniRule annotation

Catalytic activityi

Cobalt-precorrin-5B + S-adenosyl-L-methionine = cobalt-precorrin-6A + S-adenosyl-L-homocysteine.UniRule annotation

Pathwayi: adenosylcobalamin biosynthesis

This protein is involved in step 6 of the subpathway that synthesizes cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route).UniRule annotation
Proteins known to be involved in the 10 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. no protein annotated in this organism
  6. Cobalt-precorrin-5B C(1)-methyltransferase (cbiD)
  7. no protein annotated in this organism
  8. no protein annotated in this organism
  9. no protein annotated in this organism
  10. no protein annotated in this organism
This subpathway is part of the pathway adenosylcobalamin biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route), the pathway adenosylcobalamin biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Cobalamin biosynthesis

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciTAUE595494:GHEF-1734-MONOMER.
UniPathwayiUPA00148; UER00227.

Names & Taxonomyi

Protein namesi
Recommended name:
Cobalt-precorrin-5B C(1)-methyltransferaseUniRule annotation (EC:2.1.1.195UniRule annotation)
Alternative name(s):
Cobalt-precorrin-6A synthaseUniRule annotation
Gene namesi
Name:cbiDUniRule annotation
Ordered Locus Names:Tola_1678
OrganismiTolumonas auensis (strain DSM 9187 / TA4)
Taxonomic identifieri595494 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeTolumonas
Proteomesi
  • UP000009073 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 378378Cobalt-precorrin-5B C(1)-methyltransferasePRO_1000212946Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi595494.Tola_1678.

Family & Domainsi

Sequence similaritiesi

Belongs to the CbiD family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EE8. Bacteria.
COG1903. LUCA.
HOGENOMiHOG000009126.
KOiK02188.
OMAiMMVHSKS.
OrthoDBiEOG6WX4M7.

Family and domain databases

HAMAPiMF_00787. CbiD.
InterProiIPR002748. CbiD.
[Graphical view]
PfamiPF01888. CbiD. 1 hit.
[Graphical view]
PIRSFiPIRSF026782. CbiD. 1 hit.
SUPFAMiSSF111342. SSF111342. 1 hit.
TIGRFAMsiTIGR00312. cbiD. 1 hit.

Sequencei

Sequence statusi: Complete.

C4LFC1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIALADDKV WHKGKSYRKG YTTGSCATAA AKVATLMILR QQVIHQVSIV
60 70 80 90 100
TPSGVTLQLN VEEPLIHGLQ ASAAIRKDGG DDVDATHGML IYAQVVLRND
110 120 130 140 150
ATITISGGTG VGKVTRKGIG LPVGNAAINK TPLQTIEAAV REVLGPERGA
160 170 180 190 200
DITIFAPEGE ERAQRTYNGR LGIEGGISII GTTGIVTPMS EESWKRSLAL
210 220 230 240 250
ELEQKRAQGM EKIILVPGNH GERFVREQMQ LDSELVVTMS NFVGYMLQEA
260 270 280 290 300
ERLAFRHVVL IGHLGKLIKV AAGIFHTHSH IADGRMETLI THLALLGAPN
310 320 330 340 350
SLLQAIYACN TTEAAMELIE AQGYQEVYNT IATRICERIN QMLRYSPQPF
360 370
QCDAILFSLD NQPLGSNRPI TDIVEALR
Length:378
Mass (Da):41,095
Last modified:July 7, 2009 - v1
Checksum:i55DD4ED0517C5309
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001616 Genomic DNA. Translation: ACQ93288.1.
RefSeqiWP_015878759.1. NC_012691.1.

Genome annotation databases

EnsemblBacteriaiACQ93288; ACQ93288; Tola_1678.
KEGGitau:Tola_1678.
PATRICi23979979. VBITolAue42623_1661.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001616 Genomic DNA. Translation: ACQ93288.1.
RefSeqiWP_015878759.1. NC_012691.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi595494.Tola_1678.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACQ93288; ACQ93288; Tola_1678.
KEGGitau:Tola_1678.
PATRICi23979979. VBITolAue42623_1661.

Phylogenomic databases

eggNOGiENOG4105EE8. Bacteria.
COG1903. LUCA.
HOGENOMiHOG000009126.
KOiK02188.
OMAiMMVHSKS.
OrthoDBiEOG6WX4M7.

Enzyme and pathway databases

UniPathwayiUPA00148; UER00227.
BioCyciTAUE595494:GHEF-1734-MONOMER.

Family and domain databases

HAMAPiMF_00787. CbiD.
InterProiIPR002748. CbiD.
[Graphical view]
PfamiPF01888. CbiD. 1 hit.
[Graphical view]
PIRSFiPIRSF026782. CbiD. 1 hit.
SUPFAMiSSF111342. SSF111342. 1 hit.
TIGRFAMsiTIGR00312. cbiD. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 9187 / TA4.

Entry informationi

Entry nameiCBID_TOLAT
AccessioniPrimary (citable) accession number: C4LFC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 7, 2009
Last modified: November 11, 2015
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.