Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

C4LDE6

- GCH1_TOLAT

UniProt

C4LDE6 - GCH1_TOLAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

GTP cyclohydrolase 1

Gene

folE

Organism
Tolumonas auensis (strain DSM 9187 / TA4)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi109 – 1091ZincUniRule annotation
Metal bindingi112 – 1121ZincUniRule annotation
Metal bindingi180 – 1801ZincUniRule annotation

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
  2. one-carbon metabolic process Source: UniProtKB-HAMAP
  3. tetrahydrofolate biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

GTP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciTAUE595494:GHEF-1159-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase 1UniRule annotation (EC:3.5.4.16UniRule annotation)
Alternative name(s):
GTP cyclohydrolase IUniRule annotation
Short name:
GTP-CH-IUniRule annotation
Gene namesi
Name:folEUniRule annotation
Ordered Locus Names:Tola_1116
OrganismiTolumonas auensis (strain DSM 9187 / TA4)
Taxonomic identifieri595494 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeTolumonas
ProteomesiUP000009073: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 216216GTP cyclohydrolase 1PRO_1000204301Add
BLAST

Interactioni

Subunit structurei

Homopolymer.UniRule annotation

Protein-protein interaction databases

STRINGi595494.Tola_1116.

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase I family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0302.
HOGENOMiHOG000221222.
KOiK01495.
OMAiVQFFSSR.
OrthoDBiEOG6XHC8G.

Family and domain databases

HAMAPiMF_00223. FolE.
InterProiIPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view]
PANTHERiPTHR11109. PTHR11109. 1 hit.
PfamiPF01227. GTP_cyclohydroI. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00063. folE. 1 hit.
PROSITEiPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C4LDE6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTHLSKEAVI VRSALEAKGL ETPMQHSSLS AQEKKQQIEQ HMTSIMTLLG
60 70 80 90 100
LDLADDSLAE TPHRIAKMYV DEIFSGLDYG SFPKITLIEN KMGTDEMIKV
110 120 130 140 150
QDIGLTSTCE HHFVTIDGKA TVAYIPKDKI IGLSKINRIV NFFAKRPQVQ
160 170 180 190 200
ERLTQQILVA LQVLLGTDNV AITVTATHYC VKSRGVMDAS SQTTTTALGG
210
VFKSSAATRH EFLSRA
Length:216
Mass (Da):23,762
Last modified:July 7, 2009 - v1
Checksum:iB15025B4C87C418B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001616 Genomic DNA. Translation: ACQ92742.1.
RefSeqiYP_002892328.1. NC_012691.1.

Genome annotation databases

EnsemblBacteriaiACQ92742; ACQ92742; Tola_1116.
GeneIDi7886168.
KEGGitau:Tola_1116.
PATRICi23978853. VBITolAue42623_1111.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001616 Genomic DNA. Translation: ACQ92742.1 .
RefSeqi YP_002892328.1. NC_012691.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 595494.Tola_1116.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACQ92742 ; ACQ92742 ; Tola_1116 .
GeneIDi 7886168.
KEGGi tau:Tola_1116.
PATRICi 23978853. VBITolAue42623_1111.

Phylogenomic databases

eggNOGi COG0302.
HOGENOMi HOG000221222.
KOi K01495.
OMAi VQFFSSR.
OrthoDBi EOG6XHC8G.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci TAUE595494:GHEF-1159-MONOMER.

Family and domain databases

HAMAPi MF_00223. FolE.
InterProi IPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view ]
PANTHERi PTHR11109. PTHR11109. 1 hit.
Pfami PF01227. GTP_cyclohydroI. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00063. folE. 1 hit.
PROSITEi PS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 9187 / TA4.

Entry informationi

Entry nameiGCH1_TOLAT
AccessioniPrimary (citable) accession number: C4LDE6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 7, 2009
Last modified: October 1, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3