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Protein

Beta-hexosaminidase

Gene

nagZ

Organism
Tolumonas auensis (strain DSM 9187 / TA4)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides.UniRule annotation

Catalytic activityi

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.UniRule annotation

Pathwayi: peptidoglycan recycling

This protein is involved in the pathway peptidoglycan recycling, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan recycling and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei62SubstrateUniRule annotation1
Binding sitei70SubstrateUniRule annotation1
Binding sitei131SubstrateUniRule annotation1
Sitei172Important for catalytic activityUniRule annotation1
Active sitei174Proton donor/acceptorUniRule annotation1
Active sitei246NucleophileUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00544.

Protein family/group databases

CAZyiGH3. Glycoside Hydrolase Family 3.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-hexosaminidaseUniRule annotation (EC:3.2.1.52UniRule annotation)
Alternative name(s):
Beta-N-acetylhexosaminidaseUniRule annotation
N-acetyl-beta-glucosaminidaseUniRule annotation
Gene namesi
Name:nagZUniRule annotation
Ordered Locus Names:Tola_1542
OrganismiTolumonas auensis (strain DSM 9187 / TA4)
Taxonomic identifieri595494 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeTolumonas
Proteomesi
  • UP000009073 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002054621 – 334Beta-hexosaminidaseAdd BLAST334

Interactioni

Protein-protein interaction databases

STRINGi595494.Tola_1542.

Structurei

3D structure databases

ProteinModelPortaliC4LEY6.
SMRiC4LEY6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni161 – 162Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QPA. Bacteria.
COG1472. LUCA.
HOGENOMiHOG000248526.
KOiK01207.
OMAiHKETPRD.
OrthoDBiPOG091H039J.

Family and domain databases

Gene3Di3.20.20.300. 1 hit.
HAMAPiMF_00364. NagZ. 1 hit.
InterProiView protein in InterPro
IPR022956. Beta_hexosaminidase_bac.
IPR019800. Glyco_hydro_3_AS.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
PfamiView protein in Pfam
PF00933. Glyco_hydro_3. 1 hit.
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiView protein in PROSITE
PS00775. GLYCOSYL_HYDROL_F3. 1 hit.

Sequencei

Sequence statusi: Complete.

C4LEY6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPLMLDVQG CELDAEEREI LRHPTVGGVI LFGRNYHDRS QLSALVKTIR
60 70 80 90 100
QAANKPLLIA VDHEGGRVQR FRNGFSRIPP MGILHKARNQ ATDLATECGW
110 120 130 140 150
LMAAELLAHD IDLSFAPVLD LERGSNVIGD RSFSSDPEQV IQLASAFIDG
160 170 180 190 200
MHQAGMKATG KHFPGHGSVR ADSHLESPRD NRSWEEIEAT DLVPFRELIP
210 220 230 240 250
AGKLDAIMPA HVIYTELDDQ PAGFSRFWLQ EVLRGKYGFN GIIFSDDLTM
260 270 280 290 300
EGAAVAGGYP ERAQAALNAG CDMLLACNNR AGAVAILDGL QNPPASRAES
310 320 330
LLSTNNGDWS RLTSTSRWKN TQNRVQIFTE EFVN
Length:334
Mass (Da):36,672
Last modified:July 7, 2009 - v1
Checksum:i5C9336D8B5FF358F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001616 Genomic DNA. Translation: ACQ93153.1.
RefSeqiWP_015878625.1. NC_012691.1.

Genome annotation databases

EnsemblBacteriaiACQ93153; ACQ93153; Tola_1542.
KEGGitau:Tola_1542.

Similar proteinsi

Entry informationi

Entry nameiNAGZ_TOLAT
AccessioniPrimary (citable) accession number: C4LEY6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 7, 2009
Last modified: September 27, 2017
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families