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Protein

DNA mismatch repair protein MutH

Gene

mutH

Organism
Tolumonas auensis (strain DSM 9187 / TA4)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

EndonucleaseUniRule annotationSAAS annotation, Hydrolase, Nuclease

Keywords - Biological processi

DNA damage, DNA repairUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciTAUE595494:GHEF-3080-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA mismatch repair protein MutHUniRule annotationSAAS annotation
Alternative name(s):
Methyl-directed mismatch repair proteinUniRule annotation
Gene namesi
Name:mutHUniRule annotation
Ordered Locus Names:Tola_2964Imported
OrganismiTolumonas auensis (strain DSM 9187 / TA4)Imported
Taxonomic identifieri595494 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeTolumonas
ProteomesiUP000009073 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi595494.Tola_2964.

Family & Domainsi

Sequence similaritiesi

Belongs to the MutH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG3066.
HOGENOMiHOG000271839.
KOiK03573.
OMAiLRPKGAN.
OrthoDBiEOG6CGCC0.

Family and domain databases

Gene3Di3.40.600.10. 1 hit.
HAMAPiMF_00759. MutH.
InterProiIPR004230. DNA_mismatch_repair_MutH.
IPR011337. DNA_rep_MutH/RE_typeII.
IPR011335. Restrct_endonuc-II-like.
[Graphical view]
PfamiPF02976. MutH. 1 hit.
[Graphical view]
SMARTiSM00927. MutH. 1 hit.
[Graphical view]
SUPFAMiSSF52980. SSF52980. 1 hit.
TIGRFAMsiTIGR02248. mutH_TIGR. 1 hit.

Sequencei

Sequence statusi: Complete.

C4LD22-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYQNIDELVH AANQLAGLTL AELAERCGIM IPSSLRREKG WIGQLLEFAL
60 70 80 90 100
GASAGSKPQQ DFPELGVELK TLPIANNGIP LESTFVCTAP LLHQQKITWE
110 120 130 140 150
TSSVHHKLSA VLWIPVFGDR QQDIASRMIG NPWLWHPTAE QEKIIRQDWE
160 170 180 190 200
EIMELIALGK VESISARHGE ALQLRPKAAN GQSLTPAIGG EGTIIQTRPR
210
GFYLRSSFTR ELLHMQFYL
Length:219
Mass (Da):24,486
Last modified:July 7, 2009 - v1
Checksum:i88538495914D97FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001616 Genomic DNA. Translation: ACQ94553.1.
RefSeqiWP_015880002.1. NC_012691.1.
YP_002894139.1. NC_012691.1.

Genome annotation databases

EnsemblBacteriaiACQ94553; ACQ94553; Tola_2964.
KEGGitau:Tola_2964.
PATRICi23982681. VBITolAue42623_2954.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001616 Genomic DNA. Translation: ACQ94553.1.
RefSeqiWP_015880002.1. NC_012691.1.
YP_002894139.1. NC_012691.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi595494.Tola_2964.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACQ94553; ACQ94553; Tola_2964.
KEGGitau:Tola_2964.
PATRICi23982681. VBITolAue42623_2954.

Phylogenomic databases

eggNOGiCOG3066.
HOGENOMiHOG000271839.
KOiK03573.
OMAiLRPKGAN.
OrthoDBiEOG6CGCC0.

Enzyme and pathway databases

BioCyciTAUE595494:GHEF-3080-MONOMER.

Family and domain databases

Gene3Di3.40.600.10. 1 hit.
HAMAPiMF_00759. MutH.
InterProiIPR004230. DNA_mismatch_repair_MutH.
IPR011337. DNA_rep_MutH/RE_typeII.
IPR011335. Restrct_endonuc-II-like.
[Graphical view]
PfamiPF02976. MutH. 1 hit.
[Graphical view]
SMARTiSM00927. MutH. 1 hit.
[Graphical view]
SUPFAMiSSF52980. SSF52980. 1 hit.
TIGRFAMsiTIGR02248. mutH_TIGR. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 9187 / TA4Imported.

Entry informationi

Entry nameiC4LD22_TOLAT
AccessioniPrimary (citable) accession number: C4LD22
Entry historyi
Integrated into UniProtKB/TrEMBL: July 7, 2009
Last sequence update: July 7, 2009
Last modified: April 29, 2015
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.