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C4LDU8

- DAPF_TOLAT

UniProt

C4LDU8 - DAPF_TOLAT

Protein

Diaminopimelate epimerase

Gene

dapF

Organism
Tolumonas auensis (strain DSM 9187 / TA4)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 33 (01 Oct 2014)
      Sequence version 1 (07 Jul 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.UniRule annotation

    Catalytic activityi

    LL-2,6-diaminoheptanedioate = meso-diaminoheptanedioate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei13 – 131SubstrateUniRule annotation
    Binding sitei46 – 461SubstrateUniRule annotation
    Binding sitei66 – 661SubstrateUniRule annotation
    Active sitei75 – 751Proton donor/acceptorUniRule annotation
    Binding sitei159 – 1591SubstrateUniRule annotation
    Sitei161 – 1611Important for catalytic activityUniRule annotation
    Binding sitei192 – 1921SubstrateUniRule annotation
    Sitei210 – 2101Important for catalytic activityUniRule annotation
    Active sitei219 – 2191Proton donor/acceptorUniRule annotation

    GO - Molecular functioni

    1. diaminopimelate epimerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Amino-acid biosynthesis, Lysine biosynthesis

    Enzyme and pathway databases

    BioCyciTAUE595494:GHEF-3242-MONOMER.
    UniPathwayiUPA00034; UER00025.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Diaminopimelate epimeraseUniRule annotation (EC:5.1.1.7UniRule annotation)
    Short name:
    DAP epimeraseUniRule annotation
    Gene namesi
    Name:dapFUniRule annotation
    Ordered Locus Names:Tola_3121
    OrganismiTolumonas auensis (strain DSM 9187 / TA4)
    Taxonomic identifieri595494 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeTolumonas
    ProteomesiUP000009073: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 276276Diaminopimelate epimerasePRO_1000204069Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi75 ↔ 219

    Keywords - PTMi

    Disulfide bond

    Interactioni

    Protein-protein interaction databases

    STRINGi595494.Tola_3121.

    Structurei

    3D structure databases

    ProteinModelPortaliC4LDU8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni10 – 112Substrate bindingUniRule annotation
    Regioni75 – 773Substrate bindingUniRule annotation
    Regioni210 – 2112Substrate bindingUniRule annotation
    Regioni220 – 2212Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the diaminopimelate epimerase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0253.
    HOGENOMiHOG000220466.
    KOiK01778.
    OMAiLIVEPPY.
    OrthoDBiEOG6ND0M5.

    Family and domain databases

    HAMAPiMF_00197. DAP_epimerase.
    InterProiIPR018510. DAP_epimerase_AS.
    IPR001653. DAP_epimerase_DapF.
    [Graphical view]
    PANTHERiPTHR31689. PTHR31689. 1 hit.
    PfamiPF01678. DAP_epimerase. 2 hits.
    [Graphical view]
    TIGRFAMsiTIGR00652. DapF. 1 hit.
    PROSITEiPS01326. DAP_EPIMERASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C4LDU8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLIQFSKMHG LGNDFVVVDG VTQKVFFNAE TLKRLGDRHF GIGFDQLLLV    50
    EPPYDPDLDF HYRIFNADGS EVQQCGNGAR CFARFVRLKG LTNKDRIAVS 100
    TVSGRIVLQL EDNDQVTVNM GVPEFEPAKI PFRALKAEKL YLLRVAEQTV 150
    MCGVVSMGNP HCVIEVPSVK DAPVETLGPK LESFDRFPER INVGFMEVVS 200
    ASEINLRVYE RGAGETLACG TGACAAVVVG IQQEKLKGRV KVNLPGGSLY 250
    ISWNGPGSPV YMTGPAEHVF DGQIEL 276
    Length:276
    Mass (Da):30,277
    Last modified:July 7, 2009 - v1
    Checksum:iEAE53F6F26F464A2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001616 Genomic DNA. Translation: ACQ94709.1.
    RefSeqiWP_015880158.1. NC_012691.1.
    YP_002894295.1. NC_012691.1.

    Genome annotation databases

    EnsemblBacteriaiACQ94709; ACQ94709; Tola_3121.
    GeneIDi7885319.
    KEGGitau:Tola_3121.
    PATRICi23982999. VBITolAue42623_3108.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001616 Genomic DNA. Translation: ACQ94709.1 .
    RefSeqi WP_015880158.1. NC_012691.1.
    YP_002894295.1. NC_012691.1.

    3D structure databases

    ProteinModelPortali C4LDU8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 595494.Tola_3121.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACQ94709 ; ACQ94709 ; Tola_3121 .
    GeneIDi 7885319.
    KEGGi tau:Tola_3121.
    PATRICi 23982999. VBITolAue42623_3108.

    Phylogenomic databases

    eggNOGi COG0253.
    HOGENOMi HOG000220466.
    KOi K01778.
    OMAi LIVEPPY.
    OrthoDBi EOG6ND0M5.

    Enzyme and pathway databases

    UniPathwayi UPA00034 ; UER00025 .
    BioCyci TAUE595494:GHEF-3242-MONOMER.

    Family and domain databases

    HAMAPi MF_00197. DAP_epimerase.
    InterProi IPR018510. DAP_epimerase_AS.
    IPR001653. DAP_epimerase_DapF.
    [Graphical view ]
    PANTHERi PTHR31689. PTHR31689. 1 hit.
    Pfami PF01678. DAP_epimerase. 2 hits.
    [Graphical view ]
    TIGRFAMsi TIGR00652. DapF. 1 hit.
    PROSITEi PS01326. DAP_EPIMERASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 9187 / TA4.

    Entry informationi

    Entry nameiDAPF_TOLAT
    AccessioniPrimary (citable) accession number: C4LDU8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: July 7, 2009
    Last modified: October 1, 2014
    This is version 33 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3